BDBM4841 1-[2-amino-6-(2-ethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea::PD089828 analog 22

SMILES CCc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C

InChI Key InChIKey=MKHPRZXKLFMFAP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4841   

TargetPlatelet-derived growth factor receptor beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4841(1-[2-amino-6-(2-ethylphenyl)pyrido[2,3-d]pyrimidin...)
Affinity DataIC50: 4.48E+3nMpH: 7.4 T: 2°CAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4841(1-[2-amino-6-(2-ethylphenyl)pyrido[2,3-d]pyrimidin...)
Affinity DataIC50: 4.48E+3nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4841(1-[2-amino-6-(2-ethylphenyl)pyrido[2,3-d]pyrimidin...)
Affinity DataIC50: 1.04E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4841(1-[2-amino-6-(2-ethylphenyl)pyrido[2,3-d]pyrimidin...)
Affinity DataIC50: 1.12E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article