BindingDB logo
myBDB logout

233 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26514744 46 Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease.EBI Ataturk University
26510670 9 Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents.EBI Lehigh University
26454504 28 Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors.EBI China Pharmaceutical University
26386602 97 Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.EBI Virginia Tech
26244990 78 Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease.EBI Bezmialem Vakif University
26337018 44 Multifunctional novel Diallyl disulfide (DADS) derivatives with▀-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.EBI University of Delhi
26242241 30 Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Jagiellonian University Medical College
26278660 90 Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.EBI University of Jena
26212777 22 Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening.EBI Nanjing University of Chinese Medicine
25678013 63 Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer's disease.EBI Sichuan University
25282654 56 Design, synthesis and evaluation of novel tacrine-(▀-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
25980913 9 Allobetulin derived seco-oleananedicarboxylates act as inhibitors of acetylcholinesterase.EBI Martin-Luther-Universit£t Halle-Wittenberg
26107513 172 Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.EBI Universit£ degli Studi di Bari"Aldo Moro"
26030662 3 In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier.EBI Charles University
25778991 116 Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.EBI Sichuan University
25969170 38 Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain.EBI Tehran University of Medicinal Sciences
25812965 80 Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.EBI China Pharmaceutical University
25768702 86 Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties.EBI Universiti Sains Malaysia
25621991 62 Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and▀-amyloid aggregation inhibitors with neuroprotective properties.EBI Jagiellonian University Medical College
25681712 16 Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors.EBI Islamic Azad University
25656088 32 Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.EBI China Pharmaceutical University
25636055 13 Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives.EBI Tehran University of Medical Sciences
25868744 51 Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with▀-amyloid anti-aggregation properties and beneficial effects on memory in vivo.EBI Jagiellonian University
25724825 27 Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Wenzhou Medical University
25707322 47 Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.EBI Jagiellonian University Medical College
25624107 74 Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease.EBI University of Delhi
25597007 14 Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.EBI Universit£ di Pisa
25597004 18 Iminosugars as a new class of cholinesterase inhibitors.EBI Universit£ de Strasbourg/CNRS (UMR 7509)
25047936 183 Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode.EBI Universit£t Regensburg
25036795 45 Indolinone-based acetylcholinesterase inhibitors: synthesis, biological activity and molecular modeling.EBI Yazd University
25462245 27 New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: efficient synthesis, biological assessment and docking simulation study.EBI Tehran University of Medical Sciences
25257911 33 Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis.EBI Quaid-i-Azam University
24941128 41 Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives.EBI Tehran University of Medical Sciences
24853320 62 Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases.EBI Martin-Luther-Universit£t Halle-Wittenberg
24813882 41 Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.EBI Okayama University
24794747 36 Novel aromatic-polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.EBI Henan University
950651 6 Synthesis and properties of 2-S-(N,N-dialkylamino)ethyl)thio-1,3,2-dioxaphosphorinane 2-oxide and of the corresponding quaternary derivatives as potential nontoxic antiglaucoma agents.EBI TBA
592327 104 Potent reversible anticholinesterase agents. Bis- and mono-N-substituted benzoquinolinium halides.EBI TBA
556774 58 Inhibition of acetylcholinesterase by thiamine. A structure-function study.EBI TBA
24819955 36 Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.EBI University of W£rzburg
24726809 72 Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.EBI China Pharmaceutical University
24594354 46 Synthesis and discovery of highly functionalized mono- and bis-spiro-pyrrolidines as potent cholinesterase enzyme inhibitors.EBI Universiti Sains Malaysia
24681981 53 Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines.EBI Quaid-i-Azam University
24675179 26 Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases.EBI Quaid-I-Azam University
24657052 42 Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.EBI Universit£ de Franche Comt£
24594525 25 Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents.EBI Southeast University
24589487 7 Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Sichuan University
24556381 4 Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase.EBI Universidad de Buenos Aires
24530494 42 Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.EBI Laboratorio de Qu�mica M�dica (IQOG, CSIC)
24502897 9 Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzheimer's disease.EBI Universidad Complutense de Madrid (UCM)
24389509 17 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.EBI Universitat de Barcelona
24461494 28 Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.EBI Sun Yat-sen University
24547899 4 Isolation and synthesis of pulmonarins A and B, acetylcholinesterase inhibitors from the colonial ascidian Synoicum pulmonaria.EBI University of Troms£
24369842 62 Cholinesterase inhibitory activity versus aromatic core multiplicity: a facile green synthesis and molecular docking study of novel piperidone embedded thiazolopyrimidines.EBI Universiti Sains Malaysia
24220172 25 Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.EBI Sun Yat-sen University
24148835 41 Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.EBI Henan University
24128814 38 Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.EBI Sun Yat-sen University
24211638 28 Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors.EBI Kerman University of Medical Sciences
24160297 37 Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.EBI Sun Yat-sen University
24148993 4 Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection.EBI Punjabi University
24095756 48 Multifunctional tacrine-flavonoid hybrids with cholinergic,▀-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
23988412 39 Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.EBI Tehran University of Medical Sciences
23988409 32 Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Tehran University of Medical Sciences
23932451 34 Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and A▀ aggregation and antioxidant activity.EBI Sun Yat-sen University
23871902 42 An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study.EBI Universiti Sains Malaysia
23891231 42 Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.EBI Ege University
23810675 42 Synthesis, evaluation and molecular dynamics study of some new 4-aminopyridine semicarbazones as an antiamnesic and cognition enhancing agents.EBI Banaras Hindu University
23768661 6 Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.EBI Universidade T£cnica de Lisboa
23799643 5 Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.EBI Sun Yat-sen University
23721952 34 An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles.EBI Madurai Kamaraj University
23685572 55 Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.EBI China Pharmaceutical University
23644208 40 Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.EBI University of Zanjan
23535563 64 Investigation of the role of linker moieties in bifunctional tacrine hybrids.EBI University of Michigan
23511019 60 Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.EBI China Pharmaceutical University
23602518 50 Microwave assisted synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new pyridopyrimidine derivatives.EBI Universiti Sains Malaysia
23562059 6 Design, synthesis and evaluation of some new 4-aminopyridine derivatives in learning and memory.EBI Banaras Hindu University
23639542 32 NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity.EBI China Pharmaceutical University
23583510 17 Novel racemic tetrahydrocurcuminoid dihydropyrimidinone analogues as potent acetylcholinesterase inhibitors.EBI Ramkhamhaeng University
23541836 24 Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents.EBI China Pharmaceutical University
23501115 62 Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Sun Yat-sen University
23434223 21 A one-pot domino synthesis and discovery of highly functionalized dihydrobenzo[b]thiophenes as AChE inhibitors.EBI Madurai Kamaraj University
23462716 49 Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors.EBI University of Pardubice
23454517 56 A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.EBI Sun Yat-sen University
23376249 46 Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors.EBI University of Life Sciences
23330848 8 Acetylcholinesterase immobilized capillary reactors-tandem mass spectrometry: an on-flow tool for ligand screening.EBI Universidade Federal de S£o Carlos
20926161 21 Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.EBI Jagiellonian University Medical College
20158205 34 Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors.EBI China Pharmaceutical University
6471073 1 Nonquaternary cholinesterase reactivators. 2. Alpha-heteroaromatic aldoximes and thiohydroximates as reactivators of ethyl methylphosphonyl-acetylcholinesterase in vitro.EBI TBA
23140986 38 Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors.EBI University College of Science
22795665 24 Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.EBI Universit£ de Sfax
22624880 16 Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.EBI Universit£t Regensburg
22512543 72 Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.EBI China Pharmaceutical University
23062825 37 Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.EBI Abo Akademi University
23000296 40 Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity,ß-amyloid aggregation and Ca²¿ overload.EBI Huazhong University of Science and Technology
23108363 6 Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase.EBI Universit£ degli Studi di Bari Aldo Moro
22981331 14 Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.EBI Sun Yat-Sen University
22944335 43 O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-ß aggregation.EBI Sun Yat-sen University
22633691 42 Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.EBI Sun Yat-sen University
22420827 14 Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases.EBI Huazhong University of Science and Technology
21715067 15 Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives.EBI University of Lisbon
22503231 66 Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.EBI Laboratorio de Radicales Libres y Qu�mica Computacional (IQOG, CSIC)
22472046 40 Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.EBI Sun Yat-sen University
22472693 17 Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques.EBI China Pharmaceutical University
22425563 16 Prospective acetylcholinesterase inhibitory activity of indole and its analogs.EBI Naresuan University
22444876 34 Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.EBI Sun Yat-sen University
21510637 9 Azaphilones and p-terphenyls from the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2) isolated from the South China Sea.EBI Sun Yat-sen University
20850311 9 Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities.EBI Zhejiang University
20828184 21 Characterization of Acetylcholinesterase Inhibitory Constituents from Annona glabra Assisted by HPLC Microfractionation.EBI National Taiwan University
20580236 60 Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors.EBI University of Innsbruck and Center for Molecular Biosciences Innsbruck-CMBI
20575555 45 Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.EBI Universidad Autonoma de Madrid
20350808 36 Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: novel heterocyclic templates for butyrylcholinesterase inhibitors.EBI Friedrich-Schiller-Universit£t Jena
20067290 24 Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.EBI Trinity College
18640842 45 New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.EBI CSIC)
16989531 10 Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.EBI Leopold Franzens-Universit£t
18479118 113 Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.EBI Universit£ di Siena
17574306 29 Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.EBI Sun Yat-sen University
18406135 22 Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.EBI Friedrich-Schiller-Universit£t Jena
17451950 36 Derivatives of oxoisoaporphine alkaloids: a novel class of selective acetylcholinesterase inhibitors.EBI Sun Yat-Sen University
17944454 34 First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.EBI University of Bonn
17888667 33 Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate.EBI University of Mysore
14998318 112 Selective optimization of side activities: another way for drug discovery.EBI Prestwick Chemical Inc.
15139762 133 Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.EBI University of Hamburg
11495583 62 Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.EBI Universit£ Louis Pasteur
8978837 60 Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.EBI University of North Carolina
2913310 68 Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.EBI SRI International
3193422 8 Synthesis and anticholinesterase activity of (-)-N1-norphysostigmine, (-)-eseramine, and other N(1)-substituted analogues of (-)-physostigmine.EBI NIDDK
22341944 29 Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.EBI School of Chemistry& Chemical Engineering of Guangxi Normal University
22142546 16 AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3¿]-2,3-dihydro-1H-inden-1¿-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.EBI Universiti Sains Malaysia
22075233 16 New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds.EBI The University of Adelaide
22041172 41 Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.EBI Guangzhou Institute of Biomedicine and Health
22023459 42 Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.EBI Universitat Aut£noma de Barcelona
21975066 59 Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization.EBI The Scripps Research Institute
22019228 52 Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-ß aggregation.EBI Sun Yat-sen University
22000936 33 Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.EBI University of Lisbon
21939219 16 Benzofurans from Styrax agrestis as acetylcholinesterase inhibitors: structure-activity relationships and molecular modeling studies.EBI Guangzhou University of Chinese Medicine
21923104 12 HLE-inhibitory alkaloids with a polyketide skeleton from the marine-derived fungus Coniothyrium cereale.EBI University of Bonn
21871694 28 Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-inducedß-amyloid aggregation inhibitors.EBI Guangxi Normal University
21641207 10 New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights.EBI University Putra Malaysia
21621414 11 Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase.EBI Universiti Sains Malaysia
21546135 10 Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.EBI University of Santo Tomas
21435752 76 New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation.EBI CNRS
21497959 28 Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.EBI Sun Yat-sen University
21367493 32 Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation.EBI Sun Yat-sen University
21397508 36 Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.EBI Sun Yat-sen University
21411323 24 Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.EBI Universit£ de Sfax
21273074 10 Discovery of dual binding site acetylcholinesterase inhibitors identified by pharmacophore modeling and sequential virtual screening techniques.EBI National Institute of Pharmaceutical Education and Research (NIPER)
21232964 50 Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.EBI Queen's University Belfast
21111515 12 Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.EBI Université de Franche-Comté
21111617 1 Silanetriols as in vitro inhibitors for AChE.EBI Karl-Franzens-Universit£t Graz
21211982 30 Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.EBI Sun Yat-sen University
21163662 39 Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.EBI Laboratorio de Radicales Libres y Qu�mica Computacional (IQOG, CSIC)
20943395 10 4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity.EBI University of Malaya
20880702 35 Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase.EBI Sun Yat-sen University
20673725 22 Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives.EBI Tehran University of Medical Sciences
20656495 56 Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.EBI Laboratorio de Radicales Libres y Química Computacional (IQOG, CSIC)
20471843 60 Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.EBI Sun Yat-sen University
20472431 32 Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.EBI University of Waterloo
20452769 74 Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase.EBI Sun Yat-sen University
20361801 100 Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.EBI Friedrich-Schiller-Universitat Jena
20350807 7 Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.EBI Laboratorio de Radicales Libres y Química Computacional (IQOG, CSIC)
20347302 19 Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction.EBI Lehigh University
20079560 28 Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.EBI Sun Yat-sen University
19643609 14 Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues.EBI Alwar Pharmacy College
19446931 3 New potential AChE inhibitor candidates.EBI Universidade Bras£lia
20056426 38 Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.EBI Sun Yat-sen University
20149667 17 Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases.EBI Ege-University
20093035 9 Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.EBI Trinity College
20061157 45 4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields.EBI Institute
19493592 30 Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase.EBI University of Mysore
19243862 36 Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase.EBI Sun Yat-sen University
9287420 4 Structure and anti-acetylcholinesterase activity of 4 alpha-(hydroxymethyl)-4 alpha-demethylterritrem B.EBI National Taiwan University
