BDBM497147 (S)-6-(((1-(tert-butyl)-1H-1,2,3- triazol-4-yl)(6-fluoropyridin-3- yl)methyl-d)amino)-8-chloro-4- (neopentylamino)quinoline-3- carbonitrile::US11066414, Compound 1

SMILES CC(C)(C)CNc1c(cnc2c(Cl)cc(N[C@@H](C3=CN(NN3)C(C)(C)C)c3ccc(F)nc3)cc12)C#N

InChI Key InChIKey=VELILOBNDIFMEI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 497147   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM497147((S)-6-(((1-(tert-butyl)-1H-1,2,3- triazol-4-yl)(6-...)
Affinity DataIC50: 8nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
US Patent