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95 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28041801 1 A one-pot laccase-catalysed synthesis of coumestan derivatives and their anticancer activity.EBI CSIR Biosciences
26638042 5 Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.EBI China Pharmaceutical University
26432605 8 5-Lipoxygenase inhibitors suppress RANKL-induced osteoclast formation via NFATc1 expression.EBI Sookmyung Women's University
25462262 98 Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.EBI Goethe-University Frankfurt
1848292 44 Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.EBI ICI Pharma
3806607 15 Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists.EBI TBA
 4 Cyclic aryl hydroxamic acids: synthesis and inhibition of 5-lipoxygenaseEBI TBA
22380511 73 Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.EBI Peking University
22749420 13 Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.EBI University of Hamburg
9207936 198 Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors.EBI Abbott Laboratories
8831759 16 1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.EBI SmithKline Beecham Pharmaceuticals
7932529 37 Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.EBI Eisai Company, Ltd.
8478906 25 Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.EBI Warner-Lambert Company
1433181 19 Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors.EBI Warner-Lambert Company
1635053 37 5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.EBI Wyeth-Ayerst Research
2113951 68 1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.EBI Pfizer Central Research
2104936 77 2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.EBI E. I. du Pont de Nemours and Company, Inc.
3133478 8 4-Hydroxy-3-quinolinecarboxamides with antiarthritic and analgesic activities.EBI Centre de Recherches Roussel Uclaf
3599023 29 Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues.EBI TBA
3820229 51 Hydroxamic acid inhibitors of 5-lipoxygenase.EBI TBA
3806609 30 Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues.EBI TBA
3681891 27 Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity.EBI Beecham Pharmaceuticals--Research Division
15109651 54 Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities.EBI Yeungnam University
 35 Antiinflammatory -benzeneethanamines. IIIEBI TBA
 22 Topical antiinflammatory dehydroabietylamine derivatives. IVEBI TBA
21958738 6 Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.EBI Universiti Putra Malaysia
20870413 14 Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors.EBI Ewha Womans University
 39 O-alkylcarboxylate oxime and N-hydroxyurea analogs of substituted indole leukotriene biosynthesis inhibitorsEBI TBA
 19 Catechol based inhibitors of 15-lipoxygenaseEBI TBA
 42 Cmi-206: A potent dual platelet activating factor antagonist and 5-lipoxygenase inhibitorEBI TBA
 8 Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonistsEBI TBA
 76 2,4,5- triarylimidazole inhibitors of IL-1 biosynthesisEBI TBA
 14 A novel series of highly potent 5-lipoxygenase inhibitors; 2-aryldienylbenzoxazolesEBI TBA
 13 Design of pyrrolo-1,4-benzoxazine derivatives as inhibitors of 5-lipoxygenase and PAF antagonists with anthihistaminic propertiesEBI TBA
 12 4-[5-(2,3-dihydroxyphenyl)pentyloxy]-2-hydroxy-3-propylbenzoic acid (Ro 24-0553): an orally active 5-lipoxygenase inhibitor with antiinflammatory activityEBI TBA
 11 Cyclooxygenase and 5-lipoxygenase inhibitory activity of 2,6 di-t-butylphenols linked by a sulfur atom to 1,3,4-thiadiazoles and 1,3,4-oxadiazolesEBI TBA
 24 Vinylogous hydroxamic acids: 5-lipoxygenase inhibitorsEBI TBA
 11 Synthesis and cyclooxygenase and 5-lipoxygenase inhibitory activity of some thiazolidene-4-one analogs of meclofenamic acidEBI TBA
 17 Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitorsEBI TBA
 16 Synthesis of reversed hydroxamic acids of indomethacin: dual inhibitors of cyclooxygenase and 5-lipoxygenaseEBI TBA
 21 1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitorEBI TBA
 19 Structural analysis of 2-aryl-1,3-dione compounds as inhibitors of 5-lipoxygenaseEBI TBA
 14 Conversion of NSAIDS into balanced dual inhibitors of cyclooxygenase and 5-lipoxygenaseEBI TBA
10514305 4 Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation.EBI Peking Union Medical College and Chinese Academy of Medical Sciences
17336065 12 Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling.EBI Chinese Academy of Sciences
15081022 20 5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.EBI UCB Research
11277534 3 N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.EBI Université de Lille 2
10230624 110 N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.EBI The R.W. Johnson Pharmaceutical Research Institute
9599246 28 (+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.EBI University of Virginia
9544212 37 New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.EBI Procter & Gamble Pharmaceuticals
9484493 11 Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.EBI OXIS International, Inc.
9371243 57 Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity.EBI Westfälische Wilhelms-Universität Münster
9276024 42 Antipsoriatic anthrones with modulated redox properties. 4. Synthesis and biological activity of novel 9,10-dihydro-1,8-dihydroxy-9-oxo-2-anthracenecarboxylic and -hydroxamic acids.EBI Westfälische Wilhelms-Universität Münster
9057869 25 Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.EBI Abbott Laboratories
8978834 33 Bicyclic N-hydroxyurea inhibitors of 5-lipoxygenase: pharmacodynamic, pharmacokinetic, and in vitro metabolic studies characterizing N-hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea.EBI SmithKline Beecham Pharmaceuticals
8831760 108 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.EBI Abbott Laboratories
8809171 13 (E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity.EBI SmithKline Beecham Pharmaceuticals
8759634 54 Antipsoriatic anthrones with modulated redox properties. 3. 10-thio-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of keratinocyte growth, 5-lipoxygenase, and the formation of 12(S)-HETE in mouse epidermis.EBI Universität Regensburg
8568814 23 Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity.EBI Hoechst-Roussel Pharmaceuticals Inc.
8515419 14 1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.EBI Warner-Lambert Company
8410991 88 Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.EBI Merck Frosst Centre for Therapeutic Research
8295221 28 Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.EBI Warner-Lambert Company
8289184 45 Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series.EBI Centre de Recherches
8258834 46 Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase.EBI Universität Regensburg
8254620 57 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.EBI Tokushima Bunri University
8201600 41 Antipsoriatic anthrones with modulated redox properties. 2. Novel derivatives of chrysarobin and isochrysarobin--antiproliferative activity and 5-lipoxygenase inhibition.EBI Universität Regensburg
8151626 4 Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR.EBI Du Pont Merck Pharmaceutical Company
8021931 19 (6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.EBI Merckle GmbH
7932593 24 Synthesis and 5-lipoxygenase inhibitory activities of some novel 2-substituted 5-benzofuran hydroxamic acids.EBI R. W. Johnson Pharmaceutical Research Institute
7739006 2 Synthesis and antiinflammatory activity of certain 5,6,7,8-tetrahydroquinolines and related compounds.EBI Wyeth Research (U.K.) Ltd.
3806620 15 Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters.EBI TBA
3783588 51 Syntheses of 5,6,7- and 5,7,8-trioxygenated 3',4'-dihydroxyflavones having alkoxy groups and their inhibitory activities against arachidonate 5-lipoxygenase.EBI TBA
3669019 11 In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase.EBI Abbott Laboratories
3336029 8 Orally active hydroxamic acid inhibitors of leukotriene biosynthesis.EBI Abbott Laboratories
3172130 35 Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis.EBI Abbott Laboratories
3090264 25 Synthesis of [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors.EBI TBA
2878078 43 Synthesis and antiallergic activity of a novel series of 5-lipoxygenase inhibitors.EBI TBA
2542553 31 Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.EBI Merck Frosst Canada Inc.
2502629 81 Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.EBI Rorer Central Research
2498516 2 N-[(arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene D4 antagonists of novel structure.EBI Wyeth-Ayerst Research
2319562 12 Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes.EBI Molecular Therapeutics Inc.
2308149 218 Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships.EBI Abbott Laboratories
2213827 48 Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.EBI Centre de Recherches de Vitry
2115586 16 Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.EBI Warner-Lambert Company
2104935 6 N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.EBI Wyeth-Ayerst Research
2066989 89 4-hydroxythiazole inhibitors of 5-lipoxygenase.EBI Abbott Laboratories
2016727 30 Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase.EBI Institute for Biomedical Research
1992126 54 Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.EBI Takeda Chemical Industries, Ltd.
1903450 32 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones.EBI Sterling Research Group
1847426 28 Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.EBI Warner-Lambert Company
1648621 50 (Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.EBI ICI Pharmaceuticals
1507204 12 Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.EBI Du Pont Merck Pharmaceutical Company
1433212 59 Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis.EBI Du Pont Merck Pharmaceutical Company
1313879 21 Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.EBI Merck Frosst Centre For Therapeutic Research