19447614 1 Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum.EBI Hokkaido University
19053746 22 NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity.EBI Friedrich Schiller University Jena
18817366 43 Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.EBI Trinity College
18701305 29 Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues.EBI China Pharmaceutical University
18524585 20 Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Sun Yat-sen University
18343673 39 Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties.EBI Friedrich-Schiller-Universität Jena
17624631 9 Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Università di Bologna
12828454 8 New triterpenoid alkaloid cholinesterase inhibitors from Buxus hyrcana.EBI University of Karachi
11421762 6 Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.EBI Tribhuvan University
9461651 14 Litebamine N-homologues: preparation and anti-acetylcholinesterase activity.EBI National Taiwan University
18356045 3 N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum.EBI Universitat de Barcelona
17681794 43 Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.EBI Woosuk University
17181144 30 Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.EBI CSIC)
17085051 9 Preparation of secolycorines against acetylcholinesterase.EBI National Taiwan University
16942014 32 Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase.EBI Friedrich-Schiller-Universität Jena
16735118 23 Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.EBI University of Mysore
16366609 77 Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition.EBI University of Bonn
16274989 40 Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum.EBI University of Karachi
14611850 8 Cage amines as the stopper inhibitors of cholinesterases.EBI National Chung-Hsing University
12824041 14 Synthesis and structure-activity relationships of open D-Ring galanthamine analogues.EBI C.N.R.S.
12773040 41 Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.EBI Università degli Studi di Urbino Carlo Bo
10888326 12 Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors.EBI Seoul National University
10762042 8 Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts.EBI C.N.R.S.
9873371 1 Inhibition of electric eel acetylcholinesterase by porphin compounds.EBI Taejon National University of Technology
9871563 31 Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.EBI Istituto di Strutturistica Chimica G. Giacomello
6827532 2 In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide.EBI TBA
3783578 36 Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro.EBI TBA
2202827 53 Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.EBI NIDDK
27434226 140 Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease.BDB Wuhan University of Technology
27085663 30 Novel N-allyl/propargyl tetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels-Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors.BDB Universidad de Talcaa
27750058 46 Rational design and synthesis of dihydropyrimidine based dual binding site acetylcholinesterase inhibitors.BDB Hazara University
27289559 38 Design and synthesis of novel anti-Alzheimer's agents: Acridine-chromenone and quinoline-chromenone hybrids.BDB Tehran University of Medical Sciences
27231829 34 New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives.BDB Universidade de ╔vora
26833890 18 Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.BDB Yogi Vemana University
26943478 16 Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives.BDB Chulabhorn Research Institute
26851737 36 One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies.BDB University of Karachi
26451651 20 Pyridine sulfonamide as a small key organic molecule for the potential treatment of type-II diabetes mellitus and Alzheimer's disease: In vitro studies against yeast a-glucosidase, acetylcholinesterase and butyrylcholinesterase.BDB GC University
26440714 28 Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives.BDB Quaid-I-Azam University
26077890 33 Design, Synthesis, Biological Evaluation, and Docking Study of Acetylcholinesterase Inhibitors: New Acridone-1,2,4-oxadiazole-1,2,3-triazole Hybrids.BDB Tehran University of Medical Sciences
26010139 34 Synthesis and anticholinergic activity of 4-hydroxycoumarin derivatives containing substituted benzyl-1,2,3-triazole moiety.BDB Tehran University of Medical Sciences
25951978 38 Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives.BDB University of Karachi
25706320 86 Synthesis, antioxidant and anticholinesterase activities of novel coumarylthiazole derivatives.BDB Bezmialem Vakif University
25462625 58 Salicylanilide diethyl phosphates as cholinesterases inhibitors.BDB Charles University in Prague
22341898 7 Synthesis and inhibitory activity of ureidophosphonates, against acetylcholinesterase: pharmacological assay and molecular modeling.BDB Institute for Advanced Studies in Basic Sciences (IASBS)
21621811 10 Synthesis and biological activity of derivatives of tetrahydroacridine as acetylcholinesterase inhibitors.BDB Medical University of Lodz
19374444 45 Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.BDB CSIC
17902635 86 New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.BDB CNRS
17149883 62 Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.BDB Rheinische Friedrich-Wilhelms-Universitat Bonn
15563167 10 The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.BDB Weizmann Institute of Science