BDBM234367 Pralidoxime (3)

SMILES C[n+]1ccccc1\C=N\O

InChI Key InChIKey=JBKPUQTUERUYQE-UHFFFAOYSA-O

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 234367   

TargetAcetylcholinesterase(Human)
Institute For Medical Research and Occupational Health

Curated by ChEMBL
LigandPNGBDBM234367(Pralidoxime (3))
Affinity DataKi:  1.80E+5nMAssay Description:Reversible inhibition of recombinant human recombinant AChE using acetylthiocholine iodide as substrate by Ellman spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute For Medical Research and Occupational Health

Curated by ChEMBL
LigandPNGBDBM234367(Pralidoxime (3))
Affinity DataKi:  3.90E+5nMAssay Description:Reversible inhibition of human plasma BChE using acetylthiocholine iodide as substrate by Ellman spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institute For Medical Research and Occupational Health

Curated by ChEMBL
LigandPNGBDBM234367(Pralidoxime (3))
Affinity DataIC50: 8.78E+5nMpH: 7.4Assay Description:Human erythrocyte AChE or human plasmatic BChE (Prague, Aldrich; commercially purified by affinity chromatography) were suspended into phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institute For Medical Research and Occupational Health

Curated by ChEMBL
LigandPNGBDBM234367(Pralidoxime (3))
Affinity DataIC50: 9.96E+5nMAssay Description:Inhibition of human AChE using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition measured every 5 mins for 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed