BDBM50006967 CHEMBL53170::US11999676, Compound 26::[2-(4-Methoxy-phenyl)-1-methyl-ethyl]-(3-phenyl-propyl)-amine

SMILES COc1ccc(CC(C)NCCCc2ccccc2)cc1

InChI Key InChIKey=PSDOCJRHKUVMFW-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50006967   

TargetSigma non-opioid intracellular receptor 1(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006967(CHEMBL53170 | [2-(4-Methoxy-phenyl)-1-methyl-ethyl...)
Affinity DataKi:  9.5nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University Of Kentucky Research Foundation

US Patent
LigandPNGBDBM50006967(CHEMBL53170 | [2-(4-Methoxy-phenyl)-1-methyl-ethyl...)
Affinity DataKi:  22nMAssay Description:Inhibition of [3H]DA uptake was conducted using isolated synaptic vesicle preparations (Teng et al., 1997). Briefly, rat striata were homogenized wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2024
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Rat)
University Of Kentucky Research Foundation

US Patent
LigandPNGBDBM50006967(CHEMBL53170 | [2-(4-Methoxy-phenyl)-1-methyl-ethyl...)
Affinity DataKi:  1.27E+3nMAssay Description:Synaptic vesicles were prepared from rat brain using a modification of a previously described procedure (Teng et al., 1998). Briefly, fresh whole bra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2024
Entry Details
US Patent

TargetD(2) dopamine receptor(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006967(CHEMBL53170 | [2-(4-Methoxy-phenyl)-1-methyl-ethyl...)
Affinity DataIC50: 9.32E+3nMAssay Description:In vitro binding affinity at Dopamine receptor D2 in rat striata using [3H]domperidone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006967(CHEMBL53170 | [2-(4-Methoxy-phenyl)-1-methyl-ethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro binding affinity at Dopamine receptor D1 using [3H]SCH-23390 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006967(CHEMBL53170 | [2-(4-Methoxy-phenyl)-1-methyl-ethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro binding affinity at PCP binding site of sigma-opioid receptors using (+)-[3H]-MK-801 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed