BDBM50151623 8''-chloro-6''-(4-pyridyl)spiro[cyclohexane-1,4''-(1'',2'',3'',4''-tetrahydroquinazoline)]-2''-one::CHEMBL185208

SMILES Clc1cc(cc2c1NC(=O)NC21CCCCC1)-c1ccncc1

InChI Key InChIKey=FMESWXOJQKIMDP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50151623   

LigandPNGBDBM50151623(8''-chloro-6''-(4-pyridyl)spiro[cyclohexane-1,4''-...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151623(8''-chloro-6''-(4-pyridyl)spiro[cyclohexane-1,4''-...)
Affinity DataIC50: 1.01E+3nMAssay Description:In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151623(8''-chloro-6''-(4-pyridyl)spiro[cyclohexane-1,4''-...)
Affinity DataIC50: 3.01E+3nMAssay Description:In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151623(8''-chloro-6''-(4-pyridyl)spiro[cyclohexane-1,4''-...)
Affinity DataIC50: 9.47E+3nMAssay Description:In vitro inhibition of human Phosphodiesterase 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151623(8''-chloro-6''-(4-pyridyl)spiro[cyclohexane-1,4''-...)
Affinity DataIC50: 1.12E+4nMAssay Description:In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed