BDBM50136594 3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-N-methyl-benzamide::CHEMBL136421

SMILES CNC(=O)c1cccc(c1)[C@]1(C)CCN(CCc2ccccc2)C[C@@H]1C

InChI Key InChIKey=ZKUFOUJYDOLPRR-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50136594   

TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50136594(3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl...)
Affinity DataIC50: 24nMAssay Description:Concentration required to inhibit agonist (loperamide) stimulated [35S]GTP-gamma-S, binding to membranes containing the cloned human mu opioid recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50136594(3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl...)
Affinity DataKi:  71nMAssay Description:Inhibition of binding of the non-selective opioid antagonist, [3H]diprenorphine, to cloned human mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50136594(3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of [3H]diprenorphine binding to the cloned human delta opioid receptors using 10 uM concentration of the compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50136594(3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl...)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity at cloned human kappa opioid receptor by [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed