Data for Coronaviruses: COVID-19, MERS & SARS
Special Covid-19 pages are also available at BioGRID and Guide to Pharmacology.
PMID | Data | Article Title | Citation | Organization | Deposition | Files Download |
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WO2022043374A1 | 136 | Aminocarbamoyl compounds for the treatment of viral infections![]() |
WIPO WO2022043374A1 (2022) | F. Hoffmann-La Roche Ag | 03/30/22 | 2D 3D |
35344983 | 42 | A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic.![]() |
Nature (2022) | University of British Columbia | 03/30/22 | 2D 3D |
32845145 | 1 | Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).![]() |
J Med Chem 63: 13205-13227 (2020) | South China Agricultural University | 03/27/22 | 2D 3D |
10 | Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19![]() |
bioRxiv 2022: (2022) | Shionogi Pharmaceutical Research Center | 02/02/22 | 2D 3D | |
34798775 | 961 | Perspectives on SARS-CoV-2 Main Protease Inhibitors.![]() |
J Med Chem 64: 16922-16955 (2021) | Michigan State University | 01/27/22 | 2D 3D |
WO2021219089A1 | 190 | Sars-cov-2 inhibitors having covalent modifications for treating coronavirus infections![]() |
WIPO WO2021219089A1 (2021) | Insilico Medicine Ip Limited | 01/27/22 | 2D 3D |
WO2021250648A1 | 170 | Nitrile-containing antiviral compounds![]() |
WIPO WO2021250648A1 (2021) | Pfizer Inc. | 01/13/22 | 2D 3D |
US11124497 | 463 | Inhibitors of cysteine proteases and methods of use thereof![]() |
US Patent US11124497 (2021) | Pardes Biosciences, Inc. | 01/13/22 | 2D 3D |
WO2021205290A1 | 52 | Compounds and method of treating covid-19![]() |
WIPO WO2021205290A1 (2021) | Pfizer Inc. | 01/13/22 | 2D 3D |
WO2021205298A1 | 15 | Compounds and methods for the treatment of covid-19![]() |
WIPO WO2021205298A1 (2021) | Pfizer Inc. | 01/13/22 | 2D 3D |
34860011 | 49 | Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity.![]() |
J Am Chem Soc 143: 20697-20709 (2021) | The University of Arizona | 01/13/22 | 2D 3D |
34528437 | 44 | Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies.![]() |
J Med Chem 64: 14702-14714 (2021) | Purdue University | 11/05/21 | 2D 3D |
34651447 | 87 | A patent review on SARS coronavirus main protease (3CLpro) inhibitors.![]() |
ChemMedChem (2021) | Experimental Drug Development Centre | 11/05/21 | 2D 3D |
2159 | Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitor Therapeutics![]() |
bioRxiv 2021: (2021) | Israel Institution of Biological Research | 11/05/21 | 2D 3D | |
12 | An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19![]() |
Science 374: 1-13 (2021) | Pfizer | 11/05/21 | 2D 3D | |
34665619 | 189 | Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity.![]() |
J Med Chem (2021) | University of Illinois at Chicago | 11/05/21 | 2D 3D |
34426525 | 6 | DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M![]() |
Proc Natl Acad Sci U S A 118: (2021) | Baylor College of Medicine | 09/11/21 | 2D 3D |
34414360 | 60 | Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir.![]() |
ACS Pharmacol Transl Sci 4: 1408-1421 (2021) | The University of Arizona | 09/10/21 | 2D 3D |
34408808 | 72 | Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.![]() |
ACS Med Chem Lett 12: 1325-1332 (2021) | Yale University | 09/10/21 | 2D 3D |
34347470 | 98 | Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL![]() |
J Med Chem 64: (2021) | Cleveland Clinic | 08/14/21 | 2D 3D |
32150407 | 27 | Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-?-lactamases.![]() |
J Med Chem 63: 7491-7507 (2020) | Qpex Biopharma, Inc. | 08/13/21 | 2D 3D |
34271072 | 34 | A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors.![]() |
Bioorg Med Chem Lett 48: 128263 (2021) | A*STAR | 07/29/21 | 2D 3D |
