BDBM50367343 (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid::FOLIC ACID::Folacin::Folvite::Vitamin B9::Vitamin M
SMILES Nc1nc2ncc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)nc2c(=O)[nH]1
InChI Key InChIKey=OVBPIULPVIDEAO-LBPRGKRZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50367343
TargetSolute carrier organic anion transporter family member 1A3(Rattus norvegicus)
Kyoto University Hospital
Curated by ChEMBL
Kyoto University Hospital
Curated by ChEMBL
Affinity DataKi: 1.41E+4nMAssay Description:TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.00E+4nMAssay Description:Inhibitory constant of thymidylate synthase was determined in human AML cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibitory activity against the thymidylate synthase in the Permeabilized L1210 cellsMore data for this Ligand-Target Pair
Affinity DataKd: 4.40E+3nMpH: 7.0Assay Description:Dissociation constant at(Koff) Tyr-31 of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+5nMAssay Description:Compound was evaluated for the alpha-Adrenoceptor pA2 blocking activity in vitro in rabbit thoracic aortaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity against thymidylate synthase in the intact L1210 cellsMore data for this Ligand-Target Pair
Affinity DataKd: 810nMpH: 7.0Assay Description:Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7More data for this Ligand-Target Pair
Affinity DataKd: 4.80E+3nMpH: 7.0 T: 2°CAssay Description:Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7More data for this Ligand-Target Pair