BDBM50143736 (2,6-Dimethyl-phenyl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone::(2,6-dimethylphenyl)(4-(4-(diphenylamino)piperidin-1-yl)-4-methylpiperidin-1-yl)methanone::CHEMBL62152

SMILES Cc1cccc(C)c1C(=O)N1CCC(C)(CC1)N1CCC(CC1)N(c1ccccc1)c1ccccc1

InChI Key InChIKey=NCDCQNWXYJMYAZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50143736   

TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143736((2,6-dimethylphenyl)(4-(4-(diphenylamino)piperidin...)
Affinity DataIC50: 0.700nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Crab-eating macaque)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143736((2,6-dimethylphenyl)(4-(4-(diphenylamino)piperidin...)
Affinity DataIC50: 0.700nMAssay Description:Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143736((2,6-dimethylphenyl)(4-(4-(diphenylamino)piperidin...)
Affinity DataIC50: 2.60nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143736((2,6-dimethylphenyl)(4-(4-(diphenylamino)piperidin...)
Affinity DataIC50: 2.60nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143736((2,6-dimethylphenyl)(4-(4-(diphenylamino)piperidin...)
Affinity DataIC50: 14.4nMAssay Description:Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143736((2,6-dimethylphenyl)(4-(4-(diphenylamino)piperidin...)
Affinity DataIC50: 15.3nMAssay Description:Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143736((2,6-dimethylphenyl)(4-(4-(diphenylamino)piperidin...)
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed