BDBM50367298 Cardene::NICARDIPINE
SMILES COC(=O)C1C(C(C(=O)OCCN(C)Cc2ccccc2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O
InChI Key InChIKey=OEIGWXLWQNTHHG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 29 hits for monomerid = 50367298
Affinity DataKi: 280nMAssay Description:Inhibition of human cytochrome P450 2C9More data for this Ligand-Target Pair
Affinity DataKi: 3.25E+3nMAssay Description:Displacement of [125]AB-MECA binding to human Adenosine A3 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
TargetEquilibrative nucleoside transporter 1(Rattus norvegicus)
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 5.36E+3nMAssay Description:Ability to displace radioligand from Na+ independent Adenosine transporter in ratMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+4nMAssay Description:Binding affinity against rat Adenosine A3 receptor from CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.96E+4nMAssay Description:Displacement of [3H](R)-PIA binding to Adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 6.38E+4nMAssay Description:Displacement of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Compound was tested for the inhibition of beta-lactamaseMore data for this Ligand-Target Pair
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of malate dehydrogenase (MDH)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Mus musculus)
Ferrara University
Curated by ChEMBL
Ferrara University
Curated by ChEMBL
Affinity DataEC50: 500nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
Affinity DataIC50: 4.79E+3nMAssay Description:Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.13E+3nMAssay Description:Inhibition of P-glycoprotein by Hoechst assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.46E+4nMAssay Description:TP_TRANSPORTER: inhibition of Fluo-3-AM efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.17E+4nMAssay Description:TP_TRANSPORTER: inhibition of Tetramethylrosamine efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of JC-1 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >2.58E+4nMAssay Description:TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.75E+4nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 1.66E+4nMAssay Description:Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCECMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against Beta-lactamase from DMSO stock was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against Amp C beta-LactamaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.75E+5nMAssay Description:Compound was tested for the inhibition of ChymotrypsinogenMore data for this Ligand-Target Pair