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65 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27994765 95 Discovery of Highly Potent Liver X Receptor▀ Agonists.EBI Bristol-Myers Squibb
27599745 106 Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.EBI Vitae Pharmaceuticals
27283790 33 Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and▀-selectivity of liver X receptor agonist.EBI Kowa Co., Ltd
26990539 79 Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR)▀ Agonist.EBI Vitae Pharmaceuticals, Inc.
27011007 17 Identification and in Vivo Evaluation of Liver X Receptor▀-Selective Agonists for the Potential Treatment of Alzheimer's Disease.EBI WuXi AppTec Company, Ltd.
26819660 82 SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR┐ Inhibitor.EBI Central Pharmaceutical Research Institute
26905831 11 Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317.EBI The University of Tokyo
26288691 54 Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators.EBI The University of Tokyo
26321361 56 Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.EBI Genentech
26238323 12 Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists.EBI Daiichi Sankyo RD Novare Co., Ltd
26048793 91 Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.EBI Genentech
25998501 79 Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptor▀-selective agonists.EBI Kowa Co., Ltd
25815138 58 Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.EBI Genentech
25677664 30 Design and discovery of 2-oxochromene derivatives as liver X receptor▀-selective agonists.EBI Kowa Co., Ltd
25017032 62 Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.EBI Genentech
24502334 123 Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-┐ (ROR┐ or RORc).EBI Genentech
25453817 130 A reversed sulfonamide series of selective RORc inverse agonists.EBI Argenta Discovery Ltd.
25435151 34 Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXR▀.EBI Bristol-Myers Squibb
24702856 84 Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (ROR┐)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand.EBI The University of Tokyo
24685544 75 Identification of tertiary sulfonamides as RORc inverse agonists.EBI Genentech
24239186 84 Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.EBI Genentech
23769638 9 Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes.EBI Korea University
23656296 51 Optimized chemical probes for REV-ERBa.EBI GlaxoSmithKline
23246324 2 Induction of ABCA1 and ABCG1 expression by the liver X receptor modulator cineole in macrophages.EBI Korea University
24040486 30 Identification of Potent and Selective Diphenylpropanamide ROR? Inhibitors.EBI New York University School of Medicine
20345102 34 Discovery of tertiary sulfonamides as potent liver X receptor antagonists.EBI GlaxoSmithKline
22579484 6 Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.EBI Korea University
22873709 45 Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton.EBI The University of Tokyo
22406115 18 Discovery of a new binding mode for a series of liver X receptor agonists.EBI Amgen Inc.
21218783 117 Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.EBI Johnson& Johnson Pharmaceutical Research and Development
20005711 102 3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.EBI Wyeth Pharmaceuticals
15911262 38 Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters.EBI Merck Research Laboratories
20638278 145 Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI Phenex Pharmaceuticals AG
20382019 51 Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.EBI Wyeth Pharmaceuticals
20350005 45 Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist.EBI Wyeth Pharmaceuticals
20006495 62 1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists.EBI Wyeth Pharmaceuticals
19962892 48 Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration.EBI Wyeth Pharmaceuticals
19932617 46 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.EBI Wyeth Pharmaceuticals
19717304 29 The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages.EBI GlaxoSmithKline
19539483 78 Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.EBI The University of Tokyo
19394832 74 Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta.EBI Wyeth Research
19264481 58 Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides.EBI AstraZeneca R&D Södertälje
18800767 45 Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.EBI GlaxoSmithKline Research and Development
16180833 4 Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents.EBI Merck Research Laboratories
16124770 26 Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.EBI Merck Research Laboratories
15844964 2 Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand.EBI Merck Research Laboratories
18023179 58 Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.EBI Wyeth Pharmaceuticals
17498949 4 Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.EBI University of Tokyo
16876993 192 Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.EBI F. Hoffmann-La Roche Ltd.
16529931 139 SAR studies: designing potent and selective LXR agonists.EBI Merck Research Laboratories
16386417 27 Discovery and optimization of a novel series of liver X receptor-alpha agonists.EBI Amgen Inc.
16125384 109 Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis.EBI Merck Research Laboratories
12893846 3 A natural product ligand of the oxysterol receptor, liver X receptor.BDB Lilly Research Laboratories
19231176 48 Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator.BDB F. Hoffmann-La Roche Ltd
17416521 67 Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists.BDB Tanabe Research Laboratories USA
17587573 33 2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists.BDB Tanabe Research Laboratories USA
19167885 24 Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.BDB GSK
18343126 57 Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.BDB University of Tokyo
11300870 20 Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.BDB Dartmouth College
11985463 12 Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.BDB GlaxoSmithKline
16107141 22 Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.BDB GlaxoSmithKline
17665897 52 N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.BDB GNF