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275 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27933960 122 Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.EBI National Institute on Drug Abuse
27080180 39 Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.EBI University of Arkansas for Medical Sciences
26935940 23 Emerging targets and new small molecule therapies in Parkinson's disease treatment.EBI School of Medicine of University of Electronic Science and Technology of China
26748694 44 The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.EBI Gedeon Richter Plc
26233799 15 Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine.EBI Virginia Commonwealth University
25593099 57 Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template.EBI Wayne State University
25461308 64 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. Part 4.EBI Medical University of Warsaw
25193229 102 Alpha-ethyltryptamines as dual dopamine-serotonin releasers.EBI Research Triangle Institute
24944732 37 Hybrid dopamine uptake blocker-serotonin releaser ligands: a new twist on transporter-focused therapeutics.EBI RTI International
24942641 7 Molecular basis of the selective binding of MDMA enantiomers to the alpha4beta2 nicotinic receptor subtype: synthesis, pharmacological evaluation and mechanistic studies.EBI University of Barcelona
24717153 46 Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors.EBI Gedeon Richter Plc
722762 2 Effects of thiophene analogues of chloroamphetamines on central serotonergic mechanisms.EBI TBA
23394318 1 Antidepressant abietane diterpenoids from Chinese eaglewood.EBI Chinese Academy of Medical Sciences and Peking Union Medical College
23279866 69 Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors.EBI Jagiellonian University Medical College
12372532 45 Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives.EBI UCB Pharma SA
18829312 64 Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity.EBI GlaxoSmithKline
18433113 124 Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.EBI GlaxoSmithKline
15261283 4 Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential.EBI Institute for Biological Research
11755367 38 First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants.EBI UCB Pharma SA
21486038 177 Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.EBI H. Lundbeck A/S
23022052 6 A novel spirocyclic tropanyl-¿²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake.EBI Universit£ degli Studi di Milano
22749190 23 Wake-promoting agents: search for next generation modafinil: part IV.EBI Cephalon (France)
21344069 43 Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues.EBI National Institute on Drug Abuse - Intramural Research Program
20724153 31 Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.EBI Korea Institute of Science and Technology
20036131 68 Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.EBI University of Kentucky
19896846 44 Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes.EBI University of New Orleans
18954038 62 Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain.EBI Neurocrine Biosciences, Inc.
18774292 72 Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol.EBI National Institute on Drug Abuse-Intramural Research Program
19038547 62 1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors.EBI The State University of New York
18834188 232 Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2.EBI Wyeth Research
18539031 126 Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.EBI Neurocrine Biosciences, Inc.
18249549 54 Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters.EBI Wayne State University
18278854 20 Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity.EBI The University of Mississippi
18060777 158 Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.EBI Johnson& Johnson Pharmaceutical Research& Development L.L.C.
17228858 236 Advances in development of dopaminergic aporphinoids.EBI Chinese Academy of Sciences
17489581 95 Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.EBI School of Chemistry and Biochemistry
17267226 46 Novel piperazines: potent melanocortin-4 receptor antagonists with anxiolytic-like activity.EBI Taisho Pharmaceutical Co., Ltd
17034144 72 Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation.EBI National Institute on Drug Abuse-Intramural Research Program
16854086 96 Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.EBI Wyeth Research
16821765 29 Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction.EBI Chinese Academy of Sciences
15857139 31 Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter.EBI Universit£ di Ferrara
15801844 25 Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.EBI Universidad Complutense
15743177 43 Synthesis and biological evaluation of meperidine analogues at monoamine transporters.EBI University of New Orleans
15916437 90 Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds.EBI Research Triangle Institute
15537337 95 Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization.EBI Acenta Discovery, Inc.
15456254 60 Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters.EBI Wayne State University
15686927 39 Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency.EBI Yale University
15163183 92 Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring.EBI University of Illinois at Chicago
15027858 35 Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives.EBI University of New Orleans
14711303 115 Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.EBI Research Triangle Institute
15189035 67 Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation.EBI National Institute on Drug Abuse--Intramural Research Program
12672245 54 Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors.EBI School of Chemistry and Biochemistry
12646032 30 High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo.EBI Wayne State University
14640559 405 Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.EBI FAES FARMA S A
12825932 61 Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter.EBI National Institute on Drug Abuse
12801223 71 Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.EBI NIDA-IRP
12747792 12 Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine.EBI Wayne State University
12723962 69 Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites.EBI Georgetown University Medical Center
12723940 145 2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.EBI Research Triangle Institute
11960503 140 Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors.EBI Georgetown University Medical Center
11806716 44 Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.EBI Wayne State University
12190324 15 Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter.EBI Research Triangle Institute
12109901 45 SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement.EBI Georgetown University Medical Center
11300876 47 Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.EBI Wayne State University
11170654 72 Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes.EBI National Institute on Drug Abuse-Intramural Research Program
11689080 43 Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11334571 79 Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors.EBI Georgetown University Medical Center
10737754 30 Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors.EBI Georgetown University Medical Center
11123996 21 Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11123994 72 Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909).EBI National Institute of Diabetes and Digestive and Kidney Diseases
10821718 69 Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter.EBI Georgetown University Medical Center
10229626 66 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.EBI Universit£ di Siena
10579846 68 Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-substituted-6-amino-5-phenylbicyclo[2.2.2]octanes.EBI School of Chemistry and Biochemistry
10543888 60 Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.EBI National Institute on Drug Abuse-Intramural Research Program
9513601 53 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.EBI Universit£ di Siena
9836615 106 Synthesis and biological properties of new 2beta-alkyl- and 2beta-aryl-3-(substituted phenyl)tropane derivatives: stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters.EBI Georgetown University Medical Center
9804688 51 Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes.EBI University of Minnesota
9457247 39 Synthesis and ligand binding of tropane ring analogues of paroxetine.EBI Research Triangle Institute
9632371 28 2beta-Substituted analogues of 4'-iodococaine: synthesis and dopamine transporter binding potencies.EBI University of Oklahoma Health Sciences Center
9135033 36 Synthesis and ligand binding of nortropane derivatives: N-substituted 2beta-carbomethoxy-3beta-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-disubstituted phenyl)nortropane. New high-affinity and selective compounds for the dopamine transporter.EBI INSERM
9111298 18 Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.EBI Research Triangle Institute
9397165 27 3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter.EBI Research Triangle Institute
8941383 146 Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).EBI National Institute of Diabetes and Digestive and Kidney Diseases
8863789 31 3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.EBI Research Triangle Institute
8831768 65 Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.EBI Research Triangle Institute
8558525 60 N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain.EBI Research Biochemicals International
8709106 89 Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position.EBI Research Triangle Institute
7830281 237 Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter.EBI Research Triangle Institute
7658431 18 Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes.EBI Research Triangle Institute
7629808 64 Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.EBI Universit£ di Siena
8176704 40 Synthesis of 2 beta-acyl-3 beta-aryl-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex.EBI Wake Forest University
8164265 42 Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.EBI National Institute on Drug Abuse
8411004 42 3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters.EBI Research Triangle Institute
1619622 51 Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.EBI Research Triangle Institute
1920365 8 [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain.EBI Research Biochemicals Inc.
1976813 80 2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity.EBI Wyeth-Ayerst Research
2903929 66 Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.EBI H. Lundbeck A/S
3039136 259 Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.EBI TBA
4032430 4 Molecular mechanism of action of 5,6-dihydroxytryptamine. Synthesis and biological evaluation of 4-methyl-, 7-methyl-, and 4,7-dimethyl-5,6-dihydroxytryptamines.EBI TBA
2999402 192 3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake.EBI TBA
6747993 66 Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin.EBI TBA
6492080 192 Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins.EBI TBA
6134833 36 Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.EBI TBA
7452682 76 3-(4-Piperidinylalkyl)indoles, selective inhibitors of neuronal 5-hydroxytryptamine uptake.EBI TBA
15115403 48 Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.EBI National Institute of Diabetes and Digestive and Kidney Diseases
