BDBM26893 8-(diphenylmethyl)-1-phenyl-3-(propan-2-yl)-1,3,8-triazaspiro[4.5]decan-4-one::spiropiperidine analogue, 14

SMILES CC(C)N1CN(c2ccccc2)C2(CCN(CC2)C(c2ccccc2)c2ccccc2)C1=O

InChI Key InChIKey=XUXIHOIDTQZHEK-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 26893   

TargetNociceptin receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26893(8-(diphenylmethyl)-1-phenyl-3-(propan-2-yl)-1,3,8-...)
Affinity DataKi:  66nM ΔG°:  -9.69kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26893(8-(diphenylmethyl)-1-phenyl-3-(propan-2-yl)-1,3,8-...)
Affinity DataKi:  543nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26893(8-(diphenylmethyl)-1-phenyl-3-(propan-2-yl)-1,3,8-...)
Affinity DataKi:  4.04E+3nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26893(8-(diphenylmethyl)-1-phenyl-3-(propan-2-yl)-1,3,8-...)
Affinity DataKi:  9.11E+3nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed