BDBM25681 4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzamide::aminothiazole analogue, 25

SMILES CNC(=O)c1ccc(cc1)Nc2ncc(s2)Br

InChI Key InChIKey=IMMYNZJEOGNQTM-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25681   

TargetAurora kinase A(Human)
Novartis

LigandPNGBDBM25681(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Affinity DataIC50: 140nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAromatase(Human)
Novartis

LigandPNGBDBM25681(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Affinity DataIC50: 440nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
LigandPNGBDBM25681(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Affinity DataIC50: 4.27E+3nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed