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74 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28337326 3 Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.EBI National Center for Scientific Research Demokritos
28089350 8 Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.EBI Northern Illinois University
27390066 99 Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues.EBI Wroclaw University of Technology
27100031 85 A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases.EBI Wroclaw University of Technology
26629857 44 Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation.EBI Fudan University
26463133 22 Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide.EBI Institute of Advanced Chemistry of Catalonia (IQAC-CSIC)
26241877 7 Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route.EBI Pharmaleads
25982416 43 Exploring S1 plasticity and probing S1' subsite of mammalian aminopeptidase N/CD13 with highly potent and selective aminobenzosuberone inhibitors.EBI Universit£ de Haute Alsace
25635706 171 3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties.EBI National Center for Scientific Research"Demokritos"
25192493 57 Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.EBI University of Athens
24927250 18 New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment.EBI Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France.
23916253 22 Novel selective inhibitors of aminopeptidases that generate antigenic peptides.EBI University of California San Diego
23860593 17 Novel▀-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN).EBI Shandong University
23664876 1 Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor.EBI The University of Oklahoma Health Sciences Center
23528299 4 Discovery of a synthetic Aminopeptidase N inhibitor LB-4b as a potential anticancer agent.EBI Shandong University
23582273 12 Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors.EBI Nanjing University
23634668 97 Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.EBI Johns Hopkins University School of Medicine
23510562 30 Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN).EBI Shandong University
23428964 9 Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy.EBI Universit£ de Haute-Alsace
23453219 29 Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).EBI Shandong University
20691509 47 QSAR study of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2 using LS-SVM and GRNN based on principal components.EBI Kermanshah University of Medical Sciences
19757839 26 The replacement of His(4) in angiotensin IV by conformationally constrained residues provides highly potent and selective analogues.EBI Vrije Universiteit Brussel
24900417 59 Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis.EBI TBA
22796349 34 Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors.EBI Universit£ de Haute Alsace
21780776 40 Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry.EBI Wroclaw University of Technology
22607877 38 Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors.EBI Shandong University
24900367 16 Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor.EBI TBA
22224710 44 Structure-activity relationship study of opiorphin, a human dual ectopeptidase inhibitor with antinociceptive properties.EBI Institute of Advanced Chemistry of Catalonia (IQAC-CSIC)
20621724 50 Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors.EBI Universit£t Heidelberg
19822427 21 Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity.EBI Loyola University
19209899 9 A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products.EBI University of California Santa Cruz
17331715 19 Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors.EBI Korea Research Institute of Chemical Technology
15582436 7 N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity.EBI Sejong University
11585456 8 Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.EBI INSERM
7909847 33 Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors.EBI INSERM
14684305 11 Investigation of novel fumagillin analogues as angiogenesis inhibitors.EBI Gilead Sciences
12873488 11 Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors.EBI Universit£ de Lille 2
10098663 81 Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs.EBI University of Tokyo
 40 Pseudopeptide inhibitors of aminopeptidases containing the [CH(CN)NH] surrogate as a transition-state MIMICEBI TBA
21925884 16 Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors.EBI Nanjing University
21911297 40 Design, synthesis and biological evaluation of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as aminopeptidase N/CD13 inhibitors.EBI Shan Dong University
21802307 64 Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine.EBI Shandong University
21476495 31 Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis.EBI Uppsala University
21306895 46 Discovery ofß-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors.EBI Korea Research Institute of Chemical Technology
21292493 23 Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13.EBI Laboratoire de Chimie Organique et Bioorganique, FRE3252, ENSCMu, F-68093 Mulhouse Cedex, France.
21047126 51 Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP).EBI Uppsala University
20129718 32 Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Structure-based design, chemistry and activity evaluation. II.EBI Shandong University
20347318 49 New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13.EBI Wroclaw University of Technology
18718763 50 Synthesis of new sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.EBI Shandong University
18556208 48 Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2.EBI Uppsala University
18457385 41 Recent developments in fragment-based drug discovery.EBI Astex Therapeutics Ltd.
18440232 38 Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.EBI Shandong University
18362041 59 Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors.EBI Shandong University
17270439 23 Novel hydroxamic acid-related phosphinates: inhibition of neutral aminopeptidase N (APN).EBI Wroclaw University of Technology
16970390 6 Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo.EBI The Johns Hopkins University School of Medicine
15149671 22 Design and synthesis of beta-amino-alpha-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth.EBI Celera
15012983 169 3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.EBI Abbott Laboratories
14684302 8 Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors.EBI The Ohio State University
12877582 3 Fumagalone, a reversible inhibitor of type 2 methionine aminopeptidase and angiogenesis.EBI Johns Hopkins University School of Medicine
10090787 25 Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors.EBI University of Antwerp (UIA)
1738140 26 alpha-Keto amide inhibitors of aminopeptidases.EBI University of Wisconsin-Madison
26686773 24 Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.BDB German Cancer Research Center (DKFZ)
17656313 14 Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.BDB The Johns Hopkins University
9224570 23 Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.BDB Massachusetts Institute of Technology
17114291 10 Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.BDB Johns Hopkins University
17350258 27 Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids.BDB Abbott Laboratories
16632353 14 Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties.BDB Abbott Laboratories
14633714 18 Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2.BDB Abbott Laboratories
16789740 109 Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.BDB Abbott Laboratories
16134930 30 4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.BDB GSK
17636946 94 Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.BDB GSK