BDBM50048174 CHEMBL3310486

SMILES Fc1ccc(OC(CC2CNC2)c2ccc(Cl)c(F)c2)cc1

InChI Key InChIKey=GVURCJXFYIMVMG-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50048174   

TargetSodium-dependent noradrenaline transporter(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50048174(CHEMBL3310486)
Affinity DataIC50: 33nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50048174(CHEMBL3310486)
Affinity DataIC50: 58nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50048174(CHEMBL3310486)
Affinity DataIC50: 143nMAssay Description:Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50048174(CHEMBL3310486)
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant human CYP3A4 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50048174(CHEMBL3310486)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human CYP2D6 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50048174(CHEMBL3310486)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human CYP2C19 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50048174(CHEMBL3310486)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant human CYP2C9 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50048174(CHEMBL3310486)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of recombinant human CYP1A2 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed