BDBM50154852 CHEMBL3775737::US10273244, Example 41::US10584135, Example 41

SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1C1CCOCC1

InChI Key InChIKey=AJEQJTPMMJPNLR-UHFFFAOYSA-N

Data  8 KI  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50154852   

TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL

LigandBDBM50154852(CHEMBL3775737 | US10273244, Example 41 | US1058413...)Copy SMILESCopy InChI

Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/8/2017
Entry Details Article
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TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL

LigandBDBM50154852(CHEMBL3775737 | US10273244, Example 41 | US1058413...)Copy SMILESCopy InChI

Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/8/2017
Entry Details Article
Copy BDB DOIPubMed
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TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL

LigandBDBM50154852(CHEMBL3775737 | US10273244, Example 41 | US1058413...)Copy SMILESCopy InChI

Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/8/2017
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL

LigandBDBM50154852(CHEMBL3775737 | US10273244, Example 41 | US1058413...)Copy SMILESCopy InChI

Affinity DataKi:  2.75nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/29/2020
Entry Details
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TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL

LigandBDBM50154852(CHEMBL3775737 | US10273244, Example 41 | US1058413...)Copy SMILESCopy InChI

Affinity DataKi:  2.75nMAssay Description:3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2020
Entry Details
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TargetD(2) dopamine receptor(Human)
Aptuit

Curated by ChEMBL

LigandBDBM50154852(CHEMBL3775737 | US10273244, Example 41 | US1058413...)Copy SMILESCopy InChI

Affinity DataKi:  251nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/8/2017
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetD(2) dopamine receptor(Human)
Aptuit

Curated by ChEMBL

LigandBDBM50154852(CHEMBL3775737 | US10273244, Example 41 | US1058413...)Copy SMILESCopy InChI

Affinity DataKi:  251nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/8/2017
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetD(2) dopamine receptor(Human)
Aptuit

Curated by ChEMBL

LigandBDBM50154852(CHEMBL3775737 | US10273244, Example 41 | US1058413...)Copy SMILESCopy InChI

Affinity DataKi:  251nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/8/2017
Entry Details Article
Copy BDB DOIPubMed
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aptuit

Curated by ChEMBL

LigandBDBM50154852(CHEMBL3775737 | US10273244, Example 41 | US1058413...)Copy SMILESCopy InChI

Affinity DataIC50: 794nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/8/2017
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aptuit

Curated by ChEMBL

LigandBDBM50154852(CHEMBL3775737 | US10273244, Example 41 | US1058413...)Copy SMILESCopy InChI

Affinity DataIC50: 794nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/8/2017
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL