BDBM26230 2-Aminopyrimidine analog., 25::4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzonitrile::JMC516547 Compound 5

SMILES Nc1nc(cc(n1)-c1ccc(cc1)C#N)N1CCNCC1

InChI Key InChIKey=GXPQVRIHPFBPOG-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 26230   

TargetHistamine H4 receptor(Human)
Abbott Laboratories

LigandPNGBDBM26230(4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzon...)
Affinity DataKi:  42nM ΔG°:  -10.1kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Abbott Laboratories

LigandPNGBDBM26230(4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzon...)
Affinity DataKi:  42nM ΔG°:  -10.1kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Abbott Laboratories

LigandPNGBDBM26230(4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzon...)
Affinity DataKi:  120nM ΔG°:  -9.43kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
Abbott Laboratories

LigandPNGBDBM26230(4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzon...)
Affinity DataKi:  339nM ΔG°:  -8.82kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
Abbott Laboratories

LigandPNGBDBM26230(4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzon...)
Affinity DataKi:  339nM ΔG°:  -8.82kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

LigandPNGBDBM26230(4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzon...)
Affinity DataKi:  933nM ΔG°:  -8.22kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2009
Entry Details Article
PubMed