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17 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25679114 48 Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.EBI AbbVie Inc.
25313317 51 Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.EBI AbbVie, Inc.
24944740 37 Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.EBI Genentech
24749893 123 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.EBI University of Michigan Medical School
23767404 97 Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.EBI The Walter and Eliza Hall Institute of Medical Research
18040043 5 Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.EBI McGill University
18023349 30 Development of dimeric modulators for anti-apoptotic Bcl-2 proteins.EBI University of Minnesota Minneapolis
17227711 40 Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1.EBI University of Minnesota
21807512 29 Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.EBI University of Washington
21366295 40 Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.EBI The Walter and Eliza Hall Institute of Medical Research
18583128 3 Isosteric exchange of the acylsulfonamide moiety in Abbott's Bcl-XL protein interaction antagonist.EBI University of Pittsburgh
17181155 23 Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer.EBI University of Minnesota
16451081 132 Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.EBI Abbott Laboratories
16427279 3 Design and modular parallel synthesis of a MCR derived alpha-helix mimetic protein-protein interaction inhibitor scaffold.EBI ABC Pharma
23603658 33 Structure-guided design of a selective BCL-X(L) inhibitor.BDB Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia