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74 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27810438 49 Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains.EBI Shandong University
27994761 48 Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins.EBI Wuhan University School of Pharmaceutical Sciences
27712939 63 Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites.EBI China Pharmaceutical University
27353532 6 Structural modification of luteolin from Flos Chrysanthemi leads to increased tumor cell growth inhibitory activity.EBI Second Military Medical University
26988306 12 Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity.EBI AstraZeneca
26558516 39 Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors.EBI Shandong University
26421995 49 Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors.EBI Shandong University
26181851 26 Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors.EBI Novartis Institutes for BioMedical Research
25844895 61 Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design.EBI Vanderbilt University School of Medicine
25679114 48 Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.EBI AbbVie Inc.
25668341 50 Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.EBI Universit£ di Napoli"Federico II"
25818766 45 Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors.EBI Shandong University
25011914 2 In vitro induction of apoptosis by isosclerone from marine-derived fungus Aspergillus fumigatus.EBI Pukyong National University
24881567 73 Towards the next generation of dual Bcl-2/Bcl-xL inhibitors.EBI AstraZeneca
25313317 51 Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.EBI AbbVie, Inc.
24944740 37 Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.EBI Genentech
24749893 123 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.EBI University of Michigan Medical School
24095762 18 Design and application of a rigid quinazolone scaffold based on two-face Bima-helix mimicking.EBI Dalian University of Technology
23767404 97 Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.EBI The Walter and Eliza Hall Institute of Medical Research
23474389 2 Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents.EBI Cardiff University
23448298 58 A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.EBI University of Michigan
23314054 41 Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors.EBI Dalian University of Technology
23244564 114 Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.EBI Vanderbilt University School of Medicine
23206987 66 3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.EBI Dalian University of Technology
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
23167494 18 An anthraquinone scaffold for putative, two-face Bim BH3a-helix mimic.EBI Dalian University of Technology
23047228 24 Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators.EBI Clermont Universit£
23030453 58 Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.EBI University of Michigan
22448988 77 Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold.EBI University of Michigan
22608961 46 Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists.EBI Bristol-Myers Squibb Research
22608393 64 Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.EBI Bristol-Myers Squibb Research
20443627 26 BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.EBI Sanford-Burnham Medical Research Institute
18023349 30 Development of dimeric modulators for anti-apoptotic Bcl-2 proteins.EBI University of Minnesota Minneapolis
18237106 18 Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins.EBI TBA
17227711 40 Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1.EBI University of Minnesota
11728179 12 Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.EBI Georgetown University Medical Center
22172701 40 Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.EBI Second Military Medical University
21684048 20 Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.EBI Dalian University of Technology
21366295 40 Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.EBI The Walter and Eliza Hall Institute of Medical Research
21235240 24 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship studies.EBI Dalian University of Technology
21033669 96 Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.EBI Sanford-Burnham Medical Research Institute
20925433 21 Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.EBI Aristotle University of Thessaloniki
20870405 31 Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.EBI Abbott Laboratories
20405848 48 Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.EBI Chinese Academy of Sciences
20441222 37 Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention.EBI Institute for Medical Research
19329314 32 Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.EBI Infinity Pharmaceuticals, Inc.
19217289 8 Atropisomeric small molecule Bcl-2 ligands: determination of bioactive conformation.EBI UCB Celltech
19027294 80 Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors.EBI UCB Celltech
18841882 3 Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins.EBI Abbott Laboratories
17692431 48 Structure-activity relationships of Bak derived peptides: affinity and specificity modulations by amino acid replacement.EBI INSERM
17552510 9 Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.EBI University of Michigan
17378545 10 Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.EBI University of Michigan
17181155 23 Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer.EBI University of Minnesota
17034116 28 Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.EBI University of Michigan
16451081 132 Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.EBI Abbott Laboratories
16137879 16 A chemical strategy to promote helical peptide-protein interactions involved in apoptosis.EBI University of Illinois at Urbana-Champaign
28026162 41 hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.BDB University of California, Riverside
23603658 33 Structure-guided design of a selective BCL-X(L) inhibitor.BDB Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
19555126 38 Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.BDB Burnham Institute for Medical Research
17256834 104 Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.BDB Abbott Laboratories