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59 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25890697 6 Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions.EBI Punjabi University
25695864 35 Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold.EBI Slovak Academy of Sciences
25375908 9 Targeting aldose reductase for the treatment of diabetes complications and inflammatory diseases: new insights and future directions.EBI Universit£ degli Studi di Messina
25152999 9 20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng.EBI Kyushu University
24071447 39 Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10.EBI Gifu Pharmaceutical University
23683835 21 Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors.EBI Xiangtan University
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
21561086 21 Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.EBI Gifu Pharmaceutical University
22263837 262 Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17ß-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.EBI University of Pennsylvania
18492610 9 Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives.EBI Universit£ di Messina
18165015 18 Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.EBI Monash University
18087047 3 Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.EBI Universitat Aut£noma de Barcelona
12540241 5 Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.EBI Aristotle University of Thessaloniki
10737739 11 Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants.EBI National Eye Institute
8027986 30 Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.EBI Wyeth-Ayerst Research
1613744 68 Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.EBI Pfizer Inc.
1900532 44 A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.EBI Pfizer Inc.
2113948 11 Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones.EBI Pfizer Central Research
3121857 116 Spiro hydantoin aldose reductase inhibitors.EBI Pfizer Central Research
22104435 54 Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-ß-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1.EBI University of Toyama
22261024 21 Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase.EBI King's College London
22236472 51 Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10.EBI Gifu Pharmaceutical University
22047696 17 Structure-activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors.EBI Sepuluh Nopember Institute of Technology
22037047 1 (2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature.EBI Slovak Academy of Sciences
21944852 79 Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.EBI AstraZeneca R&D Charnwood
21916510 167 Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.EBI Merck Serono S.A.
19250825 4 Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.EBI The Institute for Diabetes Discovery, LLC
21256748 8 Furoxan nitric oxide donor coupled chrysin derivatives: synthesis and vasculoprotection.EBI Central South University
21129963 23 In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.EBI University of Messina
20805028 32 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2.EBI University of Toyama
20304656 31 Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10.EBI Gifu Pharmaceutical University
20071057 4 Evaluation of aldose reductase inhibition and docking studies of 6'-nitro and 6',6''-dinitrorosmarinic acids.EBI National Hellenic Research Foundation
20189816 8 Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole.EBI Aristotle University of Thessaloniki
18976928 1 Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols.EBI Central Food Technological Research Institute
17870536 28 Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.EBI Università di Modena e Reggio Emilia
16107153 10 Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.EBI Monash University (Parkville Campus)
15317464 4 High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor.EBI Monash University (Parkville Campus)
14613323 10 Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product.EBI Instituto Biomar, S.A.
10882376 7 A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.EBI Rational Drug Design Laboratories
6779009 1 Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids.EBI TBA
3934383 6 Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil.EBI TBA
3925146 43 Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.EBI TBA
3097317 19 Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids.EBI TBA
2498517 31 Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors.EBI Pfizer Inc.
1956050 18 Gossypol and derivatives: a new class of aldose reductase inhibitors.EBI University of New Mexico School of Medicine
1899452 90 Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners.EBI Pfizer Inc.
1738141 63 Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain.EBI Pfizer Inc
1613743 27 Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives.EBI Pfizer Inc
1597858 56 Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors.EBI Tanabe Seiyaku Co., Ltd.
27359042 29 IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 InhibitorsBDB Institut de Ge´ne´tique et de Biologie Mole´culaire et Cellulaire
24607578 11 Development of novel pyrazolone derivatives as inhibitors of aldose reductase: an eco-friendly one-pot synthesis, experimental screening and in silico analysis.BDB Swami Ramanand Teerth Marathwada University, Nanded (MS), India
23988122 7 Modulation of aldose reductase inhibition by halogen bond tuning.BDB Academy of Sciences of the Czech Republic
16190759 60 A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.BDB Pfizer
15857120 81 Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.BDB The Institute for Diabetes Discovery
12773033 17 A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.BDB Pfizer
17083960 39 Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.BDB Medical College of Wiscosin
17418233 9 Evidence for a novel binding site conformer of aldose reductase in ligand-bound state.BDB University of Marburg
17368668 8 Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution.BDB University of Marburg