BDBM26891 8-(diphenylmethyl)-1-phenyl-3-propyl-1,3,8-triazaspiro[4.5]decan-4-one::spiropiperidine analogue, 12

SMILES CCCN1CN(c2ccccc2)C2(CCN(CC2)C(c2ccccc2)c2ccccc2)C1=O

InChI Key InChIKey=NAULSWWRXJIQAH-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 26891   

TargetNociceptin receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26891(8-(diphenylmethyl)-1-phenyl-3-propyl-1,3,8-triazas...)
Affinity DataKi:  34nM ΔG°:  -10.1kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26891(8-(diphenylmethyl)-1-phenyl-3-propyl-1,3,8-triazas...)
Affinity DataKi:  1.34E+3nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26891(8-(diphenylmethyl)-1-phenyl-3-propyl-1,3,8-triazas...)
Affinity DataKi:  1.18E+4nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26891(8-(diphenylmethyl)-1-phenyl-3-propyl-1,3,8-triazas...)
Affinity DataKi:  1.53E+4nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed