BDBM50176263 3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol::CHEMBL1400::O-DESMETHYL TRAMADOL::Ultracet::rel-3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol

SMILES CN(C)C[C@H]1CCCC[C@]1(O)c1cccc(O)c1

InChI Key InChIKey=UWJUQVWARXYRCG-HIFRSBDPSA-N

Data  8 KI  6 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50176263   

TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataKi:  8.60nMAssay Description:Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]naloxone from human MOR expressed in CHO-K1 cell membranes after 60 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-DAMGO from rat mu opioid receptor expressed in CHO cells incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataKi:  450nMAssay Description:Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataKi:  2.90E+3nMAssay Description:Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DPDPE from human DOR expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataIC50:  47nMAssay Description:Binding affinity to mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataEC50:  240nMAssay Description:Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NET mediated norepinephrine uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of reuptake of 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataIC50:  47nMAssay Description:Inhibition of mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of reuptake of NorepinephrineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataEC50:  245nMAssay Description:Agonist activity at rat mu opioid receptor expressed in CHO cells incubated for 1 hr by [35S]GTPgammaS binding based liquid scintillation counting me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycycl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SERT mediated 5-hydroxytryptamine uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed