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140 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27485602 183 Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.EBI Jagiellonian University Medical College
26776359 21 Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists.EBI North-West University
26781932 109 Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists.EBI Merck Research Laboratories
26392370 66 1,3,7-Triethyl-substituted xanthines--possess nanomolar affinity for the adenosine A1 receptor.EBI North-West University
25915162 12 New Frontiers in Selective Human MAO-B Inhibitors.EBI Sapienza Universit£ di Roma
24815000 21 8-Substituted 2-alkynyl-N(9)-propargyladenines as A2A adenosine receptor antagonists.EBI Yamasa Corporation
24164628 186 Adenosine A2A receptor as a drug discovery target.EBI Merck Research Laboratories
9438021 97 Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model.EBI National Institute of Diabetes
23245803 87 Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands.EBI University of Bonn
23281824 118 Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.EBI Universit£ degli Studi di Parma
16392813 329 Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.EBI Universit£ di Bari
22468757 171 Medicinal chemistry of A3 adenosine receptor modulators: pharmacological activities and therapeutic implications.EBI Universit£ di Ferrara
21664729 142 Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.EBI Jagiellonian University Medical College
22486652 44 Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.EBI National Institute of Diabetes and Digestive and Kidney Diseases
20188574 141 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.EBI University of Bonn
19569717 251 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.EBI Institute
18424135 131 Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
15566292 153 Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists.EBI Biogen Idec Inc.
15771453 22 Development of spin-labeled probes for adenosine receptors.EBI University of Bonn
15771443 94 Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.EBI Biogen Idec, Inc.
15267242 54 Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.EBI IIQAB (CSIC)
15084123 24 Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative.EBI University of Bonn
12646033 124 Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.EBI Universit£ di Ferrara
11881988 16 Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.EBI Universit£ di Camerino
11784146 9 2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor.EBI Leiden/Amsterdam Center for Drug Research
12139454 56 Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.EBI University of Bonn
11262085 92 Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.EBI Vrije Universiteit
11170643 171 Design, synthesis, and evaluation of novel A2A adenosine receptor agonists.EBI University of Virginia
11708915 52 Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11170630 46 Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins.EBI Hokkaido University
10649980 52 N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.EBI Universit£ di Camerino
10841798 64 Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.EBI National Institute of Diabetes
10821712 18 Quantized surface complementarity diversity (QSCD): a model based on small molecule-target complementarity.EBI NeoGenesis, Inc.
10212125 14 N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor.EBI Leiden/Amsterdam Center for Drug Research
10212124 26 5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.EBI Leiden University
9703464 40 Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.EBI National Institute of Diabetes
9703463 102 Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists.EBI Universit£ di Ferrara
9667957 5 Nucleosides and nucleotides. 177. 9-(6,7-dideoxy-beta-D-allo-hept-5- ynofuranosyl)adenine: a selective and potent ligand for P3 purinoceptor-like protein.EBI Hokkaido University
9438026 41 5'-substituted adenosine analogs as new high-affinity partial agonists for the adenosine A1 receptor.EBI Leiden/Amsterdam Center for Drug Research
9371242 54 N6-cyclopentyl-3'-substituted-xylofuranosyladenosines: a new class of non-xanthine adenosine A1 receptor antagonists.EBI University of Ghent
8576924 69 Novel N6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A3 adenosine receptors.EBI Universit£ di Ferrara
8917655 72 6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists.EBI National Institute of Diabetes
8863798 52 2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors.EBI Universit£ di Camerino
8709132 92 Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.EBI National Institute of Diabetes
7739005 143 2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.EBI Universit£ di Camerino
7707320 99 Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.EBI National Institute of Diabetes
7562934 38 Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor.EBI Leiden University
7658444 56 2-[N'-(3-arylallylidene)hydrazino]adenosines showing A2a adenosine agonist properties and vasodilation activity.EBI Universit£ di Milano
7752196 103 Structure-activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors.EBI National Institute of Diabetes
7966162 39 Selective ligands for rat A3 adenosine receptors: structure-activity relationships of 1,3-dialkylxanthine 7-riboside derivatives.EBI National Institute of Diabetes
7932588 48 2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.EBI National Institute of Diabetes
1766003 11 Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.EBI University of South Florida
12617898 13 Design, synthesis and binding affinity of 3'-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands.EBI Seoul National University
11392549 45 Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications.EBI NIDDK
10714510 36 The discovery and synthesis of highly potent, A2a receptor agonists.EBI Glaxo Wellcome Medicines Research Centre
10999489 29 2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A1, A2A and A3 receptor subtypes.EBI University of Amsterdam
9871585 23 Diimidazo[1,2-c:4',5'-e]pyrimidines: N6-N1 conformationally restricted adenosines.EBI Griffith University
22104008 64 Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A2A adenosine receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases
20869242 46 Discovery of 2-aminoimidazopyridine adenosine A(2A) receptor antagonists.EBI Ligand Pharmaceuticals, Inc.
20537438 101 Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.EBI East China University of Science and Technology
20116907 15 Synthesis and theoretical studies on energetics of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines--their potential as adenosine receptor ligands.EBI Institute of Chemical Technology
20304654 79 Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process.EBI National University of Singapore
19580286 44 Nucleoside-5'-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5'-nucleotidase.EBI University of Bonn
19140664 82 N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy.EBI Neurocrine Biosciences
18835161 37 2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability.EBI Neurocrine Biosciences
18723354 12 Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues.EBI North-West University
17602796 5 Synthesis and adenosine receptor binding studies of some novel triazolothienopyrimidines.EBI University College of Pharmaceutical Sciences
12398547 9 Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.EBI University of Bonn
9514015 6 Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp.EBI Institut für Biowissenschaften
18329269 77 Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists.EBI Neurocrine Biosciences
18189346 21 Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy.EBI Neurocrine Biosciences
17827019 86 Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands.EBI Jagiellonian University Medical College
17499511 46 N9-benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: synthesis and structure-activity relationships at adenosine A1 and A2A receptors.EBI Jagiellonian University
17381154 4 Neuroprotective principles from Gastrodia elata.EBI National Research Institute of Chinese Medicine
17236762 23 Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.EBI Schering-Plough Research Institute
17125265 49 Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists.EBI Biogen Idec, Inc.
17125264 60 Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists.EBI Biogen Idec, Inc.
16821798 62 A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists.EBI University of Bonn
16153830 64 Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists.EBI Biogen Idec, Inc.
15978806 40 2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: highly potent, orally active, adenosine A2A antagonists. Part 1.EBI Schering-Plough Research Institute
15664803 46 Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists.EBI Biogen Idec Inc.
15341934 28 Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists.EBI Biogen Idec, Inc.
15341933 40 Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles.EBI Biogen Idec, Inc.
15294001 88 Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.EBI Biogen Idec, Inc.
14761205 56 Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.EBI University of Bonn
14741297 46 Synthesis and SAR evaluation of 1,2,4-triazoles as A(2A) receptor antagonists.EBI F Hoffmann-La Roche AG
12270178 74 Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor.EBI CV Therapeutics
12166943 81 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands.EBI Nutrition Research Institute
12166930 21 Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.EBI TBA
12014951 139 Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.EBI National Institute of Diabetes & Digestive & Kidney Diseases
11960496 50 5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.EBI Ghent University
11906291 129 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.EBI University of Bonn
11454470 17 Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor.EBI Leiden/Amsterdam Center for Drug Research
11206456 7 High-pressure synthesis of enantiomerically pure C-6 substituted pyrazol.EBI AstraZeneca R&D Griffith University
11150167 28 Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor.EBI Deakin University
11101355 26 7-Deazaadenines bearing polar substituents: structure-activity relationships of new A(1) and A(3) adenosine receptor antagonists.EBI University of Leipzig
11087559 7 Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography.EBI University of Milano-Bicocca
10737749 182 Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.EBI National Institute of Diabetes
10669571 24 Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists.EBI University of Würzburg
10579811 70 Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.EBI Università degli Studi di Ferrara
10514293 31 Selective A(3) adenosine receptor antagonists: water-soluble 3, 5-diacyl-1,2,4-trialkylpyridinium salts and their oxidative generation from dihydropyridine precursors.EBI National Institute of Diabetes
10479279 20 N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.EBI Novo Nordisk A/S
10450966 16 Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist.EBI Fujisawa Pharmaceutical Co., Ltd.
10447949 27 Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.EBI National Institute of Diabetes
10052977 82 Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2, 4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.EBI National Institute of Diabetes
9873431 18 The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles.EBI Novo Nordisk A/S
9667972 119 Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes.EBI National Institute of Diabetes
9622554 59 Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.EBI Università di Ferrara
9435909 90 Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists.EBI Julius-Maximilians-Universität Würzburg
9258367 99 Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists.EBI National Institute of Diabetes
8863792 22 Synthesis and structure-activity relationship of pyrazolo[3,4-d]pyrimidines: potent and selective adenosine A1 receptor antagonists.EBI Griffith University
8863790 55 Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.EBI National Institute of Diabetes
8691445 70 Chiral pyrrolo[2,3-d]pyrimidine and pyrimido[4,5-b]indole derivatives: structure-activity relationships of potent, highly stereoselective A1-adenosine receptor antagonists.EBI Julius-Maximilians-Universität Würzburg
8676354 42 Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: potent and selective A(2A) adenosine antagonists.EBI Università degli Studi di Ferrara
8576921 63 Interactions of flavonoids and other phytochemicals with adenosine receptors.EBI National Institute of Diabetes
8558508 55 Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists.EBI National Institute of Diabetes
8410976 60 Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.EBI National Institutes of Health
7932565 92 Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.EBI National Institute of Diabetes
7731018 64 Tricyclic heteroaromatic systems. Synthesis and A1 and A2a adenosine binding activities of some 1-aryl-1,4-dihydro-3-methyl[1]benzopyrano[2,3-c] pyrazol-4-ones, 1-aryl-4,9-dihydro-3-methyl-1H-pyrazolo[3,4-b]quinolin-4- ones, and 1-aryl-1H-imidazo[4,5-b]quinoxalines.EBI Università di Firenze
25746740 23 The adenosine receptor affinities and monoamine oxidase B inhibitory properties of sulfanylphthalimide analogues.BDB North-West University
23892098 29 The adenosine A(2A) antagonistic properties of selected C8-substituted xanthines.BDB North-West University, Private Bag X6001, Potchefstroom 2520, South Africa
15831442 46 Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.BDB Taisho Pharmaceutical Co., Ltd
10779381 34 [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.BDB University of Ferrara
9459024 9 Adenosine receptor agonists: synthesis and biological evaluation of the diastereoisomers of 2-(3-hydroxy-3-phenyl-1-propyn-1-yl)NECA.BDB Università di Camerino
8996185 121 Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.BDB Synthélabo Recherche
8022403 113 A binding site model and structure-activity relationships for the rat A3 adenosine receptor.BDB National Institute of Diabetes, Digestive and Kidney Diseases
8012715 38 GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.BDB Glaxo Group Research Ltd.
7582508 13 The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist.BDB ZENECA Pharmaceuticals
3216901 5 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors.BDB Pharmakologisches Institut, Heidelberg
3010074 129 Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.BDB Warner-Lambert/Parke-Davis Pharmaceutical Research
2795469 9 CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity.BDB CIBA-Geigy Corporation
1661335 95 Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins.BDB Center for Bio-Pharmaceutical Sciences
1554381 19 Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase.BDB National Institutes of Diabetes and Digestive and Kidney Diseases
18307293 75 2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure-Activity Relationships.BDB Neuroscience