BindingDB logo
myBDB logout

82 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27216999 30 Protective effect of novel substituted nicotine hydrazide analogues against hypoxic brain injury in neonatal rats via inhibition of caspase.EBI The Fifth Affiliated Hospital of Guangzhou Medical University
25171780 7 Design, synthesis, and structure-activity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents.EBI Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Ministry of Education
25011914 2 In vitro induction of apoptosis by isosclerone from marine-derived fungus Aspergillus fumigatus.EBI Pukyong National University
25468037 76 Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors.EBI TBA
25358116 84 Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis.EBI Westf£lische Wilhelms-Universit£t M£nster
24656804 44 1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors.EBI Tianjin University of Science and Technology
23685941 53 Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7.EBI Westf£lische Wilhelms-Universit£t M£nster
23632366 33 Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors.EBI NanKai University
23656488 18 Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography.EBI Westf£lische Wilhelms-Universit£t M£nster
23411396 60 Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: nonradioactive counterparts of putative PET-compatible apoptosis imaging agents.EBI Westf£lische Wilhelms-Universit£t M£nster
22503362 35 New description of protein-ligand interactions using a spherical self-organizing map.EBI Chugai Pharmaceutical Company
22224594 346 Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.EBI Evotec (UK) Ltd.
22652225 27 A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions.EBI Southern Medical University
22276851 4 Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum.EBI University of Montana
21324681 23 Isatin 1,2,3-triazoles as potent inhibitors against caspase-3.EBI University of Oslo
19715320 87 Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.EBI University of Florida
16870441 30 Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors.EBI Procter and Gamble Pharmaceuticals Inc
16046125 18 Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis.EBI Procter& Gamble Pharmaceuticals, Inc.
15214773 76 Fragment-based drug discovery.EBI Sunesis Pharmaceuticals Inc.
10669559 180 Protease inhibitors: current status and future prospects.EBI University of Queensland
14980679 30 Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.EBI Maxim Pharmaceuticals
9873373 20 Peptidyl beta-homo-aspartals: specific inhibitors of interleukin-1 beta converting enzyme and its homologues (caspases).EBI Institute for Drug Research
21903398 88 Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.EBI CHDI Management, Inc.
21439692 8 Aspartic vinyl sulfones: inhibitors of a caspase-3-dependent pathway.EBI University of Lisbon
21441025 147 Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay.EBI Washington University School of Medicine
20541849 21 Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study.EBI University of Lisbon
20154666 1 Turning enzymes ON with small molecules.EBI University of California
17948018 17 Mechanisms, biology and inhibitors of deubiquitinating enzymes.EBI Institute for Biomedical Research
19631549 18 Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach.EBI Osmania University College for Women
19445513 82 Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis.EBI Westfalische Wilhelms-Universitat
19299147 60 Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors.EBI Westfälische Wilhelms-Universität
19049429 70 Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.EBI Imperial College London
18387304 4 Structure-based discovery of a novel non-peptidic small molecular inhibitor of caspase-3.EBI Tokyo University of Science
17889532 23 Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P(2) amino acid by 2-aminoaryl acids and other non-natural amino acids.EBI EpiCept Corporation
17585855 65 Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.EBI Washington University School of Medicine
17251019 30 Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.EBI Merck Frosst Centre for Therapeutic Research
17181147 10 Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo.EBI University of Edinburgh
17154501 121 5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.EBI University Hospital of the Westfälische Wilhelms-Universität
17127070 61 Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors.EBI Procter & Gamble Pharmaceuticals, Inc.
16891117 5 Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis.EBI Washington University School of Medicine
16782334 61 Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors.EBI Procter & Gamble Pharmaceuticals
16216507 87 Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme inhibitors.EBI Procter & Gamble Pharmaceuticals, Inc.
16078840 94 Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers and potential anticancer agents.EBI Maxim Pharmaceuticals Inc.
16046129 18 Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: inhibition of interleukin-1beta-converting enzyme.EBI Procter & Gamble Pharmaceuticals
15808464 32 Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.EBI Merck Research Laboratories
15713391 19 Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid.EBI Maxim Pharmaceuticals
15686936 210 Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.EBI Merck Frosst Centre for Therapeutic Research
15588079 1 Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3.EBI University of Illinois at Chicago
15454214 26 Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group.EBI Maxim Pharmaceuticals
15109679 15 Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.EBI Idun Pharmaceuticals, Inc.
14505683 6 Structure-activity relationships within a series of caspase inhibitors: effect of leaving group modifications.EBI Idun Pharmaceuticals, Inc.
12270186 99 Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.EBI Idun Pharmaceuticals, Inc.
12270185 257 Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.EBI Idun Pharmaceuticals, Inc.
12127536 22 Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis.EBI Merck Research Laboratories
10978183 40 Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery.EBI BASF Bioresearch Corporation
9873617 30 Conformationally constrained inhibitors of caspase-1 (interleukin-1 beta converting enzyme) and of the human CED-3 homologue caspase-3 (CPP32, apopain).EBI Idun Pharmaceuticals
28238723 39 Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.BDB University of Colorado
15831442 46 Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.BDB Taisho Pharmaceutical Co., Ltd
16936720 11 Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.BDB University of Illinois
19836248 35 3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3.BDB Wyeth Research
19326941 104 Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.BDB Washington University
17649976 16 Biochemical and biophysical characterization of inhibitor binding to caspase-3 reveals induced asymmetry.BDB Wyeth Research
14741294 72 Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.BDB Merck Frosst Canada & Co.
15115390 8 Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.BDB Merck Research Laboratories
12798321 26 Nicotinyl aspartyl ketones as inhibitors of caspase-3.BDB Merck Frosst Canada & Co.
16023344 120 Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.BDB Merck Frosst Canada & Co.
15780618 29 1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3 inhibitors.BDB Chemical Diversity Research Institute
15916416 18 Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors.BDB Chemical Diversity Research Institute
16302804 145 N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.BDB Washington University School of Medicine
11384246 86 Potent and selective nonpeptide inhibitors of caspases 3 and 7.BDB GlaxoSmithKline
16509578 79 Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.BDB Shanghai Institutes for Biological Sciences
15743206 33 Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach.BDB Burnham Institute
14552750 35 Identification of potent and novel small-molecule inhibitors of caspase-3.BDB Sunesis Pharmaceuticals
9829999 2 Inhibition of human caspases by peptide-based and macromolecular inhibitors.BDB Merck Research Laboratories
12408711 112 Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.BDB Sunesis Pharmaceuticals