34213885 | 38 | Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease.![]() |
J Med Chem 64: 10047-10058 (2021) | Wichita State University | 07/29/21 | 2D 3D |
34408808 | 72 | Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency![]() |
ACS Med Chem Lett 12: 1325-1332 (2021) | Yale University | 07/29/21 | 2D 3D |
34242027 | 24 | Peptidomimetic ?-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and ![]() |
J Med Chem (2021) | University of Alberta | 07/29/21 | 2D 3D |
US10874687 | 12 | Highly active compounds against COVID-19![]() |
US Patent US10874687 (2020) | Atea Pharmaceuticals, Inc. | 07/25/21 | 2D 3D |
US10874683 | 39 | N4-hydroxycytidine and derivatives and anti-viral uses related thereto![]() |
US Patent US10874683 (2020) | Emory University | 07/25/21 | 2D 3D |
37 | Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations![]() |
ACS Cent Sci (2021) | Yale University | 02/28/21 | 2D 3D | |
33602867 | 54 | SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model![]() |
Science (2021) | Sichuan University | 02/28/21 | 2D 3D |
30940566 | 17 | Identification and design of novel small molecule inhibitors against MERS-CoV papain-like protease via high-throughput screening and molecular modeling.![]() |
Bioorg Med Chem 27: 1981-1989 (2019) | University of Illinois at Chicago | 02/24/21 | 2D 3D |
32030982 | 14 | The Other Angiotensin II Receptor: AT![]() |
J Med Chem 63: 1978-1995 (2020) | Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) | 02/21/21 | 2D 3D |
WO2006061714A2 | 12 | Anticoronaviral compounds and compositions, their pharmaceutical uses and materials for their synthesis![]() |
WIPO WO2006061714A2 (2006) | Pfizer Inc. | 01/31/21 | 2D 3D |
9 | Inhibition of SARS-CoV-2 main protease by allosteric drug-binding![]() |
bioRxiv 2020: (2020) | Center for Free-Electron Laser Science | 01/31/21 | 2D 3D | |
33283984 | 11 | A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors![]() |
ChemMedChem (2020) | Texas A&M University | 01/31/21 | 2D 3D |
43 | Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen![]() |
bioRxiv 2020: (2020) | Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP) and Fraunhofer Cluster of Excellence for Immune mediated diseases (CIMD) | 01/31/21 | 2D 3D | |
32366720 | 53 | Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs.![]() |
Antimicrob Agents Chemother 64: (2020) | Institut Pasteur Korea | 11/13/20 | 2D 3D |
32253226 | 4 | An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.![]() |
Sci Transl Med 12: 1-15 (2020) | University of North Carolina at Chapel Hill | 11/13/20 | 2D 3D |
32852058 | 301 | The recent outbreaks of human coronaviruses: A medicinal chemistry perspective.![]() |
Med Res Rev (2020) | University of Bonn | 11/07/20 | 2D 3D |
26878082 | 196 | An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.![]() |
J Med Chem 59: 6595-628 (2016) | University of Bonn | 11/07/20 | 2D 3D |
WO2005113580A1 | 101 | Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis![]() |
WIPO WO2005113580A1 (2005) | Pfizer Inc. | 10/17/20 | 2D 3D |
US9975885 | 182 | Broad-spectrum non-covalent coronavirus protease inhibitors![]() |
US Patent US9975885 (2018) | PURDUE RESEARCH FOUNDATION | 09/25/20 | 2D 3D |
32321856 | 4 | Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.![]() |
Science 368: 1331-1335 (2020) | Shanghai Institute of Materia Medica | 09/21/20 | 2D 3D |
25122198 | 5 | The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.![]() |
Cancer Discov 4: 1310-25 (2014) | Fred Hutchinson Cancer Research Center | 09/21/20 | 2D 3D |
32428392 | 7 | Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease.![]() |
ACS Infect Dis 6: 2099-2109 (2020) | University of Georgia | 09/21/20 | 2D 3D |
32198291 | 3 | Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved ?-ketoamide inhibitors.![]() |
Science 368: 409-412 (2020) | University of Lubeck | 09/21/20 | 2D 3D |
32803196 | 48 | Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening.![]() |
bioRxiv (2020) | National Institutes of Health | 09/21/20 | 2D 3D |
32935104 | 12 | Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19.![]() |
bioRxiv (2020) | Pfizer Inc. | 09/21/20 | 2D 3D |
4 | Discovery of potent inhibitors of PLproCoV2 by screening a library of selenium-containing compounds![]() |
bioRxiv 1-12 (2020) | University ofAmsterdam | 09/21/20 | 2D 3D | |
15950190 | 10 | Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease.![]() |
Biochem Biophys Res Commun 333: 194-9 (2005) | National Taiwan University | 09/21/20 | 2D 3D |
32747425 | 43 | 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice.![]() |
Sci Transl Med 12: (2020) | Wichita State University | 09/06/20 | 2D 3D |
32272481 | 9 | Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors ![]() |
Nature 582: 289-293 (2020) | ShanghaiTech University | 09/06/20 | 2D 3D |
24332657 | 35 | Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings.![]() |
Bioorg Med Chem 22: 167-77 (2014) | University of Illinois at Chicago | 09/02/20 | 2D 3D |
24316352 | 27 | Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors.![]() |
Bioorg Med Chem 22: 292-302 (2014) | Tianjin University of Science and Technology | 09/02/20 | 2D 3D |
23647823 | 27 | Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.![]() |
Bioorg Med Chem 21: 3730-7 (2013) | Korea Research Institute of Bioscience and Biotechnology | 09/01/20 | 2D 3D |
24125888 | 2 | Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors.![]() |
Bioorg Med Chem Lett 23: 6317-20 (2013) | Kansas State University | 09/01/20 | 2D 3D |
23202846 | 4 | Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases.![]() |
Eur J Med Chem 59: 1-6 (2013) | The Chinese University of Hong Kong | 08/31/20 | 2D 3D |
20934345 | 20 | Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition.![]() |
Bioorg Med Chem 18: 7940-7 (2010) | Korea Research Institute of Bioscience and Biotechnology | 08/28/20 | 2D 3D |
20947359 | 18 | Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors.![]() |
Bioorg Med Chem 18: 7849-54 (2010) | Academia Sinica | 08/28/20 | 2D 3D |
19540764 | 1 | Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death.![]() |
Bioorg Med Chem 17: 5139-45 (2009) | National Human Genome Research Institute | 08/27/20 | 2D 3D |
20167482 | 10 | SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii.![]() |
Bioorg Med Chem Lett 20: 1873-6 (2010) | Korea Research Institute of Bioscience and Biotechnology | 08/27/20 | 2D 3D |
19362479 | 15 | New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.![]() |
Bioorg Med Chem Lett 19: 2722-7 (2009) | Kyoto Pharmaceutical University | 08/27/20 | 2D 3D |
17709464 | 8 | Novel small-molecule inhibitors of transmissible gastroenteritis virus.![]() |
Antimicrob Agents Chemother 51: 3924-31 (2007) | National Health Research Institute | 08/27/20 | 2D 3D |
17855091 | 7 | Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors.![]() |
Bioorg Med Chem Lett 17: 5876-80 (2007) | Purdue University | 08/24/20 | 2D 3D |
29544147 | 36 | Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.![]() |
Eur J Med Chem 150: 334-346 (2018) | Wichita State University | 08/16/20 | 2D 3D |
27240464 | 24 | Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors.![]() |
Bioorg Med Chem 24: 3035-3042 (2016) | Academia Sinica | 09/14/17 | 2D 3D |
23323951 | 10 | Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.![]() |
J Enzyme Inhib Med Chem 29: 59-63 (2014) | Gyeongsang National University | 08/28/17 | 2D 3D |
25746232 | 16 | Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.![]() |
ACS Chem Biol 10: 1456-65 (2015) | University of Illinois at Chicago | 10/15/15 | 2D 3D |
24735644 | 19 | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-ß hydrolysis.![]() |
Eur J Med Chem 79: 184-93 (2014) | University of Lille | 02/07/15 | 2D 3D |
18078750 | 76 | Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.![]() |
Bioorg Med Chem Lett 18: 732-7 (2008) | GlaxoSmithKline | 05/21/13 | 2D 3D |
22884354 | 36 | Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.![]() |
Bioorg Med Chem 20: 5928-35 (2012) | Korea Research Institute of Bioscience and Biotechnology | 05/17/13 | 2D 3D |
19144641 | 8 | Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds.![]() |
J Biol Chem 284: 7646-55 (2009) | National Yang-Ming University | 10/29/12 | 2D 3D |
21741839 | 83 | Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.![]() |
Bioorg Med Chem Lett 21: 4860-4 (2011) | Philipps University Marburg | 03/23/12 | 2D 3D |
21470860 | 9 | Virtual screening identification of novel severe acute respiratory syndrome 3C-like protease inhibitors and in vitro confirmation.![]() |
Bioorg Med Chem Lett 21: 3088-91 (2011) | Chonnam National University | 12/04/11 | 2D 3D |
16638531 | 16 | Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease.![]() |
Chem Biol 13: 261-8 (2006) | Academia Sinica | 07/07/11 | 2D 3D |
19483697 | 23 | Phage-encoded combinatorial chemical libraries based on bicyclic peptides.![]() |
Nat Chem Biol 5: 502-7 (2009) | Laboratory of Molecular Biology, Medical Research Council | 06/10/11 | 2D 3D |
19625187 | 22 | Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.![]() |
Bioorg Med Chem Lett 19: 4538-41 (2009) | Konkuk University | 08/27/10 | 2D 3D |
19233643 | 16 | Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase.![]() |
Bioorg Med Chem Lett 19: 1636-8 (2009) | Konkuk University | 01/11/10 | 2D 3D |
18243695 | 44 | Thiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite.![]() |
Bioorg Med Chem Lett 18: 1681-7 (2008) | GlaxoSmithKline | 11/11/09 | 2D 3D |
17381079 | 8 | Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters.![]() |
J Med Chem 50: 1850-64 (2007) | University of Alberta | 11/10/09 | 2D 3D |
16250632 | 2 | Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.![]() |
J Med Chem 48: 6767-71 (2005) | Purdue University | 11/10/09 | 2D 3D |
16759084 | 12 | Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.![]() |
J Med Chem 49: 3440-3 (2006) | Peking University | 11/10/09 | 2D 3D |
15896959 | 14 | Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors.![]() |
Bioorg Med Chem Lett 15: 3058-62 (2005) | Development Center for Biotechnology | 11/10/09 | 2D 3D |
19645480 | 24 | Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease.![]() |
J Med Chem 52: 5228-40 (2009) | Purdue University | 09/14/09 | 2D 3D |
18343121 | 2 | Structure-based virtual screening against SARS-3CL(pro) to identify novel non-peptidic hits.![]() |
Bioorg Med Chem 16: 4138-49 (2008) | University of Mississippi | 07/08/08 | 2D 3D |
16913704 | 21 | Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease.![]() |
J Med Chem 49: 5154-61 (2006) | National Defense Medical Center | 09/26/06 | 2D 3D |
16759091 | 28 | Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies.![]() |
J Med Chem 49: 3485-95 (2006) | National Tsing Hua University | 09/26/06 | 2D 3D |
15974598 | 9 | Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease.![]() |
J Med Chem 48: 4469-73 (2005) | National Taiwan University | 09/26/06 | 2D 3D |
15994085 | 21 | Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters.![]() |
Bioorg Med Chem 13: 5240-52 (2005) | National Taiwan University | 09/26/06 | 2D 3D |
16884309 | 5 | Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor.![]() |
J Med Chem 49: 4971-80 (2006) | TaiGen Biotechnology Co. | 09/23/06 | 2D 3D |