BDBM263470 (s)-n-(1-(4-methoxyphenyl)ethyl)-2-(7-methyl-4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)acetamide::US10561662, Example 35::US11173161, EX 35::US9556130, test 35

SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2cc(C)ccc2c1=O

InChI Key InChIKey=FNEAIYYXBKHWMI-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 263470   

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263470((s)-n-(1-(4-methoxyphenyl)ethyl)-2-(7-methyl-4-oxo...)
Affinity DataKi:  1.52E+3nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263470((s)-n-(1-(4-methoxyphenyl)ethyl)-2-(7-methyl-4-oxo...)
Affinity DataKi:  1.52E+3nM ΔG°:  -7.37kcal/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263470((s)-n-(1-(4-methoxyphenyl)ethyl)-2-(7-methyl-4-oxo...)
Affinity DataKi:  1.52E+6nMAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent