BDBM50095239 6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-3-carbonitrile::CHEMBL30763

SMILES COc1cc2ncc(C#N)c(Nc3cccc(Oc4ccccc4)c3)c2cc1OC

InChI Key InChIKey=VVHLRJCWFVPVSW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50095239   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095239(6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50: 60nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50095239(6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50: 95nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095239(6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50095239(6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50: 160nMAssay Description:Inhibition of Dual specificity mitogen-activated protein kinase kinase in coupled activated Raf/MEK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed