BDBM50084716 (4-Hydroxy-1-methyl-4-p-tolyl-piperidin-3-yl)-p-tolyl-methanone; compound with 8-methyl-8-aza-bicyclo[3.2.1]octane-2,3-dicarboxylic acid 2-methyl ester 3-phenyl ester::CHEMBL120633::CHEMBL331787

SMILES CN1CCC(O)(C(C1)C(=O)c1ccc(C)cc1)c1ccc(C)cc1

InChI Key InChIKey=SWFNNRQTSSTAGB-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50084716   

TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716(CHEMBL120633 | CHEMBL331787 | (4-Hydroxy-1-methyl-...)
Affinity DataKi:  360nMAssay Description:Inhibition of [3H]DA Uptake at Dopamine transporter in rat cortex was measured by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716(CHEMBL120633 | CHEMBL331787 | (4-Hydroxy-1-methyl-...)
Affinity DataIC50: 470nMAssay Description:Antagonism of cocaine''s inhibition of [3H]DA uptake at the dose of 50 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716(CHEMBL120633 | CHEMBL331787 | (4-Hydroxy-1-methyl-...)
Affinity DataKi:  492nMAssay Description:Binding Affinity to cocaine site of Dopamine transporter in caudate nuclei which was homogenized and incubated with [3H]mazindol. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716(CHEMBL120633 | CHEMBL331787 | (4-Hydroxy-1-methyl-...)
Affinity DataIC50: 717nMAssay Description:Antagonism of cocaine''s inhibition of [3H]DA uptake at the dose of 200 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716(CHEMBL120633 | CHEMBL331787 | (4-Hydroxy-1-methyl-...)
Affinity DataIC50: 1.16E+3nMAssay Description:Antagonism of cocaine''s inhibition of [3H]DA uptake at the dose of 500 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716(CHEMBL120633 | CHEMBL331787 | (4-Hydroxy-1-methyl-...)
Affinity DataKi:  1.63E+3nMAssay Description:Compound was tested for Inhibition of [3H]5-HT Uptake in rat mid brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716(CHEMBL120633 | CHEMBL331787 | (4-Hydroxy-1-methyl-...)
Affinity DataKi:  3.86E+3nMAssay Description:Compound was tested for Inhibition of [3H]NE Uptake in rat parietal/occipital cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed