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40 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27216999 30 Protective effect of novel substituted nicotine hydrazide analogues against hypoxic brain injury in neonatal rats via inhibition of caspase.EBI The Fifth Affiliated Hospital of Guangzhou Medical University
25468037 76 Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors.EBI TBA
25358116 84 Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis.EBI Westf£lische Wilhelms-Universit£t M£nster
24656804 44 1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors.EBI Tianjin University of Science and Technology
23685941 53 Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7.EBI Westf£lische Wilhelms-Universit£t M£nster
23656488 18 Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography.EBI Westf£lische Wilhelms-Universit£t M£nster
23411396 60 Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: nonradioactive counterparts of putative PET-compatible apoptosis imaging agents.EBI Westf£lische Wilhelms-Universit£t M£nster
19715320 87 Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.EBI University of Florida
14980679 30 Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.EBI Maxim Pharmaceuticals
21441025 147 Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay.EBI Washington University School of Medicine
20541849 21 Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study.EBI University of Lisbon
19445513 82 Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis.EBI Westfalische Wilhelms-Universitat
19299147 60 Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors.EBI Westfälische Wilhelms-Universität
19049429 70 Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.EBI Imperial College London
18387304 4 Structure-based discovery of a novel non-peptidic small molecular inhibitor of caspase-3.EBI Tokyo University of Science
17889532 23 Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P(2) amino acid by 2-aminoaryl acids and other non-natural amino acids.EBI EpiCept Corporation
17585855 65 Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.EBI Washington University School of Medicine
17251019 30 Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.EBI Merck Frosst Centre for Therapeutic Research
17181147 10 Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo.EBI University of Edinburgh
17154501 121 5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.EBI University Hospital of the Westfälische Wilhelms-Universität
16891117 5 Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis.EBI Washington University School of Medicine
15713391 19 Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid.EBI Maxim Pharmaceuticals
15686936 210 Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.EBI Merck Frosst Centre for Therapeutic Research
15454214 26 Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group.EBI Maxim Pharmaceuticals
12270186 99 Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.EBI Idun Pharmaceuticals, Inc.
12270185 257 Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.EBI Idun Pharmaceuticals, Inc.
10978183 40 Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery.EBI BASF Bioresearch Corporation
16936720 11 Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.BDB University of Illinois
19326941 104 Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.BDB Washington University
14741294 72 Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.BDB Merck Frosst Canada & Co.
16023344 120 Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.BDB Merck Frosst Canada & Co.
16302804 145 N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.BDB Washington University School of Medicine
11384246 86 Potent and selective nonpeptide inhibitors of caspases 3 and 7.BDB GlaxoSmithKline
16509578 79 Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.BDB Shanghai Institutes for Biological Sciences
15743206 33 Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach.BDB Burnham Institute
12408711 112 Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.BDB Sunesis Pharmaceuticals