BDBM50007694 8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-2,7,9-trione (HCl)::CHEMBL115367

SMILES O=C1CCC2(C1)CC(=O)N(CCCCN1CCN(CC1)c1nsc3ccccc13)C(=O)C2

InChI Key InChIKey=VJBRVSZHSPYQNJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50007694   

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007694(CHEMBL115367 | 8-[4-(4-Benzo[d]isothiazol-3-yl-pip...)
Affinity DataIC50: 1.30nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in rat cerebral cortex tissue using [3H]WB-4101 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007694(CHEMBL115367 | 8-[4-(4-Benzo[d]isothiazol-3-yl-pip...)
Affinity DataIC50: 2.90nMAssay Description:Binding affinity against rat 5-hydroxytryptamine 2 receptor in rat cerebral cortex tissue using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007694(CHEMBL115367 | 8-[4-(4-Benzo[d]isothiazol-3-yl-pip...)
Affinity DataIC50: 3nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue with [3H]5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007694(CHEMBL115367 | 8-[4-(4-Benzo[d]isothiazol-3-yl-pip...)
Affinity DataIC50: 68nMAssay Description:Binding affinity against Dopamine receptor D2 receptor of rat corpus striatal tissue with [3H]spiperoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed