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138 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27989417 34 1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability.EBI University of M£nster
27309570 102 Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.EBI Alma Mater Studiorum University of Bologna
27189675 38 The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors.EBI Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
27130358 67 Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.EBI E.I. Du Pont de Nemours and Company
27117424 7 Design, synthesis and biological evaluation of potent FAAH inhibitors.EBI Univ. Lille
26888301 34 Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.EBI University of Siena
26774927 120 Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.EBI Fondazione Istituto Italiano di Tecnologia
26850005 89 Arylboronic acids as dual-action FAAH and TRPV1 ligands.EBI Sapienza Universit£ di Roma
26344596 66 Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors.EBI University of Eastern Finland
25282655 51 Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).EBI University of Eastern Finland
26002335 55 Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH).EBI Universit£ di Ferrara
25752982 26 Loratadine analogues as MAGL inhibitors.EBI University of Eastern Finland
25701254 48 Novel tail and head group prostamide probes.EBI Northeastern University
25065940 77 Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.EBI Universit£ degli Studi di Siena
25037918 33 Discovery libraries targeting the major enzyme classes: the serine hydrolases.EBI The Scripps Research Institute
24972328 26 Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii.EBI University of Szeged
25467164 20 Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.EBI Roseman University of Health Sciences
24944750 24 Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.EBI Merck Research Laboratories
24690529 43 a-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.EBI The Scripps Research Institute
24456116 105 Design, synthesis, and characterization ofa-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase.EBI The Scripps Research Institute
24513048 88 1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.EBI Janssen Pharmaceutical Companies of Johnson& Johnson
24508127 19 Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.EBI Universit£ Lille Nord de France
24440478 22 Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.EBI Takeda Pharmaceutical Company Ltd
24433863 76 Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase.EBI Janssen Research and Development, L.L.C.
24083878 61 Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.EBI University of Eastern Finland
23891163 30 Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition.EBI MCPHS University
23822179 17 Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.EBI Fondazione Istituto Italiano di Tecnologia
23712084 2 Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase.EBI Centre for Addiction and Mental Health
23474898 161 Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.EBI Sapienza Universit£ di Roma
23455058 84 (4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).EBI University of M£nster
23237837 14 Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.EBI Universit£ degli Studi di Siena
23218778 49 Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.EBI Takeda Pharmaceutical Company Ltd
23287055 20 An unprecedented reversible mode of action ofß-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH).EBI Universit£ catholique de Louvain
23214511 4 Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.EBI Centre for Addiction and Mental Health
23206861 113 Tetrahydro-ß-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.EBI Sapienza Universit£ di Roma
21820769 20 Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability.EBI Universit£ degli Studi di Parma
20570023 16 Chemistry around imidazopyrazine and ibuprofen: discovery of novel fatty acid amide hydrolase (FAAH) inhibitors.EBI Universit£ catholique de Louvain
19883085 86 Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.EBI Universite Catholique de Louvain
19719235 19 Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain.EBI Ghent University
16392827 56 Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates.EBI Universit£ catholique de Louvain
15482935 1 Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice.EBI Kyushu University
23141911 60 Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.EBI Janssen Research and Development, LLC
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
23116186 68 Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).EBI AstraZeneca
23043222 125 Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.EBI Istituto Italiano di Tecnologia
22738638 59 Assay and inhibition of diacylglycerol lipase activity.EBI Northeastern University
22779702 53 Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.EBI Universit£ degli Studi di Siena
23036333 77 Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold.EBI Sapienza Universit£ di Roma
22651858 74 Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors.EBI Universit£ Catholique de Louvain
21899370 15 SAR and LC/MS studies ofß-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process.EBI Universit£ catholique de Louvain
22185522 159 Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.EBI Universidad Complutense de Madrid
21666860 14 Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.EBI Pfizer Inc.
