BDBM4625 Anilinoquinazoline deriv. 8::N-(2,4-difluorophenyl)-6,7-dimethoxyquinazolin-4-amine

SMILES COc1cc2ncnc(Nc3ccc(F)cc3F)c2cc1OC

InChI Key InChIKey=WTKCXIAUFZSYSE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4625   

LigandPNGBDBM4625(N-(2,4-difluorophenyl)-6,7-dimethoxyquinazolin-4-a...)
Affinity DataIC50: 2.90E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4625(N-(2,4-difluorophenyl)-6,7-dimethoxyquinazolin-4-a...)
Affinity DataIC50: 2.20E+4nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4625(N-(2,4-difluorophenyl)-6,7-dimethoxyquinazolin-4-a...)
Affinity DataIC50: 5.80E+4nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed