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49 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25461326 20 Conformationally-locked N-glycosides: exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease.EBI Universitat Rovira i Virgili
25250725 295 Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.EBI Leiden University
24803362 12 Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy.EBI Technical University Graz
24657053 8 Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.EBI University of Toyama
23880081 8 Rapid modifications of N-substitution in iminosugars: development of new▀-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease.EBI Genomics Research Center
23611766 8 Skeletal rearrangement of seven-membered iminosugars: synthesis of (-)-adenophorine, (-)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors.EBI Universit£ de Poitiers
23545138 4 (3R,4S,5R,6R,7S)-3,4,5,7-Tetrahydroxyconidine, an azetidine analogue of 6,7-diepicastanospermine and a conformationally constrained d-deoxyaltronojirimycin, from l-arabinose.EBI University of Oxford
19397268 21 Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.EBI Peking University
23106358 96 a-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based orala-glucosidase inhibitor for improving postprandial hyperglycemia.EBI University of Toyama
22646221 11 Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.EBI National Center for Advancing Translation Sciences
22762530 2 Conformationally-locked N-glycosides with selectiveß-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease.EBI Universitat Rovira i Virgili
22512696 61 Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease.EBI Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC)
22360565 20 Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease.EBI University of British Columbia
20557054 56 Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease.EBI Universitat de Barcelona
18595718 51 In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.EBI Hokuriku University
10843222 17 Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton.EBI University of Tokyo
10098675 6 Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors.EBI Technische Universit£t Berlin
9871687 6 A new strong inhibitor of beta-mannosidase.EBI S.E.S.N.A.B., Pole Sciences et Technologie, Universit� de La Rochelle.
20971647 12 Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes.EBI UMR CNRS 7201
21862336 9 Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes.EBI University of Reading
21546253 41 Docking and SAR studies of D- and L-isofagomine isomers as humanß-glucocerebrosidase inhibitors.EBI University of Toyama
21370884 80 New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening.EBI Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas)
21292481 4 Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease.EBI Aarhus University
20889348 9 Fluorescent-tagged sp2-iminosugars with potentß-glucosidase inhibitory activity.EBI Universidad de Sevilla
17187079 1 Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.EBI Harvard Medical School
20231099 9 Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors.EBI Universit£ d'Orl£ans& CNRS
19931460 6 Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.EBI Utrecht University
15165148 13 Glycosidase-inhibiting pyrrolidines and pyrrolizidines with a long side chain in Scilla peruviana.EBI Hokuriku University
11392550 5 Powerful probes for glycosidases: novel, fluorescently tagged glycosidase inhibitors.EBI Institut für Biochemie der Technischen Universität Graz
11327590 7 Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors.EBI Technische Universität Graz
23775891 83 New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease.BDB Nankai University
21751327 10 Synthesis, kinetic evaluation and cell-based analysis of C-alkylated isofagomines as chaperones of ╬▓-glucocerebrosidase.BDB University of British Columbia
18972510 6 Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.BDB Research Institute, Hospital for Sick Children
21079602 5 Ultrasensitive in situ visualization of active glucocerebrosidase molecules.BDB Leiden University
17827006 36 N(4)-Phenyl modifications of N(2)-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease.BDB NIH
17670938 23 Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.BDB NIH
17201413 5 Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention.BDB The Scripps Research Institute
16919960 27 Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease.BDB Hokuriku University