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69 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25922884 5 Top-down Targeted Metabolomics Reveals a Sulfur-Containing Metabolite with Inhibitory Activity against Angiotensin-Converting Enzyme in Asparagus officinalis.EBI RIKEN Center for Sustainable Resource Science
25016232 109 CoMFA and CoMSIA analysis of ACE-inhibitory, antimicrobial and bitter-tasting peptides.EBI Tianjin University
24735644 19 Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid- hydrolysis.EBI INSERM
23061607 10 Organosilicon molecules with medicinal applications.EBI University of California-Davis
3379417 5 Chemical and pharmaceutical studies on medicinal plants in Paraguay. Geraniin, an angiotensin-converting enzyme inhibitor from "paraparai mi," Phyllanthus niruri.EBI TBA
18078750 76 Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.EBI GlaxoSmithKline
9379435 30 Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.EBI University of Michigan
7629809 140 Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues.EBI University of Illinois at Chicago
8360884 134 Three-dimensional quantitative structure-activity relationship of angiotesin-converting enzyme and thermolysin inhibitors. II. A comparison of CoMFA models incorporating molecular orbital fields and desolvation free energies based on active-analog and complementary-receptor-field alignment rules.EBI Washington University
2991518 11 Synthesis and biological activity of carboxylic acid replacement analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline.EBI TBA
2991517 4 Synthesis and biological activity of pentapeptide analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline.EBI TBA
2984419 21 Angiotensin-converting enzyme inhibitors: synthesis and biological activity of acyl tripeptide analogues of enalapril.EBI TBA
 20 Dual metalloprotease inhibitors. III. utilization of bicyclic and monocyclic diazepinone based mercaptoacetylsEBI TBA
 26 Dual metalloprotease inhibitors. II. Effect of substitution and stereochemistry on benzazepinone based mercaptoacetylsEBI TBA
 30 Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptidesEBI TBA
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
21381769 56 Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.EBI Universite£ de Sherbrooke
22882079 26 Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.EBI Aarhus University
21780776 40 Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry.EBI Wroclaw University of Technology
19715320 87 Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.EBI University of Florida
19596577 26 Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.EBI Dipartimento di Chimica
18160283 26 Targeting ACE and ECE with dual acting inhibitors.EBI Universit£ de Montr£al
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
15658862 30 Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.EBI University Institute of Pathology
12852763 20 Computer-aided selection of potential antihypertensive compounds with dual mechanism of action.EBI Institute of Biomedical Chemistry of Russian Academy of Medical Sciences
12477342 27 2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.EBI Merck Research Laboratories
10669559 180 Protease inhibitors: current status and future prospects.EBI University of Queensland
10882358 62 Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.EBI F. Hoffmann-La Roche Ltd.
10508425 68 Mixture-based synthetic combinatorial libraries.EBI Torrey Pines Institute for Molecular Studies
8021926 41 New thiol inhibitors of neutral endopeptidase EC synthesis and enzyme active-site recognition.EBI INSERM
8340909 14 Excursions in drug discovery.EBI Merck Research Laboratories
1995872 5 Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors.EBI University of Calgary
2544729 8 Angiotensin converting enzyme inhibitors: spirapril and related compounds.EBI Schering-Plough Corporation
2566685 47 Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements.EBI University of Wisconsin-Madison
2913292 23 Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives.EBI Tanabe Seiyaku Co., Ltd.
3005569 17 Conformationally restricted inhibitors of angiotensin converting enzyme: synthesis and computations.EBI TBA
3020249 29 Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.EBI TBA
2993618 19 Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.EBI TBA
2983076 2 Conformational analysis and active site modelling of angiotensin-converting enzyme inhibitors.EBI TBA
2999394 21 Angiotensin converting enzyme inhibitors: structure-activity profile of 1-benzazepin-2-one derivatives.EBI TBA
 20 4-Substituted proline derivatives that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11.EBI TBA
 11 Thiol and hydroxamic acid containing inhibitors of endothelin converting enzymeEBI TBA
19949058 15 Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist.EBI GlaxoSmithKline Research and Development
19899765 69 Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.EBI CEA, DSV, Service d'Ingenierie Moleculaire des Proteines (SIMOPRO)
19703773 63 The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.EBI GSK Medicines Research Centre
1517742 9 Inhibition of Angiotensin-I-Converting Enzyme by Tetrahydroxyxanthones Isolated from Tripterospermum lanceolatumEBI TBA
 23 Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosetsEBI TBA
 7 The design of a dipeptide library for screening at peptide receptor sitesEBI TBA
 2 Synthesis of 6-amino-5-oxo-7-phenyl-1,4-oxazepines as conformationally constrained gauche (−) dipeptide mimeticsEBI TBA
 1 An acyliminium ion route to Cis and Trans "Anti" phe-gly dipeptide mimeticsEBI TBA
19042128 76 Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors.EBI Santen Pharmaceutical Co., Ltd
18790648 317 Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.EBI University of Athens
18701300 55 Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides.EBI University of Leipzig
18674901 32 Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.EBI Santen Pharmaceutical Co., Ltd
16784850 14 Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.EBI University of Cape Town
16784843 4 Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme.EBI University of Cape Town
16464585 4 Structure-activity relationship study between Ornithyl-Proline and Lysyl-Proline based tripeptidomimics as angiotensin-converting enzyme inhibitors.EBI Institute of Genomics and Integrative Biology
11551755 18 Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.EBI British Biotech Pharmaceuticals Limited
11384231 26 2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.EBI F. Hoffmann-La Roche Ltd.
9484512 130 Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives.EBI Shionogi & Co., Ltd.
9046341 44 Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.EBI CIBA-GEIGY Corporation
8421293 32 Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors.EBI INSERM
8057292 83 Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives.EBI Schering-Plough Research Institute
7966160 7 PRO_LIGAND: an approach to de novo molecular design. 2. Design of novel molecules from molecular field analysis (MFA) models and pharmacophores.EBI Proteus Molecular Design Ltd.
20817735 24 Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.BDB Commissariat à l'Energie Atomique
15831442 46 Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.BDB Taisho Pharmaceutical Co., Ltd
18324760 34 Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2.BDB University of Athens