BDBM120423 Roche-Dataset for PDE10A, Compound 477::US8703768, 22

SMILES c1cc(nc(c1Nc2cncnc2)C(=O)Nc3cnccc3C(=O)N4CCCC4)C5CC5

InChI Key InChIKey=UZYSPHDFZZFZPA-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 120423   

LigandPNGBDBM120423(US8703768, 22 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 18.7nMAssay Description:PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
US Patent

LigandPNGBDBM120423(US8703768, 22 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 19nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed