BDBM22814 5-bromo-2,3-dihydro-1H-indole-2,3-dione::Isatin-based compound, 34::LOR-NEU-c8f11034-3

SMILES Brc1ccc2NC(=O)C(=O)c2c1

InChI Key InChIKey=MBVCESWADCIXJN-UHFFFAOYSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 22814   

TargetLiver carboxylesterase 1(Rabbit)
St. Jude Research Hospital

LigandPNGBDBM22814(5-bromo-2,3-dihydro-1H-indole-2,3-dione | Isatin-b...)
Affinity DataKi:  1.32E+3nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
St. Jude Research Hospital

LigandPNGBDBM22814(5-bromo-2,3-dihydro-1H-indole-2,3-dione | Isatin-b...)
Affinity DataKi:  1.33E+4nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM22814(5-bromo-2,3-dihydro-1H-indole-2,3-dione | Isatin-b...)
Affinity DataIC50: 3.03E+4nMAssay Description:The assay was performed according to the published procedure. Briefly, compounds were seeded into assay-ready plates (Greiner 384PP, cat# 781280) usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article

TargetLiver carboxylesterase 1(Human)
St. Jude Research Hospital

LigandPNGBDBM22814(5-bromo-2,3-dihydro-1H-indole-2,3-dione | Isatin-b...)
Affinity DataKi:  3.17E+4nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetProtein-glutamine gamma-glutamyltransferase 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM22814(5-bromo-2,3-dihydro-1H-indole-2,3-dione | Isatin-b...)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of human transglutaminase 2 using Cbz-Gln-Gly as a substrate by GDH-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22814(5-bromo-2,3-dihydro-1H-indole-2,3-dione | Isatin-b...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22814(5-bromo-2,3-dihydro-1H-indole-2,3-dione | Isatin-b...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed