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46 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26403853 32 Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.EBI Roche Pharma Research and Early Development (pRED)
26288685 59 Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.EBI Merck Research Laboratories
26005536 92 Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.EBI Merck Research Laboratories
25874338 90 Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11-Hydroxylase.EBI Saarland University
25711516 118 Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability.EBI Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
25528333 32 Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.EBI Saarland University
24422519 31 Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases.EBI Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
25462268 44 1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: a new class of potent and selective aldosterone synthase inhibitors.EBI Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
25462231 85 Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11-hydroxylase.EBI Universit£ degli Studi di Bari"Aldo Moro"
25176013 70 Potent 11-hydroxylase inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote wound healing.EBI Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
24899257 71 Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors.EBI Saarland University
23992859 2 Emerging technologies for metabolite generation and structural diversification.EBI AbbVie Bioresearch Center
23869452 67 Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type.EBI Saarland University
23859149 76 Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.EBI Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
23363058 68 Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition.EBI University of Bologna
24900679 32 Aldosterone synthase inhibitors.EBI Temple University
23281812 95 Tetrahydropyrroloquinolinone type dual inhibitors of aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks.EBI Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
22861193 60 Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer.EBI Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
22788843 46 Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome.EBI Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
20550118 69 Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors.EBI Saarland University
21384875 67 Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.EBI Saarland University
21341743 42 Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-a-hydroxylase/C17-20 lyase.EBI Universita` degli Studi di Bari Aldo Moro
21129965 18 N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).EBI Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland
20684610 73 Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.EBI Saarland University
20615692 52 The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.EBI Novartis Institutes for BioMedical Research
20121113 94 Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).EBI Eindhoven University of Technology
19049427 98 In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.EBI Saarland University
18763754 57 Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.EBI Saarland University
18672861 91 Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.EBI Saarland University
8632407 43 Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17.EBI Universität de Saarlandes
7783141 28 Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom.EBI Universität des Saarlandes
2016706 29 Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones.EBI CIBA-GEIGY AG.
18672868 76 Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer.BDB Saarland University
16246562 4 Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2).BDB Saarland University
16220979 64 Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.BDB Saarland University
16570918 49 Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.BDB Saarland University
15771425 65 Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase.BDB Saarland University
15743198 134 Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.BDB Saarland University