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126 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26331986 6 Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae.EBI Institute of Oriental Medicine
25890697 6 Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions.EBI Punjabi University
26005026 25 Synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro[fluorene-9,5'-imidazolidine]-2',4'-diones.EBI Quaid-i-Azam University
25695864 35 Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold.EBI Slovak Academy of Sciences
25375908 9 Targeting aldose reductase for the treatment of diabetes complications and inflammatory diseases: new insights and future directions.EBI Universit£ degli Studi di Messina
25152999 9 20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng.EBI Kyushu University
24819954 16 Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents.EBI University of Messina
24780598 7 Synthesis and biological evaluation of some new pyrazoline substituted benzenesulfonylurea/thiourea derivatives as anti-hyperglycaemic agents and aldose reductase inhibitors.EBI Jamia Hamdard (Hamdard University)
40025 4 Nicotinamide adenine dinucleotide phosphate-decanaldehyde adduct as an inhibitor of beef brain NADP-linked aldehyde reductase.EBI TBA
24630695 11 Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation.EBI Aristotle University of Thessaloniki
24275248 6 Synthesis and biological evaluation of new epalrestat analogues as aldose reductase inhibitors (ARIs).EBI CSIR-Indian Institute of Chemical Technology
24071447 39 Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10.EBI Gifu Pharmaceutical University
23891165 12 1-Hydroxypyrazole as a bioisostere of the acetic acid moiety in a series of aldose reductase inhibitors.EBI Aristotle University of Thessaloniki
23683835 21 Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors.EBI Xiangtan University
23312612 8 Synthesis of derivatives of the keto-pyrrolyl-difluorophenol scaffold: some structural aspects for aldose reductase inhibitory activity and selectivity.EBI Aristotle University of Thessaloniki
18585047 59 QSAR prediction of inhibition of aldose reductase for flavonoids.EBI INIFTA (UNLP, CCT La Plata-CONICET)
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
22224640 53 Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.EBI Oxagen Ltd.
21561086 21 Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.EBI Gifu Pharmaceutical University
22263837 262 Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17ß-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.EBI University of Pennsylvania
22264115 19 Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities.EBI Korean Institute of Oriental Medicine (KIOM)
20452228 13 Identification of new non-carboxylic acid containing inhibitors of aldose reductase.EBI University of Messina
19670875 19 Inhibitors of aldose reductase and formation of advanced glycation end-products in moutan cortex (Paeonia suffruticosa).EBI Chungnam National University
18492610 9 Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives.EBI Universit£ di Messina
18298080 10 Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity.EBI Institute of Oriental Medicine
14510595 25 Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis.EBI Kyoto Pharmaceutical University
18165015 18 Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.EBI Monash University
18087047 3 Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.EBI Universitat Aut£noma de Barcelona
17512196 8 Evaluation of in vitro aldose redutase inhibitory activity of 5-arylidene-2,4-thiazolidinediones.EBI Universit£ di Messina
15456251 8 Soft docking and multiple receptor conformations in virtual screening.EBI University of California-San Francisco
12540241 5 Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.EBI Aristotle University of Thessaloniki
11356107 16 Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis.EBI Sankyo Co., Ltd.
10737739 11 Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants.EBI National Eye Institute
10354396 32 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors.EBI Universit£ di Modena
8893834 30 Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors.EBI TBA
8145228 15 Molecular modeling studies of aldose reductase inhibitors.EBI National Eye Institute
8027986 30 Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.EBI Wyeth-Ayerst Research
1613744 68 Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.EBI Pfizer Inc.
1900532 44 A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.EBI Pfizer Inc.
1956041 28 Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors.EBI Alcon Laboratories, Inc.
2113948 11 Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones.EBI Pfizer Central Research
2491890 62 N- and 2-substituted N-(phenylsulfonyl)glycines as inhibitors of rat lens aldose reductase.EBI Auburn University
3121857 116 Spiro hydantoin aldose reductase inhibitors.EBI Pfizer Central Research
3086557 19 Synthesis and rat lens aldose reductase inhibitory activity of some benzopyran-2-ones.EBI TBA
3093680 13 Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives.EBI TBA
22104435 54 Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-ß-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1.EBI University of Toyama
22261024 21 Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase.EBI King's College London
22236472 51 Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10.EBI Gifu Pharmaceutical University
22209731 81 Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii.EBI Kinki University
22036211 4 1,2-Benzothiazine 1,1-dioxide carboxylate derivatives as novel potent inhibitors of aldose reductase.EBI Beijing Institute of Technology
22047696 17 Structure-activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors.EBI Sepuluh Nopember Institute of Technology
22037047 1 (2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature.EBI Slovak Academy of Sciences
21944852 79 Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.EBI AstraZeneca R&D Charnwood
21916510 167 Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.EBI Merck Serono S.A.
21531055 14 Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications.EBI Universit£ di Messina
19250825 4 Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.EBI The Institute for Diabetes Discovery, LLC
21288726 7 Structure-activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity and selectivity.EBI Aristotle University of Thessaloniki
21256748 8 Furoxan nitric oxide donor coupled chrysin derivatives: synthesis and vasculoprotection.EBI Central South University
21129963 23 In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.EBI University of Messina
20936791 32 A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity.EBI Aristotle University of Thessaloniki
20805028 32 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2.EBI University of Toyama
20304656 31 Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10.EBI Gifu Pharmaceutical University
20395149 11 Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin.EBI Central South University
20071057 4 Evaluation of aldose reductase inhibition and docking studies of 6'-nitro and 6',6''-dinitrorosmarinic acids.EBI National Hellenic Research Foundation
19962793 14 Synthesis and biological evaluation of [1,2,4]triazino[4,3-a] benzimidazole acetic acid derivatives as selective aldose reductase inhibitors.EBI Institute of Pharmaceutical Sciences
20189816 8 Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole.EBI Aristotle University of Thessaloniki
8699190 9 Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes.EBI Fukuyama University
18976928 1 Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols.EBI Central Food Technological Research Institute
18565754 4 Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones.EBI Ankara University
18313804 6 Synthesis and aldose reductase inhibitory activity of some new chromonyl-2,4-thiazolidinediones.EBI Ankara University
18267362 9 Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors.EBI Aristotle University of Thessaloniki
12193020 9 New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume.EBI Kyoto Pharmaceutical University
17870536 28 Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.EBI Università di Modena e Reggio Emilia
17845019 21 Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity.EBI Università di Pisa
16753296 25 Discovery of potent CRTh2 (DP2) receptor antagonists.EBI AstraZeneca R&D Charnwood
16107153 10 Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.EBI Monash University (Parkville Campus)
15317464 4 High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor.EBI Monash University (Parkville Campus)
15115413 4 [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone as a bioisostere of a carboxylic acid aldose reductase inhibitor.EBI Aristotle University of Thessaloniki
14667216 48 Rational design of an indolebutanoic acid derivative as a novel aldose reductase inhibitor based on docking and 3D QSAR studies of phenethylamine derivatives.EBI Yonsei University
14613323 10 Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product.EBI Instituto Biomar, S.A.
12672241 37 Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives.EBI Università di Pisa
11728182 28 [1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors.EBI Università di Pisa
10882376 7 A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.EBI Rational Drug Design Laboratories
10354397 28 Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors.EBI Dipartimento di Scienze Farmaceutiche
9822541 15 Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors.EBI EP811-CNRS
9767647 47 Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners.EBI Dainippon Pharmaceutical Company, Ltd.
9057855 33 Highly selective aldose reductase inhibitors. 3. Structural diversity of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids.EBI Nippon Zoki Pharmaceutical Company Ltd.
8627616 12 Highly selective aldose reductase inhibitors. 1. 3-(Arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic acids.EBI Nippon Zoki Pharmaceutical Company, Ltd.
8027987 1 N-substituted spirosuccinimide, spiropyridazine, spiroazetidine, and acetic acid aldose reductase inhibitors derived from isoquinoline-1,3-diones. 2.EBI Wyeth-Ayerst Research Inc.
6818344 14 Spiro oxazolidinedione aldose reductase inhibitors.EBI TBA
6779009 1 Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids.EBI TBA
6422042 3 N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.EBI TBA
3934383 6 Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil.EBI TBA
3925146 43 Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.EBI TBA
3114491 18 Novel inhibitors of rat lens aldose reductase: N-[[(substituted amino)phenyl]sulfonyl]glycines.EBI TBA
3097318 4 Synthesis and biological evaluation of irreversible inhibitors of aldose reductase.EBI TBA
3097317 19 Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids.EBI TBA
3084783 6 Design and synthesis of 2-(arylamino)-4(3H)-quinazolinones as novel inhibitors of rat lens aldose reductase.EBI TBA
2539477 5 Computer-assisted design and synthesis of novel aldose reductase inhibitors.EBI Wyeth-Ayerst Research
2498517 31 Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors.EBI Pfizer Inc.
2496229 34 Synthesis and in vitro aldose reductase inhibitory activity of compounds containing an N-acylglycine moiety.EBI Auburn University
2120443 1 (Pyrimidinyloxy)acetic acids and pyrimidineacetic acids as a novel class of aldose reductase inhibitors.EBI Wyeth-Ayerst Research
1956050 18 Gossypol and derivatives: a new class of aldose reductase inhibitors.EBI University of New Mexico School of Medicine
1908522 5 Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.EBI Wyeth-Ayerst Research
1906108 27 Relative structure-inhibition analyses of the N-benzoyl and N-(phenylsulfonyl) amino acid aldose reductase inhibitors.EBI Auburn University
1901912 1 Quinazolineacetic acids and related analogues as aldose reductase inhibitors.EBI Wyeth-Ayerst Research
1899452 90 Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners.EBI Pfizer Inc.
1738141 63 Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain.EBI Pfizer Inc
1613743 27 Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives.EBI Pfizer Inc
1597858 56 Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors.EBI Tanabe Seiyaku Co., Ltd.
1552504 8 Selective irreversible inhibitors of aldose reductase.EBI Ohio State University
27359042 29 IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 InhibitorsBDB Institut de Ge´ne´tique et de Biologie Mole´culaire et Cellulaire
27544072 29 Coumarin-thiazole and -oxadiazole derivatives: Synthesis, bioactivity and docking studies for aldose/aldehyde reductase inhibitors.BDB COMSATS Institute of Information Technology
24607578 11 Development of novel pyrazolone derivatives as inhibitors of aldose reductase: an eco-friendly one-pot synthesis, experimental screening and in silico analysis.BDB Swami Ramanand Teerth Marathwada University, Nanded (MS), India
23988122 7 Modulation of aldose reductase inhibition by halogen bond tuning.BDB Academy of Sciences of the Czech Republic
16190759 60 A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.BDB Pfizer
15857120 81 Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.BDB The Institute for Diabetes Discovery
12773033 17 A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.BDB Pfizer
17083960 39 Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.BDB Medical College of Wiscosin
17418233 9 Evidence for a novel binding site conformer of aldose reductase in ligand-bound state.BDB University of Marburg
17368668 8 Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution.BDB University of Marburg