15149693 56 The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor.EBI National Institute on Drug Abuse--Intramural Research Program
15109634 129 SAR development of a selective 5-HT1D antagonist/serotonin reuptake inhibitor lead using rapid parallel synthesis.EBI Eli Lilly and Co. Ltd
12699762 27 Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter.EBI Wayne State University
14505672 78 Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors.EBI Georgetown University Medical Center
11909701 35 Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors.EBI Georgetown University Medical Center
11859009 16 Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.EBI Inha University
12127543 26 Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines.EBI Southern Research Institute
12067559 34 Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol.EBI University of Michigan
11354356 42 Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors.EBI Georgetown University Medical Center
11277529 14 Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter.EBI Universit£ di Ferrara
11720867 24 [3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.EBI National Institute on Drug Abuse - Intramural Research Program
11527726 15 Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter.EBI Wayne State University
11514143 71 Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles.EBI Georgetown University Medical Center
11078197 65 3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter.EBI Research Triangle Institute
10937724 56 Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors.EBI Georgetown University Medical Center
10915050 14 Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1.EBI Inha University
10888328 17 An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes.EBI Georgetown University Medical Center
10612593 33 N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter.EBI Georgetown University Medical Center
10576696 32 Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands.EBI Merck
9871604 114 Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group.EBI Hong Kong University of Science and Technology
9934496 27 Synthesis and transporter binding properties of (R)-2 beta, 3 beta- and (R)-2 alpha, 3 alpha-diaryltropanes.EBI Research Triangle Institute
 28 Synthesis and evaluation of novel-N-[2-(bis-aryl-methoxy)ethyl-N-aralkyl-,-alkanediamines as potent and selective dopamine reuptake inhibitors: Seco analogs of GBR12935 and GBR12909EBI TBA
22341942 18 Wake-promoting agents: search for next generation modafinil: part II.EBI Cephalon, Inc.
22264475 10 Wake-promoting agents: search for next generation modafinil: part I.EBI Cephalon, Inc.
22309909 37 Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.EBI National Medicines Institute
22055716 45 Further structure-activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters.EBI University of New Orleans
21469694 4 Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action.EBI University of Navarra
21446715 43 Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents.EBI Wayne State University
21093118 32 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. part 3.EBI Medical University of Warsaw
21093273 154 Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.EBI Sepracor Inc.
20980153 83 Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.EBI University of New Orleans
20672825 67 Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters.EBI National Institute on Drug Abuse-Intramural Research Program
19717215 56 Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.EBI Trinity College
20022503 15 Synthesis and antidepressant activity of optical isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl) propan-1-ol (SIPI5056).EBI Institute of Pharmaceutical Industry
20064720 44 Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity.EBI Wyeth Research
19665823 38 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2.EBI Medical University of Warsaw
19640707 12 Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.EBI University of Glasgow
19719241 55 Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.EBI Wyeth Research
 49 Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.EBI TBA
 18 N-Phthalimidoalkyl derivatives of 2β-carbomethoxy-3β-(4′-iodophenyl)tropane (β-CIT): Brain monoamine transporter affinityEBI TBA
 34 Bivalent indoles exhibiting serotonergic binding affinityEBI TBA
18995929 24 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, part 1.EBI Medical University of Warsaw
18793858 27 Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging.EBI INSERM
18762424 4 New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.EBI University of Glasgow
18571421 78 Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.EBI Wyeth Research
18557608 108 Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.EBI Wyeth Research
17698848 4 Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.EBI Yale University
17765543 56 Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores.EBI Johnson & Johnson Pharmaceutical Research and Development L.L.C.
17658253 23 New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET.EBI Institut für Interdisziplinäre Isotopenforschung
17616397 107 Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.EBI Johnson & Johnson Pharmaceutical Research & Development LLC
17583504 51 Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors.EBI Johnson & Johnson Pharmaceutical Research & Development L.L.C.
17412583 81 Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity.EBI Johnson & Johnson Pharmaceutical Research & Development
17407811 34 Novel pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and 5-HT1A receptor.EBI Wyeth Research
17376695 7 Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines.EBI Inha University
17350257 54 Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters.EBI University of Oslo
17328523 36 Novel sigma receptor ligands: synthesis and biological profile.EBI University of Catania
17317177 69 Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.EBI Johnson & Johnson Pharmaceutical Research and Development L.L.C.
17307358 81 Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.EBI Johnson & Johnson Pharmaceutical Research & Development L.L.C.
17234422 118 Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor.EBI Taisho Pharmaceutical Co., Ltd
17127069 96 DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods.EBI University Heights
17127059 96 Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.EBI Johnson & Johnson Pharmaceutical Research and Development L.L.C.
17107798 90 Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.EBI Johnson & Johnson Pharmaceutical Research and Development LLC
17095215 25 Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.EBI Institute for Degenerative Diseases
17064081 10 Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane.EBI National Institute on Drug Abuse-Intramural Research Program
16908151 24 Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(4'-p-substituted phenyl)-piperidine analogs of cocaine.EBI Yale University
16905316 42 Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.EBI University of Kentucky
16821783 60 Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and noEBI Wayne State University
16753296 25 Discovery of potent CRTh2 (DP2) receptor antagonists.EBI AstraZeneca R&D Charnwood
16335921 99 Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors.EBI University of Illinois at Chicago
16332439 58 Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.EBI Wyeth Research
16250644 66 Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyl]piperazines, novel potential antipsychotics combining potent dopamine D2 receptor antagonism with potent serotonin reuptake inhibition.EBI Solvay Pharma
16236497 48 Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes.EBI Yale University
16033275 7 Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.EBI Wayne State University
16033253 27 Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.EBI Schering-Plough Research Institute
15863297 57 Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants.EBI Acenta Discovery, Inc.
15686885 28 Studies towards the next generation of antidepressants. Part 4: derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor.EBI Wyeth Research
15482938 45 Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents.EBI Harvard Medical School
15454211 19 Novel aryloxy-8-azabicyclo[3.2.1]oct-3-enes with 5-HT transporter and 5-HT1A affinity.EBI Wyeth Research
15341484 159 Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.EBI Merck KGaA
15239661 120 Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.EBI Wyeth Research
15080991 38 Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT).EBI Yale School of Medicine
15026075 51 Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites.EBI State University of New York
14592479 60 Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3.EBI Lilly Research Laboratories
12873501 110 Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.EBI Johnson & Johnson Pharmaceutical Research & Development
12824042 64 Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT(1A) receptor antagonism/SSRI activities. Part 2.EBI Lilly Research Laboratories
12749894 48 Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1.EBI Lilly Research Laboratories
12672246 68 Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.EBI NIDDK
12668005 21 Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.EBI Universidad Complutense
12657288 102 Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter.EBI NIDDK
12639545 37 Synthesis of dopamine transporter selective 3-[2-(diarylmethoxyethylidene)]-8-alkylaryl-8-azabicyclo[3.2.1]octanes.EBI University of New Orleans
12565970 44 Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents.EBI National Institute of Diabetes and Digestive and Kidney Diseases
12565939 38 SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition.EBI Solvay Pharma
12482441 45 Development of a presynaptic 5-HT1A antagonist.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
12443787 2 Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter.EBI Institutet
12361398 19 New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).EBI University of Pennsylvania
12213056 42 Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors.EBI Universidad de Navarra
12109911 47 Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.EBI University Center for Pharmacy
11965364 36 Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter.EBI National Institute on Drug Abuse-Intramural Research Program
11958976 30 Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters.EBI State University of New York
11882001 34 Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11881994 42 Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.EBI INSERM
11814784 53 Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.EBI Wyeth-Ayerst Research Laboratories
11714608 30 Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter.EBI Alcohol and Drug Abuse Research Center
11462981 184 New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.EBI Universidad de Navarra
11459653 31 Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.EBI Wyeth-Ayerst Research Laboratories
11334561 63 Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites.EBI State University of New York
11229754 28 Synthesis and monoamine transporter affinity of 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicycl.EBI State University of New York
11133081 33 A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents.EBI Georgetown University Medical Center
11128642 5 Serotonin transporter inhibitors: synthesis and binding potency of 2'-methyl- and 3'-methyl-6-nitroquipazine.EBI Central Washington University
10969967 34 Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(2''-, 3''- or 4''-substituted) biphenyltropanes.EBI Yale University
10782691 1 Novel 3-(4-piperidinylthio)-1H-indoles as potent nonopioid orally active central analgesics.EBI Laboratoires UPSA
10669562 29 Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies.EBI Georgetown University Medical Center
10612583 27 Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine.EBI University of New Orleans
10585212 138 Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.EBI National Institute of Diabetes and Digestive and Kidney Diseases
9719604 11 Synthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker.EBI Hokkaido University
9703474 21 Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.EBI Organix Inc.
9526575 14 Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA).EBI Purdue University
9513598 20 Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues.EBI Organix Inc.
9435902 60 Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.EBI National Institute on Drug Abuse
9397171 81 N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.EBI University of Minnesota
9357518 74 Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.EBI University of Strathclyde
9089327 58 Structure-activity studies for a novel series of N-(arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamine s possessing dual 5-HT uptake inhibiting and alpha2-antagonistic activities.EBI Abbott Park
9057857 169 Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.EBI National Institute of Diabetes and Digestive and Kidney Diseases
9016326 38 Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity.EBI Organix Inc.
9016323 2 Synthesis and characterization of technetium-99m-labeled tropanes as dopamine transporter-imaging agents.EBI University of Pennsylvania
8960553 60 Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter.EBI Drew University
8941398 17 Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.EBI Hokkaido University
8691453 42 Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site.EBI State University of New York
8576918 38 Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: synthesis and biological evaluation at the dopamine and serotonin transporter sites.EBI Organix Inc.
8515426 12 Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.EBI University of Toledo
8487257 57 New indole derivatives as potent and selective serotonin uptake inhibitors.EBI Centre de Recherches de Vitry-Alfortville
6716399 2 Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines.EBI TBA
6458703 72 Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake.EBI TBA
3735309 30 Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2,3-dihydroindoles.EBI TBA
1967651 2 Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).EBI Purdue University
23574807 12 Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors.BDB University of Troms£
18387300 90 Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.BDB Pfizer Global Research and Development
15356216 48 Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential.BDB Farmaceutiche e Farmacologiche
12761331 97 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.BDB Case Western Reserve University
12649362 8 Mixed cocaine agonist/antagonist properties of (+)-methyl 4beta-(4-chlorophenyl)-1-methylpiperidine-3alpha-carboxylate, a piperidine-based analog of cocaine.BDB Georgetown University
12023542 23 Effects of norepinephrine and serotonin transporter inhibitors on hyperactivity induced by neonatal 6-hydroxydopamine lesioning in rats.BDB Harvard University
11961053 26 Biochemical and behavioral characterization of novel methylphenidate analogs.BDB Mercer University
11750180 139 Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.BDB Lilly Research Laboratories
11714872 14 The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine(1A) receptor agonist.BDB AstraZeneca R&D
11454918 90 S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.BDB Institut de Recherches Servier
11071707 71 Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.BDB NIH
10379421 134 Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.BDB TBA
10340630 3 Venlafaxine: discrepancy between in vivo 5-HT and NE reuptake blockade and affinity for reuptake sites.BDB McGill University
10336510 53 Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs.BDB Virginia Commonwealth University
9669506 12 Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters.BDB McGill University
9400006 184 Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.BDB Emory University
9223589 17 N-(3-lodoprop-2E-enyl)-2beta-carbomethoxy-3beta-(3',4'-dichloro phenyl)nortropane (beta-CDIT), a tropane derivative: pharmacological characterization as a specific ligand for the dopamine transporter in the rodent brain.BDB INSERM U316
8996185 121 Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.BDB Synthélabo Recherche
8876023 52 Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor.BDB University of Turku
8424846 7 LY248686, a new inhibitor of serotonin and norepinephrine uptake.BDB Eli Lilly and Company
8413837 45 [3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments.BDB Boots Pharmaceuticals
7562497 127 Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception.BDB R.W. Johnson Pharmaceutical Research Institute
6310078 55 Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.BDB Pfizer Inc.,
6123593 24 A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain.BDB Eli Lilly and Company
3790168 23 Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative.BDB Wyeth Laboratories, Inc.
3419539 56 Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers.BDB Organon International
2970277 11 Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimipramine.BDB Veterans Administration Medical Center
2905001 64 McN-5652: a highly potent inhibitor of serotonin uptake.BDB McNeil Pharmaceutical
2580950 69 Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin.BDB Lundbeck AIS
2530094 94 The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.BDB Novo Industri A/S
1661335 95 Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins.BDB Center for Bio-Pharmaceutical Sciences
18812261 8 The molecular interactions of buspirone analogues with the serotonin transporter.BDB National Medicines Institute
17602602 117 Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes.BDB Research Triangle Institute
18393401 70 Design and Synthesis of 2- and 3-Substituted-3-phenylpropyl Analogs of 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: Role of Amino, Fluoro, Hydroxyl, Methoxyl, Methyl, Methylene, and Oxo Substituents on Affinity fBDB National Taiwan University