18983142 135 Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.EBI Johnson& Johnson Pharmaceutical Research and Development
18657971 14 Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling.EBI The Scripps Research Institute
18630870 236 Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.EBI Institute for Chemical Biology
18424134 114 New tetrazole-based selective anandamide uptake inhibitors.EBI Sapienza Universit£ di Roma
18053726 364 Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.EBI Johnson& Johnson Pharmaceutical Research& Development
18247553 174 Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.EBI The Scripps Research Institute
18023188 86 Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).EBI University of California
18289847 35 Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).EBI Johnson& Johnson Pharmaceutical Research and Development
17561406 67 Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors.EBI Universit£ degli Studi di Siena
16279794 46 Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors.EBI Universit£ degli Studi di Siena
17279740 191 Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.EBI The Scripps Research Institute
16213718 93 New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies.EBI Institute of Biomolecular Chemistry
16078824 48 The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.EBI Universit£ Catholique de Louvain
12672252 104 Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.EBI Universidad Complutense
22209458 114 Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.EBI Vernalis (R&D) Ltd
22196515 14 Design, synthesis and evaluation of polar head group containing 2-keto-oxazole inhibitors of FAAH.EBI Max-Planck Institute of Molecular Physiology
22056744 16 Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone.EBI Universit£ catholique de Louvain
21764305 79 The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).EBI The Scripps Research Institute
21612933 17 New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.EBI Universit£ Lille Nord de France
21428410 78 Reversible competitivea-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.EBI The Scripps Research Institute
21392988 87 Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.EBI Amgen Inc.
19029917 5 Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.EBI The Scripps Research Institute
18438404 13 Activation of the endocannabinoid system by organophosphorus nerve agents.EBI University of California
19088712 1 Decoding endocannabinoid signaling.EBI TBA
20591666 66 A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.EBI Università degli Studi di Milano
19875281 73 Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.EBI Sapienza Universit£ di Roma
19850474 5 Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.EBI Renovis, Inc
20036536 79 Oxime carbamate--discovery of a series of novel FAAH inhibitors.EBI Bristol-Myers Squibb Research& Development
20005725 61 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase.EBI University of M£nster
20143779 28 Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors.EBI University of Cagliari
20099888 105 Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.EBI The Scripps Research Institute
19924997 2 X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.EBI The Scripps Research Institute
19583260 102 Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.EBI Louvain Drug Research Institute
19877691 36 beta-Lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase.EBI Universite Catholique de Louvain
19539407 18 Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields.EBI Helsinki University of Technology
19515560 24 Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.EBI Vernalis (R&D) Ltd
19232787 71 The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.EBI University of Kuopio
19054678 12 Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH.EBI Ghent University
18831576 66 Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism.EBI Sapienza Università di Roma
18752948 34 Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.EBI University of California
18693015 85 Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.EBI Johnson & Johnson Pharmaceutical Research and Development
18644727 12 Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.EBI The Scripps Research Institute
18639454 55 Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.EBI The Scripps Research Institute
18547805 6 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors.EBI Université catholique de Louvain
18507372 31 Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.EBI Università degli Studi di Parma
17452063 30 Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.EBI Università di Roma La Sapienza
17764163 61 Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase.EBI Universidad Complutense
17665899 16 Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors.EBI Helsinki University of Technology
16854070 12 Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system.EBI University of Kuopio
16570928 16 Development of the first potential covalent inhibitors of anandamide cellular uptake.EBI Institute of Biomolecular Chemistry
15771430 129 Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.EBI The Scripps Research Institute
15713400 99 Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.EBI The Scripps Research Institute
15582420 37 Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase.EBI The Scripps Research Institute
15456244 25 Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies.EBI Università degli Studi di Parma
12951114 18 Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors.EBI University of California
12781177 7 Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues.EBI UMR CNRS 5074
12773040 41 Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.EBI Università degli Studi di Urbino Carlo Bo
12166944 48 Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase.EBI Utrecht University
11412972 13 alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution.EBI The Scripps Research Institute
10021942 46 Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition.EBI Scripps Research Institute
9871570 25 An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase.EBI Institute for Chemical Biology
22225576 11 Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide.BDB Umeň University
24831513 35 Functionalization of ▀-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System.BDB University of Bern , BŘhlstrasse 28, CH-3012 Bern, Switzerland.
16892344 13 Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring.BDB UniversitÓ degli Studi di Parma
21728345 8 Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency.BDB AstraZeneca Pharmaceuticals
15356216 48 Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential.BDB Farmaceutiche e Farmacologiche
19389627 2 Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.BDB Pfizer
17459705 26 Novel inhibitors of fatty acid amide hydrolase.BDB Bristol-Myers Squibb Company
17949010 16 Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.BDB Pfizer
16866524 4 The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.BDB The Scripps Research Institute
19072118 28 Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.BDB Abbott Laboratories
18983140 42 Discovery of Boronic Acids as Novel and Potent Inhibitors of Fatty Acid Amide Hydrolase.BDB University of Oxford
16844375 7 Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: comparison with two original compounds, OL-92 and JP104.BDB FUNDP
17559203 161 Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.BDB The Scripps Research Institute
18027904 78 New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain.BDB University of Rome La Sapienza