BDBM50122807 1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one::CHEMBL328187

SMILES Cn1cc(nn1)-c1ccc2n(cc(C3CCN(CCN4CCNC4=O)CC3)c2c1)-c1ccc(F)cc1

InChI Key InChIKey=DUTDDZFCPPOWFH-UHFFFAOYSA-N

Data  15 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50122807   

TargetAlpha-1A adrenergic receptor(Bovine)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]prozosin from bovine cloned Alpha-1A receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Bovine)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]prazosine from bovine alpha1A adrenoceptor expressed in BHK cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Golden hamster)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]prazosine from hamster alpha1B adrenoceptor expressed in Rat1 cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Golden hamster)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]prozosin from hamster cloned alpha-1b receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H]prozosin from rat cloned alpha1d receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  29nMAssay Description:Ability to displace [3H]5-CT (2.0 nM) from HeLa cells of human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  36nMAssay Description:Ability to displace [3H]5-CT (1.5 nM) from HeLa cells of human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]ketanserin (0.5 nM) from rat cerebral cortex 5-hydroxytryptamine 2A receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]prozosin from human cloned 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  310nMAssay Description:Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  310nMAssay Description:Displacement of [3H]spiperone (0.5 nM) from rat corpus striatum dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  310nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]mesulergine (0.5 nM) from rat 5-hydroxytryptamine 2C receptor expressed in SR-3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122807(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed