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46 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25461326 20 Conformationally-locked N-glycosides: exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease.EBI Universitat Rovira i Virgili
25250725 295 Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.EBI Leiden University
24803362 12 Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy.EBI Technical University Graz
24657053 8 Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.EBI University of Toyama
23880081 8 Rapid modifications of N-substitution in iminosugars: development of new▀-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease.EBI Genomics Research Center
19397268 21 Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.EBI Peking University
23106358 96 a-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based orala-glucosidase inhibitor for improving postprandial hyperglycemia.EBI University of Toyama
22646221 11 Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.EBI National Center for Advancing Translation Sciences
22762530 2 Conformationally-locked N-glycosides with selectiveß-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease.EBI Universitat Rovira i Virgili
22512696 61 Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease.EBI Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC)
22360565 20 Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease.EBI University of British Columbia
20557054 56 Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease.EBI Universitat de Barcelona
18595718 51 In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.EBI Hokuriku University
10843222 17 Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton.EBI University of Tokyo
10098675 6 Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors.EBI Technische Universit£t Berlin
9871687 6 A new strong inhibitor of beta-mannosidase.EBI S.E.S.N.A.B., Pole Sciences et Technologie, Universit� de La Rochelle. therisod@icmo.u-psud.fr
21862336 9 Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes.EBI University of Reading
21546253 41 Docking and SAR studies of D- and L-isofagomine isomers as humanß-glucocerebrosidase inhibitors.EBI University of Toyama
21370884 80 New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening.EBI Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas)
21292481 4 Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease.EBI Aarhus University
17187079 1 Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.EBI Harvard Medical School
20231099 9 Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors.EBI Universit£ d'Orl£ans& CNRS
19931460 6 Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.EBI Utrecht University
15165148 13 Glycosidase-inhibiting pyrrolidines and pyrrolizidines with a long side chain in Scilla peruviana.EBI Hokuriku University
11392550 5 Powerful probes for glycosidases: novel, fluorescently tagged glycosidase inhibitors.EBI Institut für Biochemie der Technischen Universität Graz
11327590 7 Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors.EBI Technische Universität Graz
23775891 83 New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease.BDB Nankai University
21751327 10 Synthesis, kinetic evaluation and cell-based analysis of C-alkylated isofagomines as chaperones of ╬▓-glucocerebrosidase.BDB University of British Columbia
18972510 6 Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.BDB Research Institute, Hospital for Sick Children
21079602 5 Ultrasensitive in situ visualization of active glucocerebrosidase molecules.BDB Leiden University
17827006 36 N(4)-Phenyl modifications of N(2)-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease.BDB NIH
17670938 23 Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.BDB NIH
17201413 5 Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention.BDB The Scripps Research Institute
16919960 27 Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease.BDB Hokuriku University