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59 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25897973 29 Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.EBI Takeda Pharmaceutical Co., Ltd.
23386702 10 Reversible inhibition of human carboxylesterases by acyl glucuronides.EBI Eisai Inc.
25349648 29 Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.EBI Merck Research Laboratories
24900877 107 Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.EBI Merck Research Laboratories
24618302 49 Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.EBI Merck Research Laboratories
24670009 65 Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents.EBI Amgen Inc.
23871442 88 Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.EBI Pfizer Inc.
23711919 62 Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.EBI Kitasato University
23665143 8 Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo.EBI Kumamoto University
23535327 44 Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.EBI Kitasato University
23419736 58 Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors.EBI Dongguk University-Seoul
23369538 88 Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.EBI Kitasato University
23317570 42 Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.EBI Merck Research Laboratories
23286284 50 Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").EBI St. Jude Children's Research Hospital
19062296 63 Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.EBI Kyoto University
23116186 68 Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).EBI AstraZeneca
23025824 6 Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloidß (Aß) oligomers-induced neuronal cell death by tricyclic pyrone molecules.EBI Kansas State University
19534556 57 Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.EBI St. Jude Children's Research Hospital
18630870 236 Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.EBI Institute for Chemical Biology
18247553 174 Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.EBI The Scripps Research Institute
18023188 86 Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).EBI University of California
18284184 4 Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors.EBI Universita di Milano
17279740 191 Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.EBI The Scripps Research Institute
15261286 18 Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas.EBI Korea Research Institute of Bioscience and Biotechnology
7241506 40 New analgesic drugs derived from phencyclidine.EBI TBA
22079027 8 Conformationally restricted analog and biotin-labeled probe based on beauveriolide III.EBI Tohoku University
21733699 121 Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.EBI St. Jude Children's Research Hospital
21413799 63 Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.EBI Hoffmann-La Roche Inc.
21105730 30 Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.EBI St. Jude Children's Research Hospital
20833038 98 Discovery of pyrrolopyridazines as novel DGAT1 inhibitors.EBI Amgen Inc.
19167888 20 Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression.EBI Dainippon Sumitomo Pharma Co., Ltd
18639454 55 Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.EBI The Scripps Research Institute
18620381 9 Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid.EBI Kyoto Pharmaceutical Industries
17399985 136 Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.EBI St. Jude Children's Research Hospital
17157006 21 Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon.EBI National Research Laboratory of Lipid Metabolism and Atherosclerosis
16919944 25 Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.EBI National Research Laboratory of Lipid Metabolism and Atherosclerosis
16302810 9 Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors.EBI Università di Milano
16107154 41 Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.EBI St. Jude Children's Research Hospital
15771430 129 Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.EBI The Scripps Research Institute
15713400 99 Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.EBI The Scripps Research Institute
15603959 12 Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors.EBI Korea Research Institute of Bioscience and Biotechnology
15324887 2 Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size.EBI National Research Laboratory of Lipid Metabolism and Atherosclerosis
15149654 7 Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis.EBI Korea Research Institute of Bioscience and Biotechnology
11708931 44 5,6-Diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors.EBI Università di Firenze
10890154 14 Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor.EBI Kitasato University
10450977 27 Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT).EBI Azwell Inc.
8691472 49 Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.EBI Rhône-Poulenc Rorer
3100794 6 Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.EBI TBA
27391855 24 Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.BDB Pfizer Inc.
25146964 12 Synthesis, biological evaluation, and molecular docking studies of xanthone sulfonamides as ACAT inhibitors.BDB Second Military Medical University
19256504 18 Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor.BDB AstraZeneca
12725862 9 Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.BDB University of North Carolina at Chapel Hill
17941623 72 Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.BDB St. Jude Research Hospital
17378546 325 Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.BDB St. Jude Research Hospital
15828829 300 Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.BDB University of Mississippi