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157 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26475518 19 Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor.EBI City University of New York
25703296 1 Novel 1-(2-aryl-2-adamantyl)piperazine derivatives with antiproliferative activity.EBI University of Athens
25658964 69 Synthesis and structure-activity relationship study of a new series of selectives(1) receptor ligands for the treatment of pain: 4-aminotriazoles.EBI Esteve
25602932 22 Synthesis and pharmacological evaluation of benzannulated derivatives as potent and selective sigma-1 protein ligands.EBI Univ Lille Nord de France
25489882 63 Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
24863744 15 DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.EBI University of Missouri
25462240 26 Carboline- and phenothiazine-derivated heterocycles as potent SIGMA-1 protein ligands.EBI Univ Lille Nord de France
24800940 146 Identification of a new selective dopamine D4 receptor ligand.EBI Florida A&M University
24821398 42 Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues ass2 receptor ligands.EBI Washington University School of Medicine
24690494 92 Antagonists of the kappa opioid receptor.EBI The Scripps Research Institute
24617836 33 Synthesis, pharmacological evaluation, ands1 receptor interaction analysis of hydroxyethyl substituted piperazines.EBI University of M£nster
23734634 33 Thes2 receptor: a novel protein for the imaging and treatment of cancer.EBI Washington University School of Medicine
24735647 34 Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(1H)-quinolinone scaffold as a potential analgesic.EBI Huazhong University of Science and Technology
24365159 35 The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.EBI University of Missouri
24331758 7 Involvement of apoptosis and autophagy in the death of RPMI 8226 multiple myeloma cells by two enantiomeric sigma receptor ligands.EBI University of Greifswald
23964901 3 Structure of thes1 receptor and its ligand binding site.EBI Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster
24147864 6 Synthesis and evaluation in monkey of [(18)F]4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([(18)F]FIMX): a promising radioligand for PET imaging of brain metabotropic glutamate receptor 1 (mGluR1).EBI National Institute of Mental Health
24140950 6 Design, synthesis and receptor affinity of novel conformationally restricteds ligands based on the [4.3.3]propellane scaffold.EBI Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster
24100077 5 Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.EBI Universit£ degli Studi di Bari 'Aldo Moro'
24075145 17 Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate.EBI GlaxoSmithKline Medicines Research Centre
24095744 8 New combination of pharmacophoric elements of potents1 ligands: design, synthesis ands receptor affinity of aminoethyl substituted tetrahydrobenzothiophenes.EBI Universit£t M£nster
23816046 8 Synthesis and in vivo evaluation of [(18)F]2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione ([(18)F]FECUMI-101) as an imaging probe for 5-HT1A receptor agonist in nonhuman primates.EBI Columbia University Medical Center
23601816 33 Synthesis and biological evaluation of Esaprazole analogues showings1 binding and neuroprotective properties in vitro.EBI Nensius Research A/S
23582449 20 Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.EBI Institute of Organic Synthesis
23403082 28 Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.EBI Broad Institute of MIT and Harvard
23566245 15 Synthesis and evaluation of novel (18)F-labeled spirocyclic piperidine derivatives ass1 receptor ligands for positron emission tomography imaging.EBI Key Laboratory of Radiopharmaceuticals Beijing Normal University
23560650 46 Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selectives1 receptor ligands.EBI Esteve
23470245 11 Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity.EBI University of Catania
7990111 35 Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor.EBI University of North Carolina
1317923 48 Spiropiperidines as high-affinity, selective sigma ligands.EBI Merck Sharp and Dohme Research Laboratories
1317922 48 Benz[f]isoquinoline analogues as high-affinity sigma ligands.EBI Merck Sharp and Dohme Research Laboratories
20067271 11 Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane.EBI Universit£ di Camerino
23094992 6 New adamantane phenylalkylamines withs-receptor binding affinity and anticancer activity, associated with putative antagonism of neuropathic pain.EBI National and Kapodistrian University of Athens
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
22784008 100 Synthesis and biological evaluation of the 1-arylpyrazole class ofs(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).EBI Esteve
22386241 46 Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents.EBI SK Biopharmaceuticals
22850210 20 Exploration of ring size in a series of cyclic vicinal diamines withs1 receptor affinity.EBI The University of Sydney
22515405 39 Thiophene bioisosteres of spirocyclics receptor ligands: relationships between substitution pattern ands receptor affinity.EBI Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
22739089 42 Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups.EBI Washington University
22313227 78 Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.EBI National Institute of Mental Health
22512908 6 Synthesis,s1,s2-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes.EBI National and Kapodistrian University of Athens
21207959 69 Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.EBI National Institute of Mental Health
17483457 58 A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI Abbott Laboratories
16821774 86 Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists.EBI Ono Pharmaceutical Co., Ltd.
16033255 134 Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening.EBI University of Innsbruck
15634021 113 Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.EBI Universit£ di Modena and Reggio Emilia
7241506 40 New analgesic drugs derived from phencyclidine.EBI TBA
12801223 71 Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.EBI NIDA-IRP
12747784 28 Synthesis of chiral 1-[omega-(4-chlorophenoxy)alkyl]-4-methylpiperidines and their biological evaluation at sigma1, sigma2, and sterol delta8-delta7 isomerase sites.EBI Universit£ di Bari
12383018 46 Novel sigma receptor ligands. Part 2. SAR of spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] with carbon substituents in position 3.EBI Pharmazeutisches Institut der Universit£t Freiburg
12036376 4 Synthesis of (+)-cis-N-(4-isothiocyanatobenzyl)-N-normetazocine, an isothiocyanate derivative of N-benzylnormetazocine as acylant agent for the sigma(1) receptor.EBI University of Catania
11170639 73 Current and novel approaches to the drug treatment of schizophrenia.EBI Merck Sharp and Dohme
11585444 295 From hit to lead. Analyzing structure-profile relationships.EBI F-59000 Lille
10602703 73 A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.EBI Warner-Lambert Company
10508444 58 Synthesis and SAR of 1-alkyl-2-phenylethylamine derivatives designed from N,N-dipropyl-4-methoxy-3-(2-phenylethoxy)phenylethylamine to discover sigma(1) ligands.EBI Taisho Pharmaceutical Company Ltd.
10508425 68 Mixture-based synthetic combinatorial libraries.EBI Torrey Pines Institute for Molecular Studies
9703460 52 Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists.EBI National Taiwan University
9572883 32 (+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties.EBI University of Catania
9083484 84 New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.EBI Cooperation Pharmaceutique Fran�aise
9435903 14 Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter.EBI National Institute on Drug Abuse-Intramural Research Program
9435897 70 Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers.EBI Cambridge NeuroScience, Inc.
8941383 146 Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).EBI National Institute of Diabetes and Digestive and Kidney Diseases
8568804 42 New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives.EBI Universit£ di Bari
7707315 58 3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873).EBI Hoechst-Roussel Pharmaceuticals Inc
7636860 48 Synthesis and sigma binding properties of 2'-substituted 5,9 alpha-dimethyl-6,7-benzomorphans.EBI Research Triangle Institute
7905926 66 Piperidinyltetralin sigma ligands.EBI DuPont Merck Pharmaceutical Company
7932569 116 Antipodal alpha-N-(methyl through decyl)-N-normetazocines (5,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphans): in vitro and in vivo properties.EBI Virginia Commonwealth University
8295220 18 A new approach to the design of sigma-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine-related polyamines at sigma-1 and sigma-2 receptor subtypes.EBI National Institutes of Diabetes and Digestive and Kidney Diseases
8027978 50 Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds.EBI Albany Molecular Research
8098066 39 Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8496936 16 Synthesis and binding characteristics of potential SPECT imaging agents for sigma-1 and sigma-2 binding sites.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8102651 51 Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity.EBI University of North Carolina
8360875 23 Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds.EBI National Institute of Diabetes and Digestive and Kidney Diseases
1469697 37 Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites.EBI National Institute on Drug Abuse
1361578 65 Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.EBI Bristol-Myers Squibb Co.
1319493 27 Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.EBI National Institute of Diabetes and Digestive and Kidney Diseases
1648139 34 Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors.EBI Virginia Commonwealth University
1848295 33 Identification and exploitation of the sigma-opiate pharmacophore.EBI Virginia Commonwealth University
1975275 113 Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor.EBI University of Oregon
2172538 58 Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.EBI National Institute of Diabetes and Digestive and Kidney Diseases
2213824 20 Thiazole as a carbonyl bioisostere. A novel class of highly potent and selective 5-HT3 receptor antagonists.EBI Pfizer central Research
2547074 16 Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.EBI National Institute of Digestive
15026077 13 Synthesis of potent sigma-1 receptor ligands via fragmentation of dextromethorphan.EBI UCB Research, Inc
21962578 3 Synthesis and in vivo evaluation of [18F]N-(2-benzofuranylmethyl)-N'-[4-(2-fluoroethoxy)benzyl]piperazine, a novels1 receptor PET imaging agent.EBI The University of Sydney
21899931 27 Synthesis and pharmacological evaluation of indole-based sigma receptor ligands.EBI The University of Mississippi
21229983 19 Discovery and biological characterization of (2R,4S)-1'-acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) receptor antagonist clinical candidate.EBI GlaxoSmithKline Medicines Research Centre
20965735 5 Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists.EBI Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster
20493718 16 Synthesis and characterization of N,N-dialkyl and N-alkyl-N-aralkyl fenpropimorph-derived compounds as high affinity ligands for sigma receptors.EBI University of Wisconsin School of Medicine and Public Health
19875205 4 Sigma-1 ligands: Tic-hydantoin as a key pharmacophore.EBI UMR CNRS 8161-Universit£ Lille Nord de France-Institut Pasteur de Lille
19954972 14 Oxo-bridged isomers of aza-trishomocubane sigma (sigma) receptor ligands: Synthesis, in vitro binding, and molecular modeling.EBI University of Sydney
19243173 29 Dancing of the second aromatic residue around the 6,8-diazabicyclo[3.2.2]nonane framework: influence on sigma receptor affinity and cytotoxicity.EBI Institut fur Pharmazeutische und Medizinische Chemie der Westfalischen Wilhelms-Universitat Munster
18817368 57 Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.EBI Merck Research Laboratories
17571866 49 Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.EBI National Institute of Mental Health
16722631 87 An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.EBI Predix Pharmaceuticals Ltd.
16458504 37 Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI Columbia University College of Physicians and Surgeons
16392798 46 Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI Columbia University College of Physicians and Surgeons
16140011 10 Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective sigma1 ligands. Part 1.EBI Université de Lille II
16140009 31 Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective sigma1 ligands. Part 2.EBI Université de Lille II
15084129 52 4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity.EBI Università di Bari
15081012 19 Thioxanthene-derived analogs as sigma(1) receptor ligands.EBI Virginia Commonwealth University
14684327 60 Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands.EBI Wake Forest University School of Medicine
12639573 9 1,4-dibenzylpiperazines possess anticocaine activity.EBI University of Maryland
12570387 60 Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.EBI Università degli Studi di Bari
11934576 82 Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands.EBI Université de Lille 2
11784148 81 Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1.EBI Pharmazeutisches Institut der Universität Freiburg
11728186 46 Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent sigma1 receptor ligands.EBI Wake Forest University School of Medicine
11356115 108 Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.EBI Wake Forest University School of Medicine
10636233 3 A sigma-1 receptor selective analogue of BD1008. A potential substitute for (+)-opioids in sigma receptor binding assays.EBI University of Maryland
10579824 36 Asymmetric synthesis of 9-alkyl-2-benzyl-6,7-benzomorphans: characterization as novel sigma receptor ligands.EBI Research Triangle Institute
10425095 26 Hydroxylated decahydroquinolines as ligands for the vesicular acetylcholine transporter: synthesis and biological evaluation.EBI University of Minnesota
9876110 58 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).EBI Centro de Investigación Grupo Ferrer
9873527 12 Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds.EBI Institute for Molecular Studies
9836612 32 Characterization of novel N,N'-disubstituted piperazines as sigma receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
9651150 18 Substituted halogenated arylsulfonamides: a new class of sigma receptor binding tumor imaging agents.EBI The George Washington University Medical Center
9632369 45 Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptor ligands.EBI Wake Forest University School of Medicine
9572880 44 1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.EBI University of Camerino
9544213 9 Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives.EBI University of Louvain
9397171 81 N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.EBI University of Minnesota
9171875 32 Halogenated 4-(phenoxymethyl)piperidines as potential radiolabeled probes for sigma-1 receptors: in vivo evaluation of [123I]-1-(iodopropen-2-yl)-4-[(4-cyanophenoxy)methyl]pip eri dine.EBI ANSTO
9057857 169 Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8784455 15 Synthesis and evaluation of aryl-substituted N-(arylethyl)-N-methyl-2-(1-pyrrolidinyl)ethylamines and corresponding arylacetamides for sigma receptor affinity.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8426363 134 Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled sigma binding site.EBI Scios-Nova Inc.
8295213 59 Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist.EBI Cambridge NeuroScience, Inc.
8164264 56 Structural features important for sigma 1 receptor binding.EBI Virginia Commonwealth University
8021913 9 Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells.EBI George Washington University Medical Center
7932540 38 A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
7932535 40 Synthesis and opioid activity of 7-oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-ols.EBI National Taiwan University
7902870 24 Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors.EBI Warner-Lambert Company
7902869 47 N-(1-arylpropionyl)-4-aryltetrahydropyridines, a new class of high-affinity selective sigma receptor ligands.EBI New York University
7853349 19 (+)-cis-N-(para-, meta-, and ortho-substituted benzyl)-N-normetazocines: synthesis and binding affinity at the [3H]-(+)-pentazocine-labeled (sigma 1) site and quantitative structure-affinity relationship studies.EBI Research Triangle Institute
7837240 19 Preparation of 18F-labeled muscarinic agonist with M2 selectivity.EBI National Institutes of Health
7699710 84 High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.EBI Università di Bari
7636861 32 Synthesis and sigma binding properties of 1'- and 3'-halo- and 1',3'-dihalo-N-normetazocine analogues.EBI Research Triangle Institute
7490727 72 (E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype.EBI National Institute of Diabetes and Digestive and Kidney Diseases
1681106 27 Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds.EBI Pfizer Inc.
1674541 16 Conformational properties of semirigid antipsychotic drugs: the pharmacophore for dopamine D-2 antagonist activity.EBI Harvard Medical School
1662725 48 Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity sigma ligands.EBI Virginia Commonwealth University
1656044 18 Synthesis and receptor binding of enantiomeric N-substituted cis-N-[2-(3,4-dichlorophenyl)ethyl]-2-(1-pyrrolidinyl)cyclohexylamines as high-affinity sigma receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
1648140 14 Radiosynthesis of sigma receptor ligands for positron emission tomography: 11C- and 18F-labeled guanidines.EBI Institutions
1469699 12 Synthesis, configuration, and activity of isomeric 2-phenyl-2-(N-piperidinyl)bicyclo[3.1.0]hexanes at phencyclidine and sigma binding sites.EBI National Institute of Diabetes and Digestive and Kidney Diseases
1447735 17 Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes.EBI National Institute of Diabetes and Digestive and Kidney Diseases
1315869 231 (Aminoalkoxy)chromones. Selective sigma receptor ligands.EBI Nova Pharmaceutical Corporation
1310114 30 Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases