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16 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
16451077 86 Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.EBI Pfizer Inc.
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
15482914 25 Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750.EBI Pfizer Inc.
14998318 112 Selective optimization of side activities: another way for drug discovery.EBI Prestwick Chemical Inc.
11585444 295 From hit to lead. Analyzing structure-profile relationships.EBI F-59000 Lille
17524641 69 3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.EBI GlaxoSmithKline
16722631 87 An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.EBI Predix Pharmaceuticals Ltd.
16392798 46 Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI Columbia University College of Physicians and Surgeons
15771448 187 Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.EBI Johnson & Johnson Pharmaceutical Research & Development
15341484 159 Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.EBI Merck KGaA
15341483 110 Indolebutylamines as selective 5-HT(1A) agonists.EBI Merck KGaA
10715142 35 alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor.EBI The R. W. Johnson Pharmaceutical Research Institute
8558529 195 Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
1681106 27 Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds.EBI Pfizer Inc.