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80 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26463133 22 Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide.EBI Institute of Advanced Chemistry of Catalonia (IQAC-CSIC)
26241877 7 Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route.EBI Pharmaleads
26386821 15 Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase.EBI Shandong University
25982416 43 Exploring S1 plasticity and probing S1' subsite of mammalian aminopeptidase N/CD13 with highly potent and selective aminobenzosuberone inhibitors.EBI Universit£ de Haute Alsace
25192493 57 Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.EBI University of Athens
24927250 18 New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment.EBI Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France.
24755524 60 Design, synthesis and preliminary evaluation ofa-sulfonyl┐-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors.EBI Shandong University
24055078 14 Synthesis of amino-hydroxy-benzocycloheptenones as potent, selective, non-peptidic dinuclear zinc metalloaminopeptidase inhibitors.EBI Universit£ de Haute Alsace
23860593 17 Novel▀-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN).EBI Shandong University
23664876 1 Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor.EBI The University of Oklahoma Health Sciences Center
23528299 4 Discovery of a synthetic Aminopeptidase N inhibitor LB-4b as a potential anticancer agent.EBI Shandong University
23510562 30 Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN).EBI Shandong University
23428964 9 Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy.EBI Universit£ de Haute-Alsace
23453219 29 Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).EBI Shandong University
19757839 26 The replacement of His(4) in angiotensin IV by conformationally constrained residues provides highly potent and selective analogues.EBI Vrije Universiteit Brussel
23176597 14 Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors.EBI INSERM
22796349 34 Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors.EBI Universit£ de Haute Alsace
22901392 27 A novel aminopeptidase N inhibitor developed by virtual screening approach.EBI Shandong Academy of Sciences
21780776 40 Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry.EBI Wroclaw University of Technology
22607877 38 Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors.EBI Shandong University
22224710 44 Structure-activity relationship study of opiorphin, a human dual ectopeptidase inhibitor with antinociceptive properties.EBI Institute of Advanced Chemistry of Catalonia (IQAC-CSIC)
19822427 21 Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity.EBI Loyola University
19339187 49 Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II).EBI Shandong University
19329328 42 Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I).EBI Shandong University
17331715 19 Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors.EBI Korea Research Institute of Chemical Technology
15582436 7 N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity.EBI Sejong University
12801228 18 The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity.EBI Wroclaw University of Technology
11585456 8 Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.EBI INSERM
10753476 84 Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities.EBI INSERM
10602705 82 Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme.EBI INSERM
7909847 33 Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors.EBI INSERM
1348542 23 Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.EBI INSERM
1347791 35 Analgesic dipeptide derivatives. 7. 3,7-Diamino-2-hydroxyheptanoic acid (DAHHA) containing dipeptide analogues of the analgesic compound H-Lys-Trp(Nps)-OMe.EBI Instituto de Qu£mica M£dica
3184126 46 Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues.EBI University of Wisconsin
3897541 27 New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties.EBI TBA
6142952 41 Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes.EBI TBA
12873488 11 Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors.EBI Universit£ de Lille 2
10098663 37 Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs.EBI University of Tokyo
10386926 29 Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor.EBI INSERM
22206607 9 Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation.EBI Central South University
21911297 40 Design, synthesis and biological evaluation of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as aminopeptidase N/CD13 inhibitors.EBI Shan Dong University
21843945 36 A novel amino-benzosuberone derivative is a picomolar inhibitor of mammalian aminopeptidase N/CD13.EBI Universit£ de Haute Alsace
21802307 64 Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine.EBI Shandong University
21476495 31 Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis.EBI Uppsala University
21306895 46 Discovery ofß-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors.EBI Korea Research Institute of Chemical Technology
18458130 8 Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors.EBI Trinity College
21292493 23 Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13.EBI Laboratoire de Chimie Organique et Bioorganique, FRE3252, ENSCMu, F-68093 Mulhouse Cedex, France.
21194957 27 Design, synthesis and biological evaluation of novel L-lysine ureido derivatives as aminopeptidase N inhibitors.EBI Shandong University
21047126 51 Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP).EBI Uppsala University
20637634 48 Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione.EBI Shandong University
20129718 32 Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Structure-based design, chemistry and activity evaluation. II.EBI Shandong University
20347318 49 New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13.EBI Wroclaw University of Technology
19969464 56 Design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase N/CD13 inhibitors.EBI Shandong University
19782572 62 Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13.EBI Shandong University
19683842 27 Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Design, chemistry and activity evaluation. Part I.EBI Shandong University
19454370 52 Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors.EBI Shandong University
19423354 26 Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors.EBI Shandong University
19299146 33 Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors.EBI Shandong University
18996018 42 Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN).EBI Shandong University
18718763 50 Synthesis of new sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.EBI Shandong University
18571419 24 Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold.EBI ShanDong University
18556208 48 Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2.EBI Uppsala University
18524593 12 First synthesis of alpha-aminoalkyl-(N-substituted)thiocarbamoyl-phosphinates: inhibitors of aminopeptidase N (APN/CD13) with the new zinc-binding group.EBI Wroc£?aw University of Technology
18440232 38 Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.EBI Shandong University
18362041 59 Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors.EBI Shandong University
17433673 44 Novel 3-galloylamido-N'-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors.EBI Shandong University
17326615 49 Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.EBI Inserm
17270439 23 Novel hydroxamic acid-related phosphinates: inhibition of neutral aminopeptidase N (APN).EBI Wroclaw University of Technology
17070058 15 A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening.EBI University of Lille 2
12930151 1 Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13.EBI INSERM
10090787 25 Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors.EBI University of Antwerp (UIA)
7915326 28 Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols.EBI INSERM
2738884 27 New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties.EBI INSERM
1738140 26 alpha-Keto amide inhibitors of aminopeptidases.EBI University of Wisconsin-Madison
27113097 7 Design, synthesis, and biological characterization of tamibarotene analogs as anticancer agents.BDB Shandong University
16844380 76 Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors.BDB ENSCMu
17850059 195 N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.BDB Montana State University