BDBM50112718 2-Benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(5-methyl-thiophen-2-yl)-2H-chromene-3-carboxylic acid::CHEMBL293012

SMILES CC(C)Oc1ccc2OC(C(C(O)=O)=C(c3ccc(C)s3)c2c1)c1ccc2OCOc2c1

InChI Key InChIKey=FSKVJGRQYIHVTI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50112718   

TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112718(2-Benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(5-methyl-t...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112718(2-Benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(5-methyl-t...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50112718(2-Benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(5-methyl-t...)
Affinity DataIC50: 1nMAssay Description:Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112718(2-Benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(5-methyl-t...)
Affinity DataIC50: 1.80E+3nMAssay Description:Displacement of [125I]-ET-1 from human ETB receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112718(2-Benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(5-methyl-t...)
Affinity DataIC50: 1.80E+3nMAssay Description:Displacement of [125I]-ET-1 from human ETB receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50112718(2-Benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(5-methyl-t...)
Affinity DataIC50: 1.80E+3nMAssay Description:Binding affinity to endothelin B receptor measured by inhibition of [125I]ET-3 binding recombinant pig ET-B receptor expressed in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed