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293 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26191370 34 Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy.EBI National Institute of Diabetes and Digestive and Kidney Diseases
26048804 57 Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists.EBI Merck Research Laboratories
26046697 46 One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists.EBI Universit£ degli Studi di Ferrara
25969169 54 A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.EBI University of Barcelona
25780876 205 Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.EBI Universit£ degli Studi di Ferrara
25699637 91 5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists.EBI University of Camerino
25633494 128 A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists.EBI National University of Singapore
25422861 78 In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
25701253 23 Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.EBI H. Lundbeck A/S
25686851 54 Novel thiazole-thiophene conjugates as adenosine receptor antagonists: synthesis, biological evaluation and docking studies.EBI B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre
25490054 92 Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease.EBI Monash University (Parkville Campus)
25063944 56 7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A1 and A(2A) adenosine receptors. Molecular modeling and pharmacological studies.EBI Universit£ di Firenze
24972108 256 Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study.EBI Universit£ di Trieste
24969016 16 Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases
24881566 140 Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).EBI GlaxoSmithKline
24863744 15 DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.EBI University of Missouri
25497490 30 1,2,4-triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A3 receptor antagonists. Synthesis, structure-affinity relationships and molecular modeling studies.EBI Universit£ di Firenze
25462223 27 Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.EBI Universit£ degli Studi di Firenze
25349648 29 Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.EBI Merck Research Laboratories
25221664 21 Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases
24815000 21 8-Substituted 2-alkynyl-N(9)-propargyladenines as A2A adenosine receptor antagonists.EBI Yamasa Corporation
24164628 186 Adenosine A2A receptor as a drug discovery target.EBI Merck Research Laboratories
24669958 39 Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.EBI Leiden University
23789857 19 Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.EBI National Institute of Diabetes and Digestive and Kidney Diseases
23597047 5 Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.EBI National Institute of Diabetes and Digestive and Kidney Diseases
23427825 45 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.EBI Universit£ di Firenze
23245803 87 Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands.EBI University of Bonn
23281824 118 Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.EBI Universit£ degli Studi di Parma
23231967 23 Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.EBI University of Santiago de Compostela
23171656 23 Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.EBI Universita' di Firenze
21661720 8 Biophysical mapping of the adenosine A2A receptor.EBI Heptares Therapeutics Limited
20371139 16 Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists.EBI Universidade de A Coru£a
20382540 9 In silico directed chemical probing of the adenosine receptor family.EBI Universidade do Minho
20137957 35 Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists.EBI Universidade de Porto
19682912 80 Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists.EBI Universidade de Santiago de Compostela
19346133 58 Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A(2B) receptor antagonists.EBI Universidade de A Coru£a
16392813 329 Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.EBI Universit£ di Bari
23098605 248 Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.EBI Universit£ di Trieste
22468757 171 Medicinal chemistry of A3 adenosine receptor modulators: pharmacological activities and therapeutic implications.EBI Universit£ di Ferrara
22921089 62 Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.EBI National Institute of Diabetes and Digestive and Kidney Diseases
22827545 11 Identifying novel adenosine receptor ligands by simultaneous proteochemometric modeling of rat and human bioactivity data.EBI Leiden/Amsterdam Center for Drug Research
22738238 29 Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.EBI University of North Carolina at Chapel Hill
22239465 26 Design and characterization of optimized adenosine A2A/A1 receptor antagonists for the treatment of Parkinson's disease.EBI Janssen Research and Development, L.L.C.
21664729 142 Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.EBI Jagiellonian University Medical College
22568637 158 Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists.EBI Universit£ di Ferrara
22563707 27 A prospective cross-screening study on G-protein-coupled receptors: lessons learned in virtual compound library design.EBI Radboud University Nijmegen Medical Centre
22486652 44 Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.EBI National Institute of Diabetes and Digestive and Kidney Diseases
22559880 52 Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.EBI National Institute of Diabetes and Digestive and Kidney Diseases
22677030 29 New chromene scaffolds for adenosine A(2A) receptors: synthesis, pharmacology and structure-activity relationships.EBI Universidade do Minho
22432713 64 Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists.EBI Monash University
22257095 65 3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists.EBI Universit£ di Pisa
22250781 16 Identification of novel adenosine A(2A) receptor antagonists by virtual screening.EBI Heptares Therapeutics Limited
22220592 27 Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design.EBI Heptares Therapeutics Limited
22148921 48 Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-cEBI Cephalon, Inc.
21286238 9 Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine.EBI Ewha Womans University
21210664 74 Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist.EBI H. Lundbeck A/S
20875743 90 Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relaEBI Pfizer Inc.
20931963 112 Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.EBI ASKA Pharmaceutical Co, Ltd
20684563 176 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.EBI H. Lundbeck A/S
20541935 131 4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: drug-like and non-xanthine based A2B adenosine receptor antagonists.EBI Roche Research Center
20408530 98 Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.EBI Universit£ di Pisa
20303771 24 Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A(2A) receptor antagonists.EBI University of Delhi
20188574 141 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.EBI University of Bonn
19569717 251 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.EBI Institute
19282184 195 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.EBI University of Camerino
18637670 80 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists.EBI Leiden/Amsterdam Center for Drug Research
18262425 27 Synthesis of eudistomin D analogues and its effects on adenosine receptors.EBI Hokkaido University
18424135 131 Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
18411049 134 Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines.EBI Vernalis (R&D) Ltd
18407496 127 Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.EBI Vernalis (R&D) Ltd
18406614 56 Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.EBI Vernalis (R&D) Ltd
18321039 144 Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases.EBI CV Therapeutics Inc.
18321038 85 Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
18077171 108 1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists.EBI Universit£ di Ferrara
18258439 69 A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines.EBI Leiden/Amsterdam Center for Drug Research
18226909 162 1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.EBI Universit£ di Bari
17483457 58 A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI Abbott Laboratories
18255292 35 Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists.EBI Ewha Womans University
18249540 28 2,6-Diaryl-4-phenacylaminopyrimidines as potent and selective adenosine A(2A) antagonists with reduced hERG liability.EBI Neurocrine Biosciences
18243699 11 Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease.EBI Pfizer Inc.
18181565 71 Multi-target-directed ligands to combat neurodegenerative diseases.EBI University of Bologna
17933541 145 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.EBI Universit£ di Camerino
17967536 34 Structure-activity relationships of adenosines with heterocyclic N6-substituents.EBI Monash University (Parkville Campus)
17927167 107 5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.EBI Universit£ di Pisa
17306548 84 N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor.EBI Universit£ di Ferrara
17378544 121 Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases
17309246 108 N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor.EBI Universit£ di Camerino
17228880 76 Synthesis and biological evaluation of novel 1-deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide derivatives as useful templates for the development of A2B adenosine receptor agonists.EBI Universit£ di Ferrara
17228876 36 SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase.EBI Pfizer Global Research and Development
17201410 4 Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.EBI University of California-San Francisco
16487705 107 N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists.EBI University of Virginia
16509587 72 Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations.EBI Universit£ degli Studi di Trieste
16366607 81 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.EBI Universit£ di Napoli"Federico II"
16250647 71 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.EBI Universit£ degli Studi di Urbino Carlo Bo
15771447 24 A series of ligands displaying a remarkable agonistic-antagonistic profile at the adenosine A1 receptor.EBI Leiden/Amsterdam Center for Drug Research
15743197 37 Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.EBI Universit£ di Camerino
15481989 70 Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.EBI Universit£ di Ferrara
15341491 62 2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists.EBI CV Therapeutics Inc.
15267242 54 Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.EBI IIQAB (CSIC)
15876531 28 A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential.EBI Novartis Institutes for Biomedical Research
15341938 6 Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor.EBI Ewha Womans University
14998332 328 Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.EBI Universit£ di Ferrara
15239649 24 New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine.EBI University of Leiden
15214785 58 1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies.EBI Universit£ degli Studi di Firenze
12672250 10 N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor.EBI Leiden University
12646033 124 Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.EBI Universit£ di Ferrara
14584936 39 Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists.EBI NIDDK
12383013 44 Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists.EBI Universit£ degli Studi di Genova
11784146 9 2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor.EBI Leiden/Amsterdam Center for Drug Research
12109910 8 N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.EBI Universit£ di Camerino
11462973 47 3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.EBI Universit£ di Pisa
10956189 98 A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives.EBI Universit£ di Pisa
10841798 64 Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.EBI National Institute of Diabetes
10212124 26 5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.EBI Leiden University
9572897 49 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.EBI Universit£ di Camerino
9258366 41 Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors.EBI NIDDK
8258836 3 Synthesis and biological evaluation of N4-substituted imidazo- and v-triazolo[4,5-d]pyridazine nucleosides.EBI University of Rhode Island
11714602 18 7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors.EBI Universit£ di Pisa
11459663 19 Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor.EBI Universit£ di Camerino
11392549 45 Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications.EBI NIDDK
10714510 36 The discovery and synthesis of highly potent, A2a receptor agonists.EBI Glaxo Wellcome Medicines Research Centre
22148859 190 Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A2B adenosine receptor antagonists.EBI University of Ferrara
22104008 64 Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A2A adenosine receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases
22142423 27 Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A2A and A3 adenosine receptor ligands.EBI Ewha Womans University
22204739 136 Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.EBI Universit£ di Ferrara
21214204 100 Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-a]-1,3,5-triazines as Human A(2A) Adenosine Receptor Antagonists with Improved Water Solubility.EBI Universita di Trieste
21988093 316 Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.EBI Pfizer Inc.
21908194 88 Does the combination of optimal substitutions at the C²-, N¿?¿- and N¿?¿-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors?EBI National University of Singapore
21675777 139 New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.EBI Universit£ di Ferrara
21615150 14 Progress in structure based drug design for G protein-coupled receptors.EBI Heptares Therapeutics Limited
21616671 13 Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.EBI Universita' di Firenze
21185184 27 Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold.EBI National Institute of Diabetes and Digestive and Kidney Diseases
21388809 76 Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity.EBI Roche Research Center
21398125 29 Potent and selective adenosine A(2A) receptor antagonists: [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones.EBI Merck Research Laboratories
21186795 142 Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists.EBI University of Santiago de Compostela
21055932 137 Discovery of novel quinolinone adenosine A2B antagonists.EBI Ligand Pharmaceuticals
20973483 2 In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease.EBI Johnson& Johnson Pharmaceutical Research and Development
20943397 18 Molecular modeling study on potent and selective adenosine A(3) receptor agonists.EBI University of Camerino
20937560 54 Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands.EBI Dipartimento di Scienze Farmaceutiche
20869242 46 Discovery of 2-aminoimidazopyridine adenosine A(2A) receptor antagonists.EBI Ligand Pharmaceuticals, Inc.
20801028 14 Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists.EBI NIDDK
20728355 47 Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists.EBI Bayer Schering Pharma AG
20826090 4 Design, synthesis, and binding of homologated truncated 4'-thioadenosine derivatives at the human A3 adenosine receptors.EBI Ewha Womans University
20813948 63 Spiroindolones, a potent compound class for the treatment of malaria.EBI Swiss Tropical and Public Health Institute
20659802 52 Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists.EBI H. Lundbeck A/S
20591666 66 A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.EBI Università degli Studi di Milano
20537438 101 Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.EBI East China University of Science and Technology
20405927 13 Structure-based discovery of A2A adenosine receptor ligands.EBI University of California
20385496 66 Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.EBI Monash University
20347304 68 Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.EBI Johnson& Johnson Pharmaceutical Research and Development
20338760 72 Optimization of arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.EBI Johnson& Johnson Pharmaceutical Research and Development
19501510 15 SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data.EBI Pfizer Global Research and Development
20307065 122 The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.EBI National University of Singapore
20138516 29 Discovery of potent and selective bicyclic A(2B) adenosine receptor antagonists via bioisosteric amide replacement.EBI Rhône-Poulenc Rorer
20137946 81 Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists.EBI Rhône-Poulenc Rorer
19733067 84 Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.EBI Vernalis (R&D) Ltd
20036562 30 2-Dialkynyl derivatives of (N)-methanocarba nucleosides: 'Clickable' A(3) adenosine receptor-selective agonists.EBI NIDDK
20031406 85 Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists.EBI Novartis Institutes for BioMedical Research
20202853 12 Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors.EBI Universidad de M£laga
20095623 56 Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.EBI The Scripps Research Institute
19879151 58 Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists.EBI Ewha Womans University
19632840 43 Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists.EBI Tsukuba Research Institute
19743865 22 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.EBI Universit£ di Firenze
19499950 64 Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.EBI National Institute of Diabetes and Digestive and Kidney Diseases
19839592 37 Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor.EBI University of Camerino
19836950 9 Design, synthesis and biological evaluation of a bivalent micro opiate and adenosine A1 receptor antagonist.EBI Aix-Marseille Universit£
19501513 474 Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.EBI Universit£ di Padova
19481943 23 Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors.EBI Hokkaido University
19375920 30 Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.EBI Ewha Womans University
19362836 83 Antagonists of the human A(2A) receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides.EBI Vernalis (R+D) Ltd.
19398343 48 1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.EBI Universidade de Santiago de Compostela
19317449 76 N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.EBI University of Camerino
19301821 55 Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.EBI Universita di Firenze
19230680 58 Synthesis, biological assays and QSAR studies of N-(9-benzyl-2-phenyl-8-azapurin-6-yl)-amides as ligands for A1 adenosine receptors.EBI Università di Pisa
19181527 61 Synthesis and SAR studies of trisubstituted purinones as potent and selective adenosine A2A receptor antagonists.EBI Pharmacopeia, Inc.
19140664 82 N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy.EBI Neurocrine Biosciences
19109019 30 Potent and selective adenosine A2A receptor antagonists: 1,2,4-Triazolo[1,5-c]pyrimidines.EBI Schering-Plough Research Institute
19072055 224 Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.EBI Vernalis R&D Ltd
19059776 38 Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A(2A) receptor antagonists.EBI Pharmacopeia, Inc.
19036477 32 Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A(1) and A(2A) receptors.EBI University Institute of Pharmaceutical Sciences
19006671 136 Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.EBI Università di Ferrara
18996701 38 Novel potent and highly selective human A(3) adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies.EBI Università di Firenze
18938084 78 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships.EBI Università degli Studi di Bari
18835161 37 2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability.EBI Neurocrine Biosciences
18811138 41 Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.EBI Ewha Womans University
18752961 51 Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system.EBI National Institute of Diabetes and Digestive and Kidney Diseases
18562199 18 Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A2A receptor antagonists.EBI Schering-Plough Research Institute
18558486 26 Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists.EBI Schering-Plough Research Institute
18468446 55 Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.EBI Universita' di Firenze
18045744 16 N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors.EBI Università di Pisa
18329269 77 Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists.EBI Neurocrine Biosciences
18226896 129 Selective, high affinity A(2B) adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines.EBI CV Therapeutics Inc.
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17827019 86 Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands.EBI Jagiellonian University Medical College
17689079 36 Dual acting antioxidant A1 adenosine receptor agonists.EBI Monash University (Parkville Campus)
17665891 60 New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.EBI Università di Firenze
17555308 30 Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists.EBI Ewha Womans University
17539620 13 Novel ergopeptides as dual ligands for adenosine and dopamine receptors.EBI Institut d'Investigacions Biomèdiques August Pi i
17524641 69 3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.EBI GlaxoSmithKline
17499511 46 N9-benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: synthesis and structure-activity relationships at adenosine A1 and A2A receptors.EBI Jagiellonian University
17469811 45 Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.EBI Almirall
17300165 39 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists.EBI Leiden/Amsterdam Center for Drug Research
17236762 23 Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.EBI Schering-Plough Research Institute
17234414 28 3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists.EBI Schering Plough Research Institute
17149867 51 2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.EBI Ghent University
17125265 49 Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists.EBI Biogen Idec, Inc.
17125264 60 Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists.EBI Biogen Idec, Inc.
17045477 136 N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists.EBI CV Therapeutics Inc.
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16821798 62 A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists.EBI University of Bonn
16821770 78 Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.EBI Università degli Studi di Siena
16789747 71 4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies.EBI Università di Firenze
16759111 149 Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.EBI CV Therapeutics Inc.
16722654 15 Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor.EBI Leiden University
16686529 37 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists.EBI Leiden/Amsterdam Center for Drug Research
16458504 37 Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI Columbia University College of Physicians and Surgeons
16392812 75 Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.EBI Ewha Womans University
16392798 46 Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI Columbia University College of Physicians and Surgeons
16366590 12 Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.EBI National Institute of Diabetes and Digestive and Kidney Diseases
16335918 68 1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.EBI Università degli Studi di Firenze
16289820 14 Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety.EBI National Institute of Diabetes and Digestive and Kidney Diseases
16279775 61 Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors.EBI Università degli Studi di Siena
16275090 136 Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists.EBI CV Therapeutics Inc.
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16099648 128 1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.EBI Dipartimento di Scienze Farmaceutiche
16033279 47 New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists.EBI Università di Ferrara
16033270 44 "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
16000006 59 New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists.EBI Università di Ferrara
15808481 21 6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists.EBI Schering-Plough Research Institute
15771421 96 (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
15664822 101 The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma.EBI CV Therapeutics, Inc.
15588088 58 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.EBI Leiden/Amsterdam Center for Drug Research
15294001 88 Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.EBI Biogen Idec, Inc.
15203160 119 Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma.EBI Otsuka Pharmaceutical Factory, Inc.
15163184 227 Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.EBI Università di Pisa
15149696 44 Comparison of inhibitory activity of isomeric triazolopyridine derivatives towards adenosine receptor subtypes or do similar structures reveal similar bioactivities?EBI F. Hoffmann-LaRoche Ltd
15109629 17 Facile synthesis of fused 1,2,4-triazolo[1,5-c]pyrimidine derivatives as human adenosine A3 receptor ligands.EBI Otsuka Pharmaceutical Factory, Inc.
15006389 33 2-(N-acyl) and 2-N-acyl-N(6)-substituted analogues of adenosine and their affinity at the human adenosine receptors.EBI Inotek Pharmaceuticals Corporation
14741297 46 Synthesis and SAR evaluation of 1,2,4-triazoles as A(2A) receptor antagonists.EBI F Hoffmann-La Roche AG
13678407 57 Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.EBI Università degli Studi di Trieste
12408713 54 Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists.EBI Università di Pisa
12270178 74 Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor.EBI CV Therapeutics
12166943 81 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands.EBI Nutrition Research Institute
12166930 21 Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.EBI TBA
12139445 36 Pyrido[2,1-f]purine-2,4-dione derivatives as a novel class of highly potent human A(3) adenosine receptor antagonists.EBI Instituto de Química Médica (CSIC)
12039562 15 2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors.EBI University of Virginia
11906291 129 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.EBI University of Bonn
11831890 278 Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.EBI Università degli Studi di Ferrara
11754583 112 7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility.EBI Università degli Studi di Ferrara
11549462 11 Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands.EBI Facoltà di Farmacia dell'Università degli Studi di Genova
11495585 16 Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies.EBI Università degli Studi di Ferrara
11170626 55 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.EBI Eisai Company, Ltd.
11123985 176 Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen.EBI Università degli Studi di Ferrara
11087559 7 Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography.EBI University of Milano-Bicocca
10956220 93 Synthesis and structure-activity relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.EBI Universita' di Firenze
10737749 182 Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.EBI National Institute of Diabetes
10737748 81 1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.EBI Universita' di Firenze
10698437 7 Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors.EBI Università di Ferrara
10669571 24 Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists.EBI University of Würzburg
10579811 70 Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.EBI Università degli Studi di Ferrara
10476879 52 Selective A1-adenosine receptor antagonists identified using yeast Saccharomyces cerevisiae functional assays.EBI Cadus Pharmaceutical Corporation
9622554 59 Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.EBI Università di Ferrara
8863790 55 Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.EBI National Institute of Diabetes
8071944 37 8-Azaxanthine derivatives as antagonists of adenosine receptors.EBI Università di Camerino
2724296 56 Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.EBI National Institutes of Health
1331453 75 Effects of alkyl substitutions of xanthine skeleton on bronchodilation.EBI Hokuriku University
27439119 16 Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor AgonistsBDB Uppsala University
27282729 22 4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor.BDB UniversitÓ di Napoli Federico II
26851736 160 Synthesis and pharmacological characterization of novel xanthine carboxylate amides as A2A adenosine receptor ligands exhibiting bronchospasmolytic activity.BDB Panjab University
26042529 21 Development of novel adenosine receptor ligands based on the 3-amidocoumarin scaffold.BDB Universidade do Porto
23480235 20 N-[9-(ortho-fluorobenzyl)-2-phenyl-8-azapurin-6-yl]-amides as potent and selective ligands for A1 adenosine receptors.BDB Universit£ di Pisa
8996189 24 Cloning, expression and pharmacological characterization of rabbit adenosine A1 and A3 receptors.BDB Pfizer Inc.
15734651 135 A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists.BDB National Institutes of Health
19695884 156 Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides.BDB Vernalis (R&D) Ltd
18947224 54 Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson's Disease.BDB Neurocrine Bioscience
18269230 87 Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine as Novel, Potent, and Selective A3 Adenosine Receptor Antagonists.BDB Universita di Napoli
18307293 75 2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure-Activity Relationships.BDB Neuroscience
18307292 34 2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 1. Structure-Activity Relationships and Optimization of Heterocyclic Substituents.BDB Neuroscience