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38 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
24900877 107 Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.EBI Merck Research Laboratories
19715320 87 Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.EBI University of Florida
16870441 30 Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors.EBI Procter and Gamble Pharmaceuticals Inc
16046125 18 Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis.EBI Procter& Gamble Pharmaceuticals, Inc.
3258925 5 Melanin concentrating hormone analogues: contraction of the cyclic structure. 1. Agonist activity.EBI University of Arizona
14980679 30 Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.EBI Maxim Pharmaceuticals
21441025 147 Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay.EBI Washington University School of Medicine
20170165 13 Noncovalent tripeptidyl benzyl- and cyclohexyl-amine inhibitors of the cysteine protease caspase-1.EBI The University of Queensland
19049429 70 Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.EBI Imperial College London
18387304 4 Structure-based discovery of a novel non-peptidic small molecular inhibitor of caspase-3.EBI Tokyo University of Science
17935298 3 Planktocyclin, a cyclooctapeptide protease inhibitor produced by the freshwater cyanobacterium Planktothrix rubescens.EBI University of Zürich
17889532 23 Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P(2) amino acid by 2-aminoaryl acids and other non-natural amino acids.EBI EpiCept Corporation
17585855 65 Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.EBI Washington University School of Medicine
17251019 30 Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.EBI Merck Frosst Centre for Therapeutic Research
17181147 10 Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo.EBI University of Edinburgh
17154501 121 5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.EBI University Hospital of the Westfälische Wilhelms-Universität
17127070 61 Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors.EBI Procter & Gamble Pharmaceuticals, Inc.
16891117 5 Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis.EBI Washington University School of Medicine
16782334 61 Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors.EBI Procter & Gamble Pharmaceuticals
16216507 87 Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme inhibitors.EBI Procter & Gamble Pharmaceuticals, Inc.
16046129 18 Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: inhibition of interleukin-1beta-converting enzyme.EBI Procter & Gamble Pharmaceuticals
15713391 19 Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid.EBI Maxim Pharmaceuticals
15686936 210 Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.EBI Merck Frosst Centre for Therapeutic Research
15454214 26 Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group.EBI Maxim Pharmaceuticals
15109679 15 Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.EBI Idun Pharmaceuticals, Inc.
12270186 99 Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.EBI Idun Pharmaceuticals, Inc.
12270185 257 Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.EBI Idun Pharmaceuticals, Inc.
12127536 22 Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis.EBI Merck Research Laboratories
19326941 104 Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.BDB Washington University
14741294 72 Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.BDB Merck Frosst Canada & Co.
16023344 120 Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.BDB Merck Frosst Canada & Co.
16302804 145 N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.BDB Washington University School of Medicine
11384246 86 Potent and selective nonpeptide inhibitors of caspases 3 and 7.BDB GlaxoSmithKline
16509578 79 Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.BDB Shanghai Institutes for Biological Sciences
15743206 33 Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach.BDB Burnham Institute
12408711 112 Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.BDB Sunesis Pharmaceuticals