BDBM163943 US9062078, 74::US9475819, 74::US9637496, 74::US9695183, 74

SMILES O=C(N1C2CCC1C(COc1ccccn1)C2)c1nc2ccccc2cc1-n1nccn1

InChI Key InChIKey=AYJHDWGNHNBJBV-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 163943   

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163943(US9475819, 74 | US9062078, 74 | US9695183, 74 | US...)
Affinity DataKi:  359nM ΔG°:  -9.23kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163943(US9475819, 74 | US9062078, 74 | US9695183, 74 | US...)
Affinity DataKi:  359nM ΔG°:  -8.17kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163943(US9475819, 74 | US9062078, 74 | US9695183, 74 | US...)
Affinity DataKi:  359nM ΔG°:  -8.17kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163943(US9475819, 74 | US9062078, 74 | US9695183, 74 | US...)
Affinity DataKi:  359nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163943(US9475819, 74 | US9062078, 74 | US9695183, 74 | US...)
Affinity DataKi:  1.70E+3nM ΔG°:  -8.26kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163943(US9475819, 74 | US9062078, 74 | US9695183, 74 | US...)
Affinity DataKi:  1.70E+3nM ΔG°:  -8.26kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163943(US9475819, 74 | US9062078, 74 | US9695183, 74 | US...)
Affinity DataKi:  1.70E+3nM ΔG°:  -8.26kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163943(US9475819, 74 | US9062078, 74 | US9695183, 74 | US...)
Affinity DataKi:  1.70E+